ES8105736A1 - Un procedimiento para la preparacion de compuestos de tia- diazolo- y oxadiazolo-tetrahidroisoquinolina - Google Patents
Un procedimiento para la preparacion de compuestos de tia- diazolo- y oxadiazolo-tetrahidroisoquinolinaInfo
- Publication number
- ES8105736A1 ES8105736A1 ES492971A ES492971A ES8105736A1 ES 8105736 A1 ES8105736 A1 ES 8105736A1 ES 492971 A ES492971 A ES 492971A ES 492971 A ES492971 A ES 492971A ES 8105736 A1 ES8105736 A1 ES 8105736A1
- Authority
- ES
- Spain
- Prior art keywords
- preparing
- compositions containing
- tetrahydroisoquinoline derivatives
- tetrahydroisoquinoline
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE TIADIAZOLO Y OXADIAZOLOTETRAHIDROISOQUINOLINA DE FORMULA (I), DONDE X ES AZUFRE U OXIGENO Y SUS ISOMEROS. EL PROCESO CONSISTE, CUANDO X ES AZUFRE, EN CICLIZAR -2-ACETIL-8(7)-AMINO-7(8)-R-TIO-1,2,3,4-TETRAHIDROISOQUINOLINA POR DIAZOTACION E HIDROLISIS. CUANDO X ES OXIGENO CONSISTE EN CICLIZAR 2-ACETIL-8(7)-AMINO-7(8)-OXI-1,2,3,4-TETRAHIDROISOQUINOLINA, DIAZOTAR Y NEUTRALIZAR. ESTOS COMPUESTOS ACTUAN COMO INHIBIDORES FARMACEUTICOS DE LA ENCIMA N-METIL-TRANSFERASA DE FENILETANOLAMINA. *FORMULA*
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5434379A | 1979-07-02 | 1979-07-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8105736A1 true ES8105736A1 (es) | 1981-06-01 |
| ES492971A0 ES492971A0 (es) | 1981-06-01 |
Family
ID=21990408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES492971A Granted ES492971A0 (es) | 1979-07-02 | 1980-07-01 | Un procedimiento para la preparacion de compuestos de tia- diazolo- y oxadiazolo-tetrahidroisoquinolina |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP0023761B1 (es) |
| JP (1) | JPS5610192A (es) |
| KR (1) | KR840000396B1 (es) |
| AR (1) | AR225925A1 (es) |
| AT (1) | ATE6515T1 (es) |
| AU (1) | AU531641B2 (es) |
| BG (1) | BG51250A3 (es) |
| CA (1) | CA1129415A (es) |
| CS (1) | CS215064B2 (es) |
| DD (1) | DD151750A5 (es) |
| DE (1) | DE3066826D1 (es) |
| DK (1) | DK151029C (es) |
| ES (1) | ES492971A0 (es) |
| FI (1) | FI67221C (es) |
| GR (1) | GR69206B (es) |
| HU (1) | HU179382B (es) |
| IE (1) | IE50290B1 (es) |
| IL (1) | IL60426A (es) |
| IN (1) | IN160542B (es) |
| MX (1) | MX6317E (es) |
| NO (1) | NO801951L (es) |
| NZ (1) | NZ194156A (es) |
| PH (1) | PH17042A (es) |
| PL (2) | PL127098B1 (es) |
| PT (1) | PT71458A (es) |
| RO (1) | RO79707A (es) |
| SU (1) | SU1072809A3 (es) |
| YU (1) | YU171180A (es) |
| ZA (1) | ZA802987B (es) |
| ZW (1) | ZW14680A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4352809A (en) * | 1981-09-04 | 1982-10-05 | Smithkline Corporation | Method of producing alpha2 antagonism |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3988339A (en) * | 1974-02-08 | 1976-10-26 | Smithkline Corporation | Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase |
| US3939164A (en) * | 1974-02-08 | 1976-02-17 | Smithkline Corporation | 7 AND 8-Halo substituted 1,2,3,4-tetrahydroisoquinoline compounds |
-
1980
- 1980-05-20 ZA ZA00802987A patent/ZA802987B/xx unknown
- 1980-06-25 CA CA354,710A patent/CA1129415A/en not_active Expired
- 1980-06-25 CS CS804525A patent/CS215064B2/cs unknown
- 1980-06-25 PH PH24191A patent/PH17042A/en unknown
- 1980-06-25 JP JP8720980A patent/JPS5610192A/ja active Pending
- 1980-06-26 IN IN485/DEL/80A patent/IN160542B/en unknown
- 1980-06-26 AU AU59677/80A patent/AU531641B2/en not_active Ceased
- 1980-06-26 EP EP80302140A patent/EP0023761B1/en not_active Expired
- 1980-06-26 PT PT71458A patent/PT71458A/pt unknown
- 1980-06-26 NZ NZ194156A patent/NZ194156A/xx unknown
- 1980-06-26 DE DE8080302140T patent/DE3066826D1/de not_active Expired
- 1980-06-26 AT AT80302140T patent/ATE6515T1/de not_active IP Right Cessation
- 1980-06-26 DK DK274280A patent/DK151029C/da not_active IP Right Cessation
- 1980-06-27 IL IL60426A patent/IL60426A/xx unknown
- 1980-06-27 NO NO801951A patent/NO801951L/no unknown
- 1980-06-27 ZW ZW146/80A patent/ZW14680A1/xx unknown
- 1980-06-28 KR KR1019800002551A patent/KR840000396B1/ko active
- 1980-06-30 DD DD80222268A patent/DD151750A5/de unknown
- 1980-06-30 IE IE1352/80A patent/IE50290B1/en unknown
- 1980-06-30 AR AR281587A patent/AR225925A1/es active
- 1980-06-30 RO RO80101552A patent/RO79707A/ro unknown
- 1980-07-01 BG BG048339A patent/BG51250A3/xx unknown
- 1980-07-01 PL PL1980225377A patent/PL127098B1/pl unknown
- 1980-07-01 FI FI802112A patent/FI67221C/fi not_active IP Right Cessation
- 1980-07-01 ES ES492971A patent/ES492971A0/es active Granted
- 1980-07-01 HU HU80801631A patent/HU179382B/hu unknown
- 1980-07-01 SU SU802942953A patent/SU1072809A3/ru active
- 1980-07-01 PL PL23061980A patent/PL230619A1/xx unknown
- 1980-07-01 GR GR62330A patent/GR69206B/el unknown
- 1980-07-01 YU YU01711/80A patent/YU171180A/xx unknown
- 1980-07-02 MX MX808900U patent/MX6317E/es unknown
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