ES8104301A1 - Mejoras introducidas en un procedimiento para la produccion de una penicilina - Google Patents
Mejoras introducidas en un procedimiento para la produccion de una penicilinaInfo
- Publication number
- ES8104301A1 ES8104301A1 ES490644A ES490644A ES8104301A1 ES 8104301 A1 ES8104301 A1 ES 8104301A1 ES 490644 A ES490644 A ES 490644A ES 490644 A ES490644 A ES 490644A ES 8104301 A1 ES8104301 A1 ES 8104301A1
- Authority
- ES
- Spain
- Prior art keywords
- penicillins
- production
- acid chloride
- anhydrous
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 2
- 150000002960 penicillins Chemical class 0.000 title abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
- 229960003022 amoxicillin Drugs 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 229960000723 ampicillin Drugs 0.000 abstract 1
- 230000005587 bubbling Effects 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- -1 e.g. Natural products 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO DE PRODUCCION DE UNA PENICILINA DE FORMULA (I), DONDE *FORMULA* ES EL RESTO QUE QUEDA DESPUES DE SEPARAR EL GRUPO HIDROXILO DE UN ACIDO CARBOXILICO ORGANICO. EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR EL CLORURO DE ACIDO DEL ACIDO CARBOXILICO ORGANICO CON UN NUCLEO SILILADO DE FORMULA (II), DONDE B ES UN GRUPO ESTER PROTECTOR. EL NUCLEO SILILADO SE CONVIERTE EN UN COMPUESTO DE FORMULA (III), CON DIOXIDO DE CARBONO SECO EN UN DISOLVENTE ORGANICO INERTE ANHIDRO, A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 100GC, HASTA REACCION COMPLETA. ESTE COMPUESTO SE EMPLEA COMO AGENTE ANTIBACTERIANO. *FORMULA* R
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97070478A | 1978-12-18 | 1978-12-18 | |
| US478079A | 1979-01-19 | 1979-01-19 | |
| US06/021,852 US4240960A (en) | 1979-03-19 | 1979-03-19 | Trimethylsilyl substituted penicillins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES490644A0 ES490644A0 (es) | 1981-04-01 |
| ES8104301A1 true ES8104301A1 (es) | 1981-04-01 |
Family
ID=27357705
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES482986A Expired ES482986A1 (es) | 1978-12-18 | 1979-07-30 | Un procedimiento para la produccion de derivados sililados- de penicilina. |
| ES490644A Expired ES8104301A1 (es) | 1978-12-18 | 1980-04-16 | Mejoras introducidas en un procedimiento para la produccion de una penicilina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES482986A Expired ES482986A1 (es) | 1978-12-18 | 1979-07-30 | Un procedimiento para la produccion de derivados sililados- de penicilina. |
Country Status (20)
| Country | Link |
|---|---|
| AR (1) | AR225898A1 (es) |
| AT (1) | AT364849B (es) |
| AU (1) | AU531779B2 (es) |
| CA (1) | CA1141752A (es) |
| CH (1) | CH642972A5 (es) |
| DK (2) | DK160613C (es) |
| ES (2) | ES482986A1 (es) |
| FI (1) | FI69846C (es) |
| FR (1) | FR2444683A1 (es) |
| GB (1) | GB2037275B (es) |
| GR (1) | GR73899B (es) |
| IE (1) | IE48521B1 (es) |
| IL (1) | IL57909A (es) |
| IT (1) | IT1117760B (es) |
| LU (1) | LU81432A1 (es) |
| NL (1) | NL171271C (es) |
| NO (1) | NO158541C (es) |
| PH (1) | PH16327A (es) |
| SE (2) | SE436281B (es) |
| YU (1) | YU221082A (es) |
-
1979
- 1979-05-22 SE SE7904483A patent/SE436281B/sv not_active IP Right Cessation
- 1979-05-23 DK DK213779A patent/DK160613C/da not_active IP Right Cessation
- 1979-05-29 CA CA000328553A patent/CA1141752A/en not_active Expired
- 1979-05-29 GR GR59209A patent/GR73899B/el unknown
- 1979-05-30 FI FI791732A patent/FI69846C/fi not_active IP Right Cessation
- 1979-05-31 NO NO791823A patent/NO158541C/no unknown
- 1979-06-01 GB GB7919231A patent/GB2037275B/en not_active Expired
- 1979-06-05 AU AU47774/79A patent/AU531779B2/en not_active Ceased
- 1979-06-12 FR FR7915037A patent/FR2444683A1/fr active Granted
- 1979-06-13 AT AT0421579A patent/AT364849B/de not_active IP Right Cessation
- 1979-06-13 CH CH554179A patent/CH642972A5/de not_active IP Right Cessation
- 1979-06-19 NL NLAANVRAGE7904805,A patent/NL171271C/xx not_active IP Right Cessation
- 1979-06-27 LU LU81432A patent/LU81432A1/fr unknown
- 1979-07-16 PH PH22784A patent/PH16327A/en unknown
- 1979-07-26 AR AR277486A patent/AR225898A1/es active
- 1979-07-27 IL IL57909A patent/IL57909A/xx not_active IP Right Cessation
- 1979-07-30 ES ES482986A patent/ES482986A1/es not_active Expired
- 1979-08-01 IT IT49919/79A patent/IT1117760B/it active
- 1979-08-08 IE IE1283/79A patent/IE48521B1/en not_active IP Right Cessation
-
1980
- 1980-04-16 ES ES490644A patent/ES8104301A1/es not_active Expired
-
1982
- 1982-10-01 YU YU02210/82A patent/YU221082A/xx unknown
-
1984
- 1984-03-02 SE SE8401182A patent/SE448630B/sv not_active IP Right Cessation
-
1990
- 1990-06-13 DK DK143990A patent/DK162055C/da not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |