ES8201585A2 - Mejoras introducidas en un procedimiento para la produccion de una penicilina. - Google Patents

Mejoras introducidas en un procedimiento para la produccion de una penicilina.

Info

Publication number
ES8201585A2
ES8201585A2 ES493608A ES49360880A ES8201585A2 ES 8201585 A2 ES8201585 A2 ES 8201585A2 ES 493608 A ES493608 A ES 493608A ES 49360880 A ES49360880 A ES 49360880A ES 8201585 A2 ES8201585 A2 ES 8201585A2
Authority
ES
Spain
Prior art keywords
penicillins
production
acid chloride
acid
trimethylsilyloxycarbonylaminopenicillanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493608A
Other languages
English (en)
Other versions
ES493608A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES493608A0 publication Critical patent/ES493608A0/es
Publication of ES8201585A2 publication Critical patent/ES8201585A2/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

MODIFICACIONES INTRODUCIDAS EN UN PROCEDIMIENTO PARA LA PRODUCCION DE PENICILINA (CERTIFICADO DE ADICION A LA PATENTE PRINCIPAL NUMERO 490644). LAS MODIFICACIONES CONSISTEN EN LA ADICION DESPUES DE LA SILILACION Y ANTES DE LA CARBONATACION DE UNA CANTIDAD DE UREA QUE ES EXACTAMENTE SUFICIENTE PARA CONVERTIR EN SU HIDROCARBURO A LA TOTALIDAD DE LA BASE ORGANICA LIBRE QUE QUEDA DESPUES DE LA SILILACION. SE AÑADE UNA CANTIDAD DE UREA EQUIVALENTE AL EXCESO ESTEQUIOMETRICO SOBRE UN COMPUESTO (I) DE DICHA BASE ORGANICA FUERTE EN LA MEZCLA DE REACCION DESPUES DE LA SILILACION.
ES493608A 1979-07-20 1980-07-21 Mejoras introducidas en un procedimiento para la produccion de una penicilina. Expired ES8201585A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/059,401 US4278600A (en) 1979-03-19 1979-07-20 Production of penicillins

Publications (2)

Publication Number Publication Date
ES493608A0 ES493608A0 (es) 1981-12-16
ES8201585A2 true ES8201585A2 (es) 1981-12-16

Family

ID=22022709

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493608A Expired ES8201585A2 (es) 1979-07-20 1980-07-21 Mejoras introducidas en un procedimiento para la produccion de una penicilina.

Country Status (13)

Country Link
US (1) US4278600A (es)
JP (1) JPS5625189A (es)
AR (1) AR226858A1 (es)
AT (1) AT368160B (es)
CA (1) CA1141753A (es)
CH (1) CH647522A5 (es)
DK (1) DK148324C (es)
ES (1) ES8201585A2 (es)
IT (1) IT1188986B (es)
NL (1) NL8004171A (es)
NO (1) NO160371C (es)
SE (1) SE450119B (es)
YU (1) YU42978B (es)

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
US3008956A (en) * 1959-08-03 1961-11-14 Beecham Res Lab Process for the recovery of 6-aminopenicillanic acid
DE1159449B (de) * 1961-03-22 1963-12-19 Gruenenthal Chemie Verfahren zur Herstellung von 6-Acylaminopenicillansaeuren und deren Salzen
SE302125B (es) 1961-03-23 1968-07-08 Bristol Myers Co
DE1420981C3 (de) 1961-03-23 1976-01-02 Chemie Gruenenthal Gmbh, 5190 Stolberg Verfahren zur Herstellung von 6-Acylaminopenicillansäuren
ES284254A1 (es) 1962-01-29 1963-07-16 Bristol Myers Co Un procedimiento para la producción de una alfa-aminobencilopenilina
GB959853A (en) 1962-02-28 1964-06-03 Beecham Res Lab Penicillins
US3180862A (en) * 1962-10-29 1965-04-27 Bristol Myers Co Aryl sulfonic acid salts of alpha-aminobenzylpenicillins
DE1249280B (de) * 1962-11-02 1967-09-07 Beecham GrouD Limited, Brentford Middlesex (Großbritannien) Verfahren zur Herstellung von Hydroxybenzyl y amino-pemciUmen
US3198804A (en) * 1963-01-25 1965-08-03 Bristol Myers Co alpha-aminomethylpenicillin derivatives
US3271389A (en) * 1963-03-21 1966-09-06 Bristol Myers Co Process for the isolation of certain basic penicillins
US3499909A (en) * 1966-05-18 1970-03-10 Koninklijke Gist Spiritus Process for production of 6-aminopenicillanic acid
US3487073A (en) * 1967-09-15 1969-12-30 American Home Prod Process for the preparation of anhydrous ampicillin
US3479338A (en) * 1967-10-02 1969-11-18 American Home Prod Process for the preparation of anhydrous ampicillin using silylated ampicillin acid salt
US3478018A (en) * 1967-10-02 1969-11-11 American Home Prod Process for producing alpha-amino penicillins
US3654266A (en) * 1968-05-08 1972-04-04 American Home Prod Intermediates for preparing semisynthetic penicillins and methods of production
GB1241844A (en) * 1968-08-23 1971-08-04 Beecham Group Ltd Penicillins
US3595855A (en) * 1968-12-05 1971-07-27 American Home Prod Process for producing aminopenicillins
ES401263A1 (es) 1972-03-28 1975-02-16 Beecham Group Ltd Un procedimiento para la produccion de alfa - amino-(p-hi- droxibencil) penicilina.
US3912719A (en) * 1974-01-28 1975-10-14 Bristol Myers Co Production of semisynthetic penicillins
US3980637A (en) * 1975-03-17 1976-09-14 Bristol-Myers Company Production of amoxicillin
GB1459807A (en) 1975-05-27 1976-12-31 Proter Spa Process for the production of 7-d-a-amino-phenyl-acetamido-3- desacetoxy-cephalosporanic acid
US4181656A (en) * 1976-01-15 1980-01-01 Glaxo Group Limited Manufacture of semi-synthetic penicillin antibiotics
GB2001985B (en) 1977-08-05 1982-07-07 Lark Spa Process for the preparation of penicillanic and cephalosporanic acid derivatives
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.

Also Published As

Publication number Publication date
ATA376680A (de) 1982-01-15
DK312580A (da) 1981-01-21
NO160371B (no) 1989-01-02
JPS637190B2 (es) 1988-02-15
DK148324C (da) 1985-11-11
DK148324B (da) 1985-06-10
IT8049290A1 (it) 1982-01-21
YU184080A (en) 1983-02-28
AT368160B (de) 1982-09-27
JPS5625189A (en) 1981-03-10
ES493608A0 (es) 1981-12-16
US4278600A (en) 1981-07-14
AR226858A1 (es) 1982-08-31
CH647522A5 (en) 1985-01-31
NO802145L (no) 1981-01-21
NO160371C (no) 1989-04-12
CA1141753A (en) 1983-02-22
NL8004171A (nl) 1981-01-22
IT8049290A0 (it) 1980-07-21
IT1188986B (it) 1988-01-28
SE450119B (sv) 1987-06-09
YU42978B (en) 1989-02-28
SE8005289L (sv) 1981-01-21

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