ES480623A1 - Procedimiento para la preparacion de acidos 2-piridil y 2- pirimidilaminobenzoicos. - Google Patents
Procedimiento para la preparacion de acidos 2-piridil y 2- pirimidilaminobenzoicos.Info
- Publication number
- ES480623A1 ES480623A1 ES480623A ES480623A ES480623A1 ES 480623 A1 ES480623 A1 ES 480623A1 ES 480623 A ES480623 A ES 480623A ES 480623 A ES480623 A ES 480623A ES 480623 A1 ES480623 A1 ES 480623A1
- Authority
- ES
- Spain
- Prior art keywords
- amino
- salts
- pyridyl
- tetrazol
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Procedimiento para la preparación de nuevos ácidos 2-piridil y 2-pirimidilaminobenzóicos de la fórmula **fórmula ** en la que A representa =CH - o =N-;R1, representa a) hidrógeno, alcohilo inferior, alcoxi inferior, un anillo bencénico condensado, o b) -COOH o tetrazol -5-ilo en posición 4 o 5, R2 representa -COOH, tetrazol-5-ilo o, en caso de que R1 tenga uno de los significados indicados en b) , también hidrógeno, alcohilo inferior, alcoxi inferior o un anillo bencénico condensado, siendo -COOH por lo menos uno de los radicales R1 y R2, eventualmente en forma de sales internas o como sales con componentes básicos, caracterizado porque se hidroliza un compuesto de la fórmula **fórmula** en la que A tiene los significados arriba indicados, R''3 representa R3 o un grupo protector amino, R''1 representa R1 o un derivado funcional de grupo carboxilo, y -r''2 representa R2 o un derivado funcional del grupo carboxilo, siendo por lo menos uno de los radicales R''1 y R''2 un derivado funcional del grupo carboxilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772735919 DE2735919A1 (de) | 1977-08-10 | 1977-08-10 | Neue 2-pyridyl- und 2-pyrimidylaminobenzoesaeuren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES480623A1 true ES480623A1 (es) | 1980-01-01 |
Family
ID=6016013
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES472143A Expired ES472143A1 (es) | 1977-08-10 | 1978-07-28 | Procedimiento para la preparacion de acidos 2-piridil- y 2-pirimidilaminobenzoicos. |
| ES475456A Expired ES475456A1 (es) | 1977-08-10 | 1978-11-28 | Procedimiento para la preparacion de acidos 2-piridil- y 2- pirimidilaminobenzoicos. |
| ES475457A Expired ES475457A1 (es) | 1977-08-10 | 1978-11-28 | Procedimiento para la preparacion de nuevos acidos 2-piri- dil- y 2-pirimidilaminobenzoicos |
| ES480623A Expired ES480623A1 (es) | 1977-08-10 | 1979-05-16 | Procedimiento para la preparacion de acidos 2-piridil y 2- pirimidilaminobenzoicos. |
| ES480622A Expired ES480622A1 (es) | 1977-08-10 | 1979-05-16 | Procedimiento para la preparacion de nuevo acidos 2-piridil-y -2-pirimidilaminobenzoicos. |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES472143A Expired ES472143A1 (es) | 1977-08-10 | 1978-07-28 | Procedimiento para la preparacion de acidos 2-piridil- y 2-pirimidilaminobenzoicos. |
| ES475456A Expired ES475456A1 (es) | 1977-08-10 | 1978-11-28 | Procedimiento para la preparacion de acidos 2-piridil- y 2- pirimidilaminobenzoicos. |
| ES475457A Expired ES475457A1 (es) | 1977-08-10 | 1978-11-28 | Procedimiento para la preparacion de nuevos acidos 2-piri- dil- y 2-pirimidilaminobenzoicos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES480622A Expired ES480622A1 (es) | 1977-08-10 | 1979-05-16 | Procedimiento para la preparacion de nuevo acidos 2-piridil-y -2-pirimidilaminobenzoicos. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US4241068A (es) |
| JP (1) | JPS5430177A (es) |
| AT (1) | AT370415B (es) |
| AU (1) | AU520240B2 (es) |
| BE (1) | BE869640A (es) |
| BG (1) | BG30472A1 (es) |
| CA (1) | CA1111037A (es) |
| CH (1) | CH649289A5 (es) |
| CS (1) | CS202506B2 (es) |
| DD (1) | DD140351A5 (es) |
| DE (1) | DE2735919A1 (es) |
| DK (1) | DK148019C (es) |
| ES (5) | ES472143A1 (es) |
| FI (1) | FI71555C (es) |
| FR (1) | FR2400017A1 (es) |
| GB (1) | GB2002764B (es) |
| GR (1) | GR65024B (es) |
| HU (1) | HU179933B (es) |
| IE (1) | IE47228B1 (es) |
| IT (1) | IT1107960B (es) |
| LU (1) | LU80094A1 (es) |
| MX (1) | MX5672E (es) |
| NL (1) | NL7808319A (es) |
| NO (1) | NO152605C (es) |
| NZ (1) | NZ188101A (es) |
| PH (1) | PH19117A (es) |
| PL (2) | PL115778B1 (es) |
| PT (1) | PT68407A (es) |
| SE (1) | SE444170B (es) |
| SU (2) | SU735168A3 (es) |
| YU (1) | YU40832B (es) |
| ZA (1) | ZA784501B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3100516A1 (de) * | 1981-01-10 | 1982-08-12 | C.H. Boehringer Sohn, 6507 Ingelheim | Pyridylaminobenzoesaeuren, ihre herstellung und verwendung |
| FR2533567A1 (fr) * | 1982-09-23 | 1984-03-30 | Ki I Farmakologii | 2-(orthocarboxyphenylamino)-6h-pyrimido (2,1-b)-quinazolone-6 et ses derives, leur procede de preparation et leur application therapeutique |
| US4610991A (en) * | 1983-04-18 | 1986-09-09 | Sterling Drug Inc. | Antihypertensive pyridylaminobenzamide compounds |
| JPS60100559A (ja) * | 1983-11-05 | 1985-06-04 | Morishita Seiyaku Kk | ２−アニリノ−１，６−ジヒドロ−６−オキソ−５−ピリミジンカルボン酸誘導体，その製法及び該化合物を含有する抗アレルギ−剤 |
| US4584379A (en) * | 1985-01-22 | 1986-04-22 | Merrell Dow Pharmaceuticals Inc. | Isoquinoline thromboxane synthetase inhibitors |
| ATE68789T1 (de) * | 1985-10-16 | 1991-11-15 | Merck Frosst Canada Inc | 2-substituierte chinoline. |
| GB9615950D0 (en) * | 1996-07-30 | 1996-09-11 | Univ Warwick | Variable reluctance machines |
| US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1064259A (en) * | 1963-12-19 | 1967-04-05 | Union Pharma Scient Appl | New derivatives of 2-anilino-nicotinic acid and process for their preparation |
| GB1162287A (en) * | 1967-11-07 | 1969-08-20 | Union Pharma Scient Appl | New Salts of 2-Anilino-Nicotinic Acids |
| GB1264798A (es) * | 1968-07-10 | 1972-02-23 | ||
| ES416847A1 (es) * | 1973-07-12 | 1976-03-01 | Hermes Sa Lab | Procedimiento para la obtencion de derivados del acido ni- cotinico. |
-
1977
- 1977-08-10 DE DE19772735919 patent/DE2735919A1/de active Granted
-
1978
- 1978-06-27 FI FI782039A patent/FI71555C/fi not_active IP Right Cessation
- 1978-07-07 GR GR56729A patent/GR65024B/el unknown
- 1978-07-28 AT AT0549278A patent/AT370415B/de not_active IP Right Cessation
- 1978-07-28 ES ES472143A patent/ES472143A1/es not_active Expired
- 1978-07-31 PH PH21447A patent/PH19117A/en unknown
- 1978-08-07 MX MX787292U patent/MX5672E/es unknown
- 1978-08-07 CH CH8381/78A patent/CH649289A5/de not_active IP Right Cessation
- 1978-08-08 SU SU782646404A patent/SU735168A3/ru active
- 1978-08-08 BG BG7840623A patent/BG30472A1/xx unknown
- 1978-08-08 LU LU80094A patent/LU80094A1/de unknown
- 1978-08-08 IT IT50642/78A patent/IT1107960B/it active
- 1978-08-08 DD DD78207180A patent/DD140351A5/de unknown
- 1978-08-09 HU HU78BO1727A patent/HU179933B/hu not_active IP Right Cessation
- 1978-08-09 SE SE7808530A patent/SE444170B/sv not_active IP Right Cessation
- 1978-08-09 IE IE1618/78A patent/IE47228B1/en unknown
- 1978-08-09 DK DK351978A patent/DK148019C/da not_active IP Right Cessation
- 1978-08-09 GB GB7832731A patent/GB2002764B/en not_active Expired
- 1978-08-09 ZA ZA784501A patent/ZA784501B/xx unknown
- 1978-08-09 JP JP9626278A patent/JPS5430177A/ja active Granted
- 1978-08-09 CS CS785205A patent/CS202506B2/cs unknown
- 1978-08-09 NO NO782707A patent/NO152605C/no unknown
- 1978-08-09 AU AU38772/78A patent/AU520240B2/en not_active Expired
- 1978-08-09 PL PL1978208942A patent/PL115778B1/pl unknown
- 1978-08-09 PT PT68407A patent/PT68407A/pt unknown
- 1978-08-09 NZ NZ188101A patent/NZ188101A/xx unknown
- 1978-08-09 PL PL1978215270A patent/PL115889B1/pl unknown
- 1978-08-09 CA CA308,978A patent/CA1111037A/en not_active Expired
- 1978-08-09 YU YU1916/78A patent/YU40832B/xx unknown
- 1978-08-09 BE BE78189801A patent/BE869640A/xx not_active IP Right Cessation
- 1978-08-09 NL NL787808319A patent/NL7808319A/xx not_active Application Discontinuation
- 1978-08-10 FR FR7823617A patent/FR2400017A1/fr active Granted
- 1978-11-28 ES ES475456A patent/ES475456A1/es not_active Expired
- 1978-11-28 ES ES475457A patent/ES475457A1/es not_active Expired
-
1979
- 1979-05-16 ES ES480623A patent/ES480623A1/es not_active Expired
- 1979-05-16 ES ES480622A patent/ES480622A1/es not_active Expired
- 1979-05-21 SU SU792765447A patent/SU886743A3/ru active
- 1979-08-07 US US06/064,355 patent/US4241068A/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |