IE40951L - Preparation of 1, 4- diazepines. - Google Patents

Preparation of 1, 4- diazepines.

Info

Publication number
IE40951L
IE40951L IE750699A IE69975A IE40951L IE 40951 L IE40951 L IE 40951L IE 750699 A IE750699 A IE 750699A IE 69975 A IE69975 A IE 69975A IE 40951 L IE40951 L IE 40951L
Authority
IE
Ireland
Prior art keywords
carbon atoms
diazepines
dihydro
phenyl
amino
Prior art date
Application number
IE750699A
Other versions
IE40951B1 (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US456017A external-priority patent/US3929884A/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE40951L publication Critical patent/IE40951L/en
Publication of IE40951B1 publication Critical patent/IE40951B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Novel 5-amino-7-phenyl-2,3-dihydro-1H-1,4-diazepines of the formula I are prepared. <IMAGE> R1, R2 and R3 are, independently of one another, hydrogen, an alkyl group with 1-4 carbon atoms, an alkoxy group with 1-4 carbon atoms, fluorine, chlorine or bromine, or two of the substituents R1, R2 and R3, which are located on adjacent carbon atoms, represent a methylenedioxy group. The compounds of the formula Ia <IMAGE> in which R1 is t-butyl are heated in the presence of free acid for this purpose. The compounds are active against obesity and have an antidiabetic effect. 5-Amino-7-phenyl-2,3-dihydro-1H-1,4-diazepine is preferred. [GB1494433A]
IE699/75A 1974-03-29 1975-03-27 Diazepine derivatives IE40951B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US456017A US3929884A (en) 1974-03-29 1974-03-29 Intermediates in the synthesis of 5-alkylamino-7-phenyl or substituted phenyl-2,3-dihydro-1H-1,4-diazepines
US52834474A 1974-11-29 1974-11-29

Publications (2)

Publication Number Publication Date
IE40951L true IE40951L (en) 1975-09-29
IE40951B1 IE40951B1 (en) 1979-09-12

Family

ID=27038065

Family Applications (1)

Application Number Title Priority Date Filing Date
IE699/75A IE40951B1 (en) 1974-03-29 1975-03-27 Diazepine derivatives

Country Status (15)

Country Link
JP (1) JPS5136482A (en)
AU (1) AU500509B2 (en)
CA (1) CA1064488A (en)
CH (1) CH613696A5 (en)
DE (1) DE2512510A1 (en)
DK (1) DK137127B (en)
ES (1) ES453665A1 (en)
FI (1) FI750827A7 (en)
FR (1) FR2265397B1 (en)
GB (1) GB1494433A (en)
IE (1) IE40951B1 (en)
IL (1) IL46958A (en)
NL (1) NL7503532A (en)
NO (1) NO750978L (en)
SE (1) SE7503278L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0608655D0 (en) * 2006-05-03 2006-06-14 Merck Sharp & Dohme Therapeutic Treatment

Also Published As

Publication number Publication date
IE40951B1 (en) 1979-09-12
DK137127B (en) 1978-01-23
ES453665A1 (en) 1977-11-16
FI750827A7 (en) 1975-09-21
IL46958A (en) 1978-07-31
FR2265397A1 (en) 1975-10-24
SE7503278L (en) 1975-09-30
DE2512510A1 (en) 1975-10-02
IL46958A0 (en) 1975-05-22
CH613696A5 (en) 1979-10-15
CA1064488A (en) 1979-10-16
AU7960175A (en) 1976-09-30
GB1494433A (en) 1977-12-07
NL7503532A (en) 1975-10-01
DK117975A (en) 1975-09-30
FR2265397B1 (en) 1978-08-04
DK137127C (en) 1978-06-26
AU500509B2 (en) 1979-05-24
JPS5136482A (en) 1976-03-27
NO750978L (en) 1975-09-30

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