IE40951B1 - Diazepine derivatives - Google Patents

Diazepine derivatives

Info

Publication number
IE40951B1
IE40951B1 IE699/75A IE69975A IE40951B1 IE 40951 B1 IE40951 B1 IE 40951B1 IE 699/75 A IE699/75 A IE 699/75A IE 69975 A IE69975 A IE 69975A IE 40951 B1 IE40951 B1 IE 40951B1
Authority
IE
Ireland
Prior art keywords
carbon atoms
dihydro
phenyl
amino
compounds
Prior art date
Application number
IE699/75A
Other versions
IE40951L (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US456017A external-priority patent/US3929884A/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE40951L publication Critical patent/IE40951L/en
Publication of IE40951B1 publication Critical patent/IE40951B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Novel 5-amino-7-phenyl-2,3-dihydro-1H-1,4-diazepines of the formula I are prepared. <IMAGE> R1, R2 and R3 are, independently of one another, hydrogen, an alkyl group with 1-4 carbon atoms, an alkoxy group with 1-4 carbon atoms, fluorine, chlorine or bromine, or two of the substituents R1, R2 and R3, which are located on adjacent carbon atoms, represent a methylenedioxy group. The compounds of the formula Ia <IMAGE> in which R1 is t-butyl are heated in the presence of free acid for this purpose. The compounds are active against obesity and have an antidiabetic effect. 5-Amino-7-phenyl-2,3-dihydro-1H-1,4-diazepine is preferred. [GB1494433A]
IE699/75A 1974-03-29 1975-03-27 Diazepine derivatives IE40951B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US456017A US3929884A (en) 1974-03-29 1974-03-29 Intermediates in the synthesis of 5-alkylamino-7-phenyl or substituted phenyl-2,3-dihydro-1H-1,4-diazepines
US52834474A 1974-11-29 1974-11-29

Publications (2)

Publication Number Publication Date
IE40951L IE40951L (en) 1975-09-29
IE40951B1 true IE40951B1 (en) 1979-09-12

Family

ID=27038065

Family Applications (1)

Application Number Title Priority Date Filing Date
IE699/75A IE40951B1 (en) 1974-03-29 1975-03-27 Diazepine derivatives

Country Status (15)

Country Link
JP (1) JPS5136482A (en)
AU (1) AU500509B2 (en)
CA (1) CA1064488A (en)
CH (1) CH613696A5 (en)
DE (1) DE2512510A1 (en)
DK (1) DK137127B (en)
ES (1) ES453665A1 (en)
FI (1) FI750827A (en)
FR (1) FR2265397B1 (en)
GB (1) GB1494433A (en)
IE (1) IE40951B1 (en)
IL (1) IL46958A (en)
NL (1) NL7503532A (en)
NO (1) NO750978L (en)
SE (1) SE7503278L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0608655D0 (en) * 2006-05-03 2006-06-14 Merck Sharp & Dohme Therapeutic Treatment

Also Published As

Publication number Publication date
FR2265397B1 (en) 1978-08-04
IL46958A (en) 1978-07-31
CA1064488A (en) 1979-10-16
AU500509B2 (en) 1979-05-24
NO750978L (en) 1975-09-30
DE2512510A1 (en) 1975-10-02
SE7503278L (en) 1975-09-30
IE40951L (en) 1975-09-29
JPS5136482A (en) 1976-03-27
FR2265397A1 (en) 1975-10-24
AU7960175A (en) 1976-09-30
CH613696A5 (en) 1979-10-15
DK117975A (en) 1975-09-30
DK137127C (en) 1978-06-26
DK137127B (en) 1978-01-23
NL7503532A (en) 1975-10-01
ES453665A1 (en) 1977-11-16
FI750827A (en) 1975-09-21
IL46958A0 (en) 1975-05-22
GB1494433A (en) 1977-12-07

Similar Documents

Publication Publication Date Title
IE782482L (en) Chemical compounds
IE781788L (en) Thienothiazine
ES467494A1 (en) Combating arthropods with 3-phenoxy-fluoro-benzyl carboxylic acid esters
ES464162A1 (en) Derivatives of quinazolone
ES467565A1 (en) 1-(4-Acylamino-phenyl)-2-amino-ethanols and salts thereof
ES462543A1 (en) Substituted 6 - phenyl - 1,2,4 - triazolo-((4,3-b)pyridazines
ES391026A1 (en) Benzonaphthyridine derivatives
ES405983A1 (en) N-fluoroalkylated phenylethylamine
AU8570482A (en) Pyridinecarbinols
IE790996L (en) Phenylaminothiophene derivatives
IE40951B1 (en) Diazepine derivatives
AU536912B2 (en) Benzothiazole derivatives
IE41151L (en) 2-amino -1, 3- thiazines.
ES480623A1 (en) 2-(Pyridyl-amino)-benzoic acids and salts thereof
ES475131A1 (en) 1,4-Benzodiazepines and their salts, process for their preparation and pharmaceutical compositions containing them.
IE812498L (en) Pyrimidine derivatives.
IE41409L (en) 3-piperazino-isoquinoline derivatives
ES470751A1 (en) Morpholino pyridazinylhydrazones
ES456400A1 (en) Thienothiazine derivatives
IE46102L (en) Isoxazole derivatives
ES460807A1 (en) 4,5,6,7-Tetrahalo-isoindolin-1-one derivatives
IE42386L (en) 3-benzyl-pyridazine derivatives.
IE44564L (en) DITHIEPINO [1,4] [2,3-c] PYRROLE DERIVATIVES
ES446329A1 (en) Acetamidoxime compounds
ES465560A1 (en) Phenylalkylamino-alkyl derivatives of quinazolinone and phthalazinone