GB1494433A - Diazepine derivatives - Google Patents

Diazepine derivatives

Info

Publication number
GB1494433A
GB1494433A GB12866/75A GB1286675A GB1494433A GB 1494433 A GB1494433 A GB 1494433A GB 12866/75 A GB12866/75 A GB 12866/75A GB 1286675 A GB1286675 A GB 1286675A GB 1494433 A GB1494433 A GB 1494433A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
dihydro
phenyl
amino
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12866/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US456017A external-priority patent/US3929884A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1494433A publication Critical patent/GB1494433A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Novel 5-amino-7-phenyl-2,3-dihydro-1H-1,4-diazepines of the formula I are prepared. <IMAGE> R1, R2 and R3 are, independently of one another, hydrogen, an alkyl group with 1-4 carbon atoms, an alkoxy group with 1-4 carbon atoms, fluorine, chlorine or bromine, or two of the substituents R1, R2 and R3, which are located on adjacent carbon atoms, represent a methylenedioxy group. The compounds of the formula Ia <IMAGE> in which R1 is t-butyl are heated in the presence of free acid for this purpose. The compounds are active against obesity and have an antidiabetic effect. 5-Amino-7-phenyl-2,3-dihydro-1H-1,4-diazepine is preferred.
GB12866/75A 1974-03-29 1975-03-27 Diazepine derivatives Expired GB1494433A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US456017A US3929884A (en) 1974-03-29 1974-03-29 Intermediates in the synthesis of 5-alkylamino-7-phenyl or substituted phenyl-2,3-dihydro-1H-1,4-diazepines
US52834474A 1974-11-29 1974-11-29

Publications (1)

Publication Number Publication Date
GB1494433A true GB1494433A (en) 1977-12-07

Family

ID=27038065

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12866/75A Expired GB1494433A (en) 1974-03-29 1975-03-27 Diazepine derivatives

Country Status (15)

Country Link
JP (1) JPS5136482A (en)
AU (1) AU500509B2 (en)
CA (1) CA1064488A (en)
CH (1) CH613696A5 (en)
DE (1) DE2512510A1 (en)
DK (1) DK137127B (en)
ES (1) ES453665A1 (en)
FI (1) FI750827A (en)
FR (1) FR2265397B1 (en)
GB (1) GB1494433A (en)
IE (1) IE40951B1 (en)
IL (1) IL46958A (en)
NL (1) NL7503532A (en)
NO (1) NO750978L (en)
SE (1) SE7503278L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007129111A1 (en) * 2006-05-03 2007-11-15 Merck Sharp & Dohme Limited Diazepine derivatives as 5-ht2a antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007129111A1 (en) * 2006-05-03 2007-11-15 Merck Sharp & Dohme Limited Diazepine derivatives as 5-ht2a antagonists

Also Published As

Publication number Publication date
JPS5136482A (en) 1976-03-27
DE2512510A1 (en) 1975-10-02
FR2265397B1 (en) 1978-08-04
AU500509B2 (en) 1979-05-24
FR2265397A1 (en) 1975-10-24
IL46958A0 (en) 1975-05-22
CA1064488A (en) 1979-10-16
ES453665A1 (en) 1977-11-16
SE7503278L (en) 1975-09-30
IE40951B1 (en) 1979-09-12
IE40951L (en) 1975-09-29
IL46958A (en) 1978-07-31
NL7503532A (en) 1975-10-01
NO750978L (en) 1975-09-30
DK117975A (en) 1975-09-30
CH613696A5 (en) 1979-10-15
DK137127C (en) 1978-06-26
AU7960175A (en) 1976-09-30
DK137127B (en) 1978-01-23
FI750827A (en) 1975-09-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee