ES391026A1 - Procedimiento para la obtencion de benzonaftiridina. - Google Patents
Procedimiento para la obtencion de benzonaftiridina.Info
- Publication number
- ES391026A1 ES391026A1 ES391026A ES391026A ES391026A1 ES 391026 A1 ES391026 A1 ES 391026A1 ES 391026 A ES391026 A ES 391026A ES 391026 A ES391026 A ES 391026A ES 391026 A1 ES391026 A1 ES 391026A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- hydrogen
- chlorine
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BJVCSICIEDHBNI-UHFFFAOYSA-N benzo[b][1,8]naphthyridine Chemical class N1=CC=CC2=CC3=CC=CC=C3N=C21 BJVCSICIEDHBNI-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- SWJXWSAKHXBQSY-UHFFFAOYSA-N benzo(c)cinnoline Chemical compound C1=CC=C2C3=CC=CC=C3N=NC2=C1 SWJXWSAKHXBQSY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- -1 methylenedioxy Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical class C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH708670A CH527196A (de) | 1970-05-13 | 1970-05-13 | Verfahren zur Herstellung neuer Benzonaphthyridinderivate |
| CH708970A CH527822A (de) | 1970-05-13 | 1970-05-13 | Verfahren zur Herstellung neuer Benzonaphtyridin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES391026A1 true ES391026A1 (es) | 1974-04-01 |
Family
ID=25700728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391026A Expired ES391026A1 (es) | 1970-05-13 | 1971-05-11 | Procedimiento para la obtencion de benzonaftiridina. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5432799B1 (enExample) |
| AT (1) | AT326674B (enExample) |
| CA (1) | CA970377A (enExample) |
| CS (2) | CS167202B2 (enExample) |
| DE (1) | DE2123328A1 (enExample) |
| DK (1) | DK134488B (enExample) |
| ES (1) | ES391026A1 (enExample) |
| FI (1) | FI52089C (enExample) |
| FR (1) | FR2100649B1 (enExample) |
| GB (1) | GB1361441A (enExample) |
| NL (1) | NL7106502A (enExample) |
| PL (1) | PL76913B1 (enExample) |
| SE (1) | SE387640B (enExample) |
| SU (1) | SU423296A3 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899494A (en) * | 1970-05-13 | 1975-08-12 | Sandoz Ltd | Substituted 6-phenyl benzo-naphthyridines |
| NL7314396A (enExample) * | 1972-10-26 | 1974-05-01 | ||
| BE880455A (fr) * | 1979-01-22 | 1980-06-06 | Sandoz Sa | Compositions pharmaceutiques a base d'une benzo (c) (1,6) naphtyridine |
| US6384047B1 (en) | 1997-06-03 | 2002-05-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine |
| SK287231B6 (sk) | 1999-08-21 | 2010-04-07 | Nycomed Gmbh | Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2004087211A2 (en) | 2003-04-01 | 2004-10-14 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| BRPI0510951A (pt) * | 2004-05-12 | 2007-11-20 | Pfizer Prod Inc | derivados de piperidina como antagonistas de nk1 e nk3 |
| EP2170930B3 (en) | 2007-06-04 | 2013-10-02 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CN103764672A (zh) | 2011-03-01 | 2014-04-30 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| RS65632B1 (sr) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Ltd | Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe |
| CN114404588A (zh) | 2013-08-09 | 2022-04-29 | 阿德利克斯公司 | 用于抑制磷酸盐转运的化合物和方法 |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
-
1971
- 1971-05-10 GB GB1398471A patent/GB1361441A/en not_active Expired
- 1971-05-11 ES ES391026A patent/ES391026A1/es not_active Expired
- 1971-05-11 CS CS920771A patent/CS167202B2/cs unknown
- 1971-05-11 FI FI129371A patent/FI52089C/fi active
- 1971-05-11 PL PL14807271A patent/PL76913B1/pl unknown
- 1971-05-11 CS CS341671A patent/CS162753B2/cs unknown
- 1971-05-11 SU SU1656559A patent/SU423296A3/ru active
- 1971-05-11 DK DK225771A patent/DK134488B/da unknown
- 1971-05-11 DE DE19712123328 patent/DE2123328A1/de not_active Ceased
- 1971-05-12 AT AT412471A patent/AT326674B/de not_active IP Right Cessation
- 1971-05-12 SE SE613471A patent/SE387640B/xx unknown
- 1971-05-12 CA CA112,767A patent/CA970377A/en not_active Expired
- 1971-05-12 JP JP3189471A patent/JPS5432799B1/ja active Pending
- 1971-05-12 NL NL7106502A patent/NL7106502A/xx not_active Application Discontinuation
- 1971-05-12 FR FR7117124A patent/FR2100649B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE387640B (sv) | 1976-09-13 |
| CS167202B2 (enExample) | 1976-04-29 |
| CS162753B2 (enExample) | 1975-07-15 |
| AT326674B (de) | 1975-12-29 |
| JPS5432799B1 (enExample) | 1979-10-16 |
| FR2100649B1 (enExample) | 1974-08-30 |
| DE2123328A1 (de) | 1971-12-02 |
| NL7106502A (enExample) | 1971-11-16 |
| GB1361441A (en) | 1974-07-24 |
| FR2100649A1 (enExample) | 1972-03-24 |
| FI52089B (enExample) | 1977-02-28 |
| FI52089C (fi) | 1977-06-10 |
| SU423296A3 (ru) | 1974-04-05 |
| ATA412471A (de) | 1975-03-15 |
| DK134488C (enExample) | 1977-05-16 |
| PL76913B1 (en) | 1975-02-28 |
| CA970377A (en) | 1975-07-01 |
| DK134488B (da) | 1976-11-15 |
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