ES432952A1 - Procedimiento para preparar derivado de vincamina. - Google Patents

Procedimiento para preparar derivado de vincamina.

Info

Publication number
ES432952A1
ES432952A1 ES432952A ES432952A ES432952A1 ES 432952 A1 ES432952 A1 ES 432952A1 ES 432952 A ES432952 A ES 432952A ES 432952 A ES432952 A ES 432952A ES 432952 A1 ES432952 A1 ES 432952A1
Authority
ES
Spain
Prior art keywords
formula
lower alkyl
bromine
chlorine
fluorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES432952A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1768973A external-priority patent/CH588488A5/de
Priority claimed from CH162174A external-priority patent/CH596207A5/de
Priority claimed from CH176574A external-priority patent/CH593283A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES432952A1 publication Critical patent/ES432952A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES432952A 1973-12-18 1974-12-16 Procedimiento para preparar derivado de vincamina. Expired ES432952A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1768973A CH588488A5 (en) 1973-12-18 1973-12-18 Vincamine derivs for treating behaviour disorders - by ring closure of indoloquinolizine deriv
CH162174A CH596207A5 (en) 1974-02-06 1974-02-06 Vincamine derivs for treating behaviour disorders
CH176574A CH593283A5 (en) 1974-02-08 1974-02-08 Vincamine derivs for treating behaviour disorders - by ring closure of indoloquinolizine deriv

Publications (1)

Publication Number Publication Date
ES432952A1 true ES432952A1 (es) 1977-02-16

Family

ID=27173122

Family Applications (3)

Application Number Title Priority Date Filing Date
ES432952A Expired ES432952A1 (es) 1973-12-18 1974-12-16 Procedimiento para preparar derivado de vincamina.
ES450740A Expired ES450740A1 (es) 1973-12-18 1976-08-16 Procedimiento para preparar derivados de vincamina.
ES450741A Expired ES450741A1 (es) 1973-12-18 1976-08-16 Procedimiento para preparar derivados de vincamina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES450740A Expired ES450740A1 (es) 1973-12-18 1976-08-16 Procedimiento para preparar derivados de vincamina.
ES450741A Expired ES450741A1 (es) 1973-12-18 1976-08-16 Procedimiento para preparar derivados de vincamina.

Country Status (16)

Country Link
JP (1) JPS5817474B2 (es)
CA (1) CA1051899A (es)
DD (1) DD116043A5 (es)
DE (1) DE2458164A1 (es)
DK (1) DK139358B (es)
ES (3) ES432952A1 (es)
FI (1) FI59096C (es)
FR (1) FR2254342B1 (es)
GB (1) GB1492579A (es)
HK (1) HK53980A (es)
IE (1) IE40791B1 (es)
MY (1) MY8100186A (es)
NL (1) NL7416237A (es)
NO (1) NO744456L (es)
PH (1) PH12927A (es)
SE (1) SE422798B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2396759A1 (fr) * 1977-07-06 1979-02-02 Omnium Chimique Sa Nouveaux composes heterocycliques, derives de la vincamine, leur preparation et leur application comme medicaments, notamment dans le domaine des insuffisances cardio-circulatoires, cerebro-vasculaires ou respiratoires
HU177498B (en) * 1977-07-27 1981-10-28 Richter Gedeon Vegyeszet Process for preparing new vincinic acid and apovincinic acid esters
FR2423493A1 (fr) * 1977-10-19 1979-11-16 Omnium Chimique Sa Nouveaux composes heterocycliques derives de l'apo-vincamine, leur preparation et leur application comme medicaments, notamment dans le domaine des insuffisances cardio-circulatoires, cerebro-vasculaires et respiratoires
FR2407931A1 (fr) * 1977-11-02 1979-06-01 Synthelabo Derives de l'eburnamenine et leur application en therapeutique
JPS5493000A (en) * 1977-12-28 1979-07-23 Sandoz Ag Improvement of organic compound
DE2800063A1 (de) * 1978-01-02 1979-07-12 Sandoz Ag 10-bromvincamin, seine herstellung und verwendung
US4283401A (en) * 1978-07-12 1981-08-11 Richter Gedeon Vegyeszeti Gyar Rt Process for the preparation of 11-bromo-vincaminic acid ester derivatives and their use in protecting animals against cerebral hypoxy
US4315011A (en) * 1978-07-12 1982-02-09 Richter Gedeon Vegyeszeti Gyar Rt. 1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow
US4285949A (en) * 1978-12-11 1981-08-25 Omnichem Societe Anonyme Vincamine derivatives, their preparation and therapeutical use
HU177732B (en) * 1978-12-15 1981-12-28 Richter Gedeon Vegyeszet Process for producing 10-bromo-vincamine and acid additional salts thereof,and 10-bromo-14-epivincamine
HU180928B (en) * 1979-08-06 1983-05-30 Richter Gedeon Vegyeszet Process for preparing new brominated 15-hydroxy-e-homo-eburane derivatives
HU180929B (en) * 1979-08-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing new bromo-vincamone derivatives
HU185305B (en) * 1981-08-23 1985-01-28 Richter Gedeon Vegyeszet Process for preparing vincine and apovincine
HU183326B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted in the a ring and acid addition salts thereof
ES8604952A1 (es) * 1985-11-05 1986-03-16 Covex Sa Procedimiento para la preparacion de los compuestos 10-11 bromo-14,15-dihidro-14 b-hidroxi-(3x,16x)-eburnamenina-14- carboxilato de metilo
US4883876A (en) * 1987-09-07 1989-11-28 Taisho Pharmaceutical Co., Ltd. Acylated vincaminic acid derivatives

Also Published As

Publication number Publication date
CA1051899A (en) 1979-04-03
FI59096C (fi) 1981-06-10
DD116043A5 (es) 1975-11-05
FI59096B (fi) 1981-02-27
DE2458164C2 (es) 1991-04-18
JPS50105700A (es) 1975-08-20
IE40791B1 (en) 1979-08-15
JPS5817474B2 (ja) 1983-04-07
HK53980A (en) 1980-10-03
DE2458164A1 (de) 1975-06-26
AU7648374A (en) 1976-06-17
NL7416237A (nl) 1975-06-20
SE422798B (sv) 1982-03-29
FR2254342B1 (es) 1978-07-21
DK139358B (da) 1979-02-05
IE40791L (en) 1975-06-18
GB1492579A (en) 1977-11-23
FR2254342A1 (es) 1975-07-11
NO744456L (es) 1975-07-14
SE7415416L (es) 1975-06-19
ES450740A1 (es) 1977-12-16
DK139358C (es) 1979-07-09
DK639774A (es) 1975-08-25
FI355274A (es) 1975-06-19
MY8100186A (en) 1981-12-31
PH12927A (en) 1979-10-10
ES450741A1 (es) 1978-03-16

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