DK134488B - Analogifremgangsmåde til fremstilling af i stillingerne 4a, 10b cis-konfigurerede benzo/c//1,6/naphthyridinderivater eller syreadditionssalte deraf. - Google Patents
Analogifremgangsmåde til fremstilling af i stillingerne 4a, 10b cis-konfigurerede benzo/c//1,6/naphthyridinderivater eller syreadditionssalte deraf.Info
- Publication number
- DK134488B DK134488B DK225771A DK225771A DK134488B DK 134488 B DK134488 B DK 134488B DK 225771 A DK225771 A DK 225771A DK 225771 A DK225771 A DK 225771A DK 134488 B DK134488 B DK 134488B
- Authority
- DK
- Denmark
- Prior art keywords
- benzo
- cis
- positions
- preparation
- acid addition
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 125000005605 benzo group Chemical group 0.000 title 1
- 150000005054 naphthyridines Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH708670A CH527196A (de) | 1970-05-13 | 1970-05-13 | Verfahren zur Herstellung neuer Benzonaphthyridinderivate |
| CH708970A CH527822A (de) | 1970-05-13 | 1970-05-13 | Verfahren zur Herstellung neuer Benzonaphtyridin-Derivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK134488B true DK134488B (da) | 1976-11-15 |
| DK134488C DK134488C (da) | 1977-05-16 |
Family
ID=25700728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK225771A DK134488B (da) | 1970-05-13 | 1971-05-11 | Analogifremgangsmåde til fremstilling af i stillingerne 4a, 10b cis-konfigurerede benzo/c//1,6/naphthyridinderivater eller syreadditionssalte deraf. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5432799B1 (da) |
| AT (1) | AT326674B (da) |
| CA (1) | CA970377A (da) |
| CS (2) | CS167202B2 (da) |
| DE (1) | DE2123328A1 (da) |
| DK (1) | DK134488B (da) |
| ES (1) | ES391026A1 (da) |
| FI (1) | FI52089C (da) |
| FR (1) | FR2100649B1 (da) |
| GB (1) | GB1361441A (da) |
| NL (1) | NL7106502A (da) |
| PL (1) | PL76913B1 (da) |
| SE (1) | SE387640B (da) |
| SU (1) | SU423296A3 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899494A (en) * | 1970-05-13 | 1975-08-12 | Sandoz Ltd | Substituted 6-phenyl benzo-naphthyridines |
| NL7314396A (da) * | 1972-10-26 | 1974-05-01 | ||
| BE880455A (fr) * | 1979-01-22 | 1980-06-06 | Sandoz Sa | Compositions pharmaceutiques a base d'une benzo (c) (1,6) naphtyridine |
| CA2291153A1 (en) * | 1997-06-03 | 1998-12-10 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine |
| CZ302882B6 (cs) | 1999-08-21 | 2012-01-04 | Nycomed Gmbh | Farmaceutický prostredek |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7153824B2 (en) | 2003-04-01 | 2006-12-26 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| MXPA06013162A (es) * | 2004-05-12 | 2007-02-13 | Pfizer Prod Inc | Derivados de piperidina como antagonistas de neurocinina 1 y neurocinina 3. |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EA201391254A1 (ru) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| EP3492106B1 (en) | 2013-08-09 | 2021-02-17 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
-
1971
- 1971-05-10 GB GB1398471A patent/GB1361441A/en not_active Expired
- 1971-05-11 CS CS920771A patent/CS167202B2/cs unknown
- 1971-05-11 FI FI129371A patent/FI52089C/fi active
- 1971-05-11 DE DE19712123328 patent/DE2123328A1/de not_active Ceased
- 1971-05-11 PL PL14807271A patent/PL76913B1/pl unknown
- 1971-05-11 CS CS341671A patent/CS162753B2/cs unknown
- 1971-05-11 DK DK225771A patent/DK134488B/da unknown
- 1971-05-11 ES ES391026A patent/ES391026A1/es not_active Expired
- 1971-05-11 SU SU1656559A patent/SU423296A3/ru active
- 1971-05-12 JP JP3189471A patent/JPS5432799B1/ja active Pending
- 1971-05-12 SE SE613471A patent/SE387640B/xx unknown
- 1971-05-12 AT AT412471A patent/AT326674B/de not_active IP Right Cessation
- 1971-05-12 FR FR7117124A patent/FR2100649B1/fr not_active Expired
- 1971-05-12 CA CA112,767A patent/CA970377A/en not_active Expired
- 1971-05-12 NL NL7106502A patent/NL7106502A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AT326674B (de) | 1975-12-29 |
| CS167202B2 (da) | 1976-04-29 |
| ES391026A1 (es) | 1974-04-01 |
| CA970377A (en) | 1975-07-01 |
| FI52089C (fi) | 1977-06-10 |
| ATA412471A (de) | 1975-03-15 |
| FR2100649B1 (da) | 1974-08-30 |
| FI52089B (da) | 1977-02-28 |
| SU423296A3 (ru) | 1974-04-05 |
| DE2123328A1 (de) | 1971-12-02 |
| NL7106502A (da) | 1971-11-16 |
| JPS5432799B1 (da) | 1979-10-16 |
| DK134488C (da) | 1977-05-16 |
| PL76913B1 (en) | 1975-02-28 |
| SE387640B (sv) | 1976-09-13 |
| FR2100649A1 (da) | 1972-03-24 |
| GB1361441A (en) | 1974-07-24 |
| CS162753B2 (da) | 1975-07-15 |
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