ES3068436T3 - Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer - Google Patents

Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer

Info

Publication number
ES3068436T3
ES3068436T3 ES20807962T ES20807962T ES3068436T3 ES 3068436 T3 ES3068436 T3 ES 3068436T3 ES 20807962 T ES20807962 T ES 20807962T ES 20807962 T ES20807962 T ES 20807962T ES 3068436 T3 ES3068436 T3 ES 3068436T3
Authority
ES
Spain
Prior art keywords
cancer
mmol
compound
methylpyridin
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20807962T
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English (en)
Spanish (es)
Inventor
Hui-Ling Wang
Victor J Cee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
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Filing date
Publication date
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Publication of ES3068436T3 publication Critical patent/ES3068436T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES20807962T 2019-10-24 2020-10-22 Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer Active ES3068436T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962925657P 2019-10-24 2019-10-24
PCT/US2020/056874 WO2021081212A1 (en) 2019-10-24 2020-10-22 Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer

Publications (1)

Publication Number Publication Date
ES3068436T3 true ES3068436T3 (en) 2026-05-29

Family

ID=73452299

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20807962T Active ES3068436T3 (en) 2019-10-24 2020-10-22 Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer

Country Status (8)

Country Link
US (1) US20240190862A1 (enExample)
EP (2) EP4684786A3 (enExample)
JP (1) JP7634003B2 (enExample)
AU (1) AU2020369569B2 (enExample)
CA (1) CA3155857A1 (enExample)
ES (1) ES3068436T3 (enExample)
MX (1) MX428369B (enExample)
WO (1) WO2021081212A1 (enExample)

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