ES3004083T3 - Mass spectrometry assay method for detection and quantitation of kidney function metabolites - Google Patents

Mass spectrometry assay method for detection and quantitation of kidney function metabolites Download PDF

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Publication number
ES3004083T3
ES3004083T3 ES17885159T ES17885159T ES3004083T3 ES 3004083 T3 ES3004083 T3 ES 3004083T3 ES 17885159 T ES17885159 T ES 17885159T ES 17885159 T ES17885159 T ES 17885159T ES 3004083 T3 ES3004083 T3 ES 3004083T3
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analytes
ion
analyte
tryptophan
mobile phase
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Spanish (es)
Inventor
Lisa Ford
Tiffany Freed
Deirdre Hauser
Kelli Goodman
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Metabolon Inc
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Metabolon Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/62—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving urea
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0009—Calibration of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7057—(Intracellular) signaling and trafficking pathways
    • G01N2800/7066—Metabolic pathways
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
ES17885159T 2016-12-19 2017-12-14 Mass spectrometry assay method for detection and quantitation of kidney function metabolites Active ES3004083T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662435967P 2016-12-19 2016-12-19
US201762526043P 2017-06-28 2017-06-28
US201762558014P 2017-09-13 2017-09-13
PCT/US2017/066364 WO2018118630A1 (en) 2016-12-19 2017-12-14 Mass spectrometry assay method for detection and quantitation of kidney function metabolites

Publications (1)

Publication Number Publication Date
ES3004083T3 true ES3004083T3 (en) 2025-03-11

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ES17885159T Active ES3004083T3 (en) 2016-12-19 2017-12-14 Mass spectrometry assay method for detection and quantitation of kidney function metabolites

Country Status (8)

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US (1) US11619636B2 (cg-RX-API-DMAC10.html)
EP (1) EP3555615B9 (cg-RX-API-DMAC10.html)
JP (1) JP7393206B2 (cg-RX-API-DMAC10.html)
CN (1) CN110088615B (cg-RX-API-DMAC10.html)
AU (1) AU2017382744B2 (cg-RX-API-DMAC10.html)
CA (1) CA3045022C (cg-RX-API-DMAC10.html)
ES (1) ES3004083T3 (cg-RX-API-DMAC10.html)
WO (1) WO2018118630A1 (cg-RX-API-DMAC10.html)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3004083T3 (en) 2016-12-19 2025-03-11 Metabolon Inc Mass spectrometry assay method for detection and quantitation of kidney function metabolites
CN112689755A (zh) * 2018-09-11 2021-04-20 梅塔博隆股份有限公司 用于检测和定量微生物区系相关代谢物的质谱测定法
US20220189751A1 (en) * 2019-04-24 2022-06-16 Shimadzu Corporation Imaging mass spectrometer
CN113892029A (zh) * 2019-05-31 2022-01-04 梅塔博隆股份有限公司 用于检测代谢物的质谱分析方法
CN112946150B (zh) * 2019-11-26 2024-06-18 深圳华大临床检验中心 一种快速检测人体尿液中高香草酸、香草扁桃酸、5-羟基吲哚乙酸及肌酐的方法及试剂盒
CN111007173A (zh) * 2019-12-20 2020-04-14 辉源生物科技（上海）有限公司 吲哚胺2，3-二氧化酶抑制剂的筛选方法
CN115917323A (zh) * 2020-05-19 2023-04-04 赛诺菲 使用干血样验证药物水平的方法
CN114026427B (zh) * 2020-05-19 2023-11-17 深圳市中医院 诊断肾病的标志物以及诊断方法
CN114518413B (zh) * 2020-11-18 2024-12-31 江苏天士力帝益药业有限公司 一种卡托普利原料药中脯氨酸的含量测定方法
CN114216984B (zh) * 2021-12-16 2023-10-13 川北医学院附属医院 一种骨质疏松症负离子诊断标志物及其检测方法
CN114414700A (zh) * 2022-01-27 2022-04-29 重庆迪纳利医药科技有限责任公司 一种同时测定生物样品中多种内源性糖醇含量的方法和系统
WO2025244008A1 (ja) * 2024-05-23 2025-11-27 株式会社島津製作所 測定方法、プログラム、および高速液体クロマトグラフタンデム質量分析装置

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US20090194685A1 (en) 2008-01-31 2009-08-06 Mds Analytical Technologies High-throughput screening of metabolic disorders using a laser desorption ion source coupled to a mass analyzer
JP5624709B2 (ja) * 2008-03-13 2014-11-12 大日本住友製薬株式会社 内因性代謝物の分析方法
WO2010126146A1 (ja) 2009-04-30 2010-11-04 Tanaka Noriaki 腎疾患重篤度を判定する方法又は装置若しくはその作動方法
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JP6404834B2 (ja) * 2013-01-31 2018-10-17 メタボロン，インコーポレイテッド インスリン抵抗性の進行に関連するバイオマーカー及びこれを使用する方法
EP3410115A1 (en) 2013-05-14 2018-12-05 Metabolon, Inc. Tryptophan as a biomarkers for kidney function and methods using the same
CN109813914A (zh) * 2013-06-07 2019-05-28 皮尔斯生物科技有限公司 通过质谱分析用复用内标物对蛋白质和蛋白质修饰的绝对定量
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ES3004083T3 (en) 2016-12-19 2025-03-11 Metabolon Inc Mass spectrometry assay method for detection and quantitation of kidney function metabolites

Also Published As

Publication number Publication date
JP2020502544A (ja) 2020-01-23
CN110088615A (zh) 2019-08-02
US11619636B2 (en) 2023-04-04
EP3555615A1 (en) 2019-10-23
JP7393206B2 (ja) 2023-12-06
EP3555615A4 (en) 2020-11-04
CA3045022C (en) 2024-01-16
CA3045022A1 (en) 2018-06-28
US20190346455A1 (en) 2019-11-14
WO2018118630A1 (en) 2018-06-28
EP3555615B1 (en) 2024-10-30
EP3555615B9 (en) 2025-03-19
CN110088615B (zh) 2023-08-22
AU2017382744B2 (en) 2023-02-09
AU2017382744A1 (en) 2019-06-13

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