ES2987225T3 - Modulación de la expresión de UBE3A-ATS - Google Patents
Modulación de la expresión de UBE3A-ATS Download PDFInfo
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- ES2987225T3 ES2987225T3 ES20182895T ES20182895T ES2987225T3 ES 2987225 T3 ES2987225 T3 ES 2987225T3 ES 20182895 T ES20182895 T ES 20182895T ES 20182895 T ES20182895 T ES 20182895T ES 2987225 T3 ES2987225 T3 ES 2987225T3
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- ube3a
- modified
- antisense
- ats
- nucleic acid
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Applications Claiming Priority (5)
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| US201261664083P | 2012-06-25 | 2012-06-25 | |
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| US201361750939P | 2013-01-10 | 2013-01-10 | |
| US201361755617P | 2013-01-23 | 2013-01-23 | |
| US201361772925P | 2013-03-05 | 2013-03-05 |
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| ES18188705T Active ES2809199T3 (es) | 2012-06-25 | 2013-06-25 | Modulación de la expresión de UBE3A-ATS |
| ES13809694.6T Active ES2688831T3 (es) | 2012-06-25 | 2013-06-25 | Modulación de la expresión de UBE3A-ATS |
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| ES13809694.6T Active ES2688831T3 (es) | 2012-06-25 | 2013-06-25 | Modulación de la expresión de UBE3A-ATS |
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| DK2864479T3 (en) | 2012-06-25 | 2018-10-22 | Ionis Pharmaceuticals Inc | MODULATION OF UBE3A-ATS EXPRESSION |
| US10400243B2 (en) | 2014-11-25 | 2019-09-03 | Ionis Pharmaceuticals, Inc. | Modulation of UBE3A-ATS expression |
| EP3291843B1 (en) | 2015-05-07 | 2023-03-22 | University of South Florida | Modified ube3a gene for a gene therapy approach for angelman syndrome |
| UA125963C2 (uk) * | 2015-11-12 | 2022-07-20 | Ф. Хоффманн-Ля Рош Аг | Олігонуклеотид для індукції батьківської експресії ube3a |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| BR112020009431A2 (pt) * | 2017-12-01 | 2020-10-13 | The Texas A&M University System | tratamento antisense da síndrome de angelman |
| WO2019168950A1 (en) * | 2018-02-27 | 2019-09-06 | The University Of North Carolina At Chapel Hill | Methods and compositions for treating angelman syndrome |
| CN112739353A (zh) | 2018-06-14 | 2021-04-30 | 奥维德医疗公司 | Mir-92a或mir-145在治疗安格曼综合征中的用途 |
| WO2020061528A1 (en) | 2018-09-21 | 2020-03-26 | University Of Connecticut | Compositions and methods to restore paternal ube3a gene expression in human angelman syndrome |
| WO2020148310A1 (en) | 2019-01-17 | 2020-07-23 | F. Hoffmann-La Roche Ag | E3 ubiquitin ligase (ube3a) protein targets |
| CN117431244A (zh) * | 2019-03-29 | 2024-01-23 | Ionis制药公司 | 用于调节ube3a-ats的化合物和方法 |
| JP7616668B2 (ja) * | 2019-05-22 | 2025-01-17 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | Ｕｂｅ３ａ遺伝子および発現カセットならびにそれらの使用 |
| US12310947B2 (en) | 2019-07-16 | 2025-05-27 | The University Of North Carolina At Chapel Hill | Methods and compositions for unsilencing imprinted genes |
| GB201912103D0 (en) * | 2019-08-22 | 2019-10-09 | Univ Oxford Innovation Ltd | Method of haplotyping |
| WO2021126087A1 (en) | 2019-12-18 | 2021-06-24 | National University Of Singapore | Method for treating angelman syndrome and related disorders |
| EP4142802A4 (en) * | 2020-04-28 | 2024-07-24 | The Trustees of The University of Pennsylvania | COMPOSITIONS AND USES THEREOF FOR THE TREATMENT OF ANGELMAN SYNDROME |
| US20240318198A1 (en) * | 2021-02-03 | 2024-09-26 | The Board Of Regents Of The University Of Texas System | Gene therapy for angelman syndrome |
| US20240240179A1 (en) * | 2021-05-05 | 2024-07-18 | The General Hospital Corporation | Therapy for treatment of prader-willi syndrome |
| WO2023168000A1 (en) * | 2022-03-03 | 2023-09-07 | The Regents Of The University Of California | Compositions and methods for treatment of angelman syndrome |
| TW202536178A (zh) * | 2023-11-09 | 2025-09-16 | 美商Ionis製藥公司 | 用於調節ｕｂｅ３ａ－ａｔｓ之方法 |
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2013
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- 2013-06-25 HU HUE18188705A patent/HUE051698T2/hu unknown
- 2013-06-25 PL PL18188705T patent/PL3461895T3/pl unknown
- 2013-06-25 ES ES20182895T patent/ES2987225T3/es active Active
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- 2013-06-25 EP EP18188705.0A patent/EP3461895B1/en not_active Revoked
- 2013-06-25 ES ES18188705T patent/ES2809199T3/es active Active
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| ES2688831T3 (es) | 2018-11-07 |
| DK3461895T3 (da) | 2020-07-20 |
| EP3770258A1 (en) | 2021-01-27 |
| EP3770258B1 (en) | 2024-07-17 |
| EP3461895A1 (en) | 2019-04-03 |
| PT3461895T (pt) | 2020-09-08 |
| CA2877905A1 (en) | 2014-01-03 |
| EP2864479A4 (en) | 2016-06-08 |
| PL3461895T3 (pl) | 2021-01-11 |
| SI3461895T1 (sl) | 2020-10-30 |
| WO2014004572A2 (en) | 2014-01-03 |
| WO2014004572A3 (en) | 2014-05-01 |
| EP4458361A3 (en) | 2025-01-22 |
| DK2864479T3 (en) | 2018-10-22 |
| US20150191723A1 (en) | 2015-07-09 |
| AU2013280474B2 (en) | 2019-01-03 |
| JP2015529635A (ja) | 2015-10-08 |
| HUE051698T2 (hu) | 2021-03-29 |
| EP2864479A2 (en) | 2015-04-29 |
| AU2013280474A1 (en) | 2015-01-22 |
| EP2864479B1 (en) | 2018-08-15 |
| EP4458361A2 (en) | 2024-11-06 |
| US9617539B2 (en) | 2017-04-11 |
| EP3461895B1 (en) | 2020-07-01 |
| LT3461895T (lt) | 2020-09-10 |
| ES2809199T3 (es) | 2021-03-03 |
| JP6294876B2 (ja) | 2018-03-14 |
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