ES2983609T3 - Anticuerpos ANTI-IL-33 y usos de los mismos - Google Patents
Anticuerpos ANTI-IL-33 y usos de los mismos Download PDFInfo
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Landscapes
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| EP4011913A1 (en) | 2011-06-30 | 2022-06-15 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| EP2762493B1 (en) | 2011-09-30 | 2021-06-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| EP2787081A4 (en) | 2011-11-30 | 2015-10-07 | Chugai Pharmaceutical Co Ltd | PHARMACEUTICAL CARRIER IN CELLS FOR THE FORMATION OF AN IMMUNOMOPLEX |
| AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| ES2701093T3 (es) | 2012-08-21 | 2019-02-20 | Sanofi Biotechnology | Métodos para tratar o prevenir el asma administrando un antagonista de IL-4R |
| EP3721900A1 (en) | 2012-08-24 | 2020-10-14 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc region variant |
| WO2014104165A1 (ja) | 2012-12-27 | 2014-07-03 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| KR20150127591A (ko) | 2013-03-15 | 2015-11-17 | 리제너론 파아마슈티컬스, 인크. | Il-33 길항제 및 이의 용도 |
| TWI636062B (zh) | 2013-04-02 | 2018-09-21 | 中外製藥股份有限公司 | Fc region variant |
| RU2709722C1 (ru) | 2013-12-26 | 2019-12-19 | Мицубиси Танабе Фарма Корпорейшн | Нейтрализующие моноклональные человеческие антитела против интерлейкина-33 |
| US10059764B2 (en) * | 2014-01-10 | 2018-08-28 | Anaptysbio, Inc. | Antibodies directed against interleukin-33 (IL-33) and methods of making and using |
| EP3134120B1 (en) | 2014-04-21 | 2024-01-24 | The Children's Hospital of Philadelphia | Compositions and methods for treating cytokine-related disorders |
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| CA2963991A1 (en) | 2014-09-29 | 2016-04-07 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| CN107109494B (zh) | 2014-11-10 | 2023-10-27 | 豪夫迈·罗氏有限公司 | Il-33介导型疾病的治疗方法和诊断方法 |
| SG11201703767XA (en) | 2014-11-10 | 2017-06-29 | Genentech Inc | Anti-interleukin-33 antibodies and uses thereof |
| JP6227191B1 (ja) | 2014-12-19 | 2017-11-08 | 中外製薬株式会社 | 抗ミオスタチン抗体、変異Fc領域を含むポリペプチド、および使用方法 |
| CN112142844B (zh) | 2015-02-05 | 2025-07-25 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用 |
| US20180036404A1 (en) | 2015-03-02 | 2018-02-08 | 180 Therapeutics Lp | Method of treating a localized fibrotic disorder using a tnf receptor 2 antagonist |
| JP6862351B2 (ja) * | 2015-03-31 | 2021-04-21 | メドイミューン・リミテッドMedImmune Limited | 新規il33型、変異型のil33、抗体、アッセイ及びそれらの使用方法 |
| CA3129007A1 (en) * | 2015-04-06 | 2016-10-13 | Eli N. Glezer | High throughput system for performing assays using electrochemiluminescence including a consumable shaking apparatus |
| TWI870789B (zh) | 2015-08-04 | 2025-01-21 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| EP3359567A2 (en) * | 2015-10-06 | 2018-08-15 | Regeneron Pharmaceuticals, Inc. | Biomarkers related to interleukin-33 (il-33)-mediated diseases and uses thereof |
| EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE |
| BR112018014247A2 (pt) * | 2016-01-14 | 2018-12-18 | Anaptysbio Inc | inibição de reação alérgica usando um inibidor il-33 |
| WO2017184619A2 (en) | 2016-04-18 | 2017-10-26 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human cd40 and uses thereof |
| MA45294A (fr) * | 2016-04-22 | 2019-02-27 | Medimmune Llc | Plasticité fonctionnelle d'ilc2, immunité et copd |
| MX2018013038A (es) * | 2016-04-27 | 2019-03-28 | Pfizer | Anticuerpos anti-il-33, composiciones, metodos y usos de los mismos. |
| SI3448391T1 (sl) | 2016-04-27 | 2024-08-30 | AbbVie Manufacturing Management Unlimited Company | Metode zdravljenja bolezni, pri katerih je aktivnost il-13 škodljiva, z uporabo protiteles anti-il-13 |
| CA3026050A1 (en) | 2016-08-05 | 2018-02-08 | Chugai Seiyaku Kabushiki Kaisha | Composition for prophylaxis or treatment of il-8 related diseases |
| WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| KR102583190B1 (ko) * | 2016-10-13 | 2023-09-26 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 항-lag-3 항체 및 조성물 |
| JOP20190093A1 (ar) * | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
| TWI857389B (zh) * | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| RU2771485C2 (ru) | 2017-02-10 | 2022-05-04 | Дженентек, Инк. | Антитела против триптазы, их композиции и применения |
| CN108456251A (zh) * | 2017-02-21 | 2018-08-28 | 上海君实生物医药科技股份有限公司 | 抗pd-l1抗体及其应用 |
| US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
| KR102751957B1 (ko) * | 2017-04-13 | 2025-01-09 | 리제너론 파마슈티칼스 인코포레이티드 | Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해 |
| CN118994394A (zh) | 2017-06-12 | 2024-11-22 | 蓝鳍生物医药公司 | 抗-il1rap抗体和抗体药物缀合物 |
| AU2018298039B2 (en) | 2017-07-06 | 2023-02-02 | Regeneron Pharmaceuticals, Inc. | Cell culture process for making a glycoprotein |
| TWI825025B (zh) * | 2017-08-31 | 2023-12-11 | 日商田邊三菱製藥股份有限公司 | 包含il-33拮抗劑的子宮內膜異位症治療劑 |
| JP7731196B2 (ja) | 2017-11-14 | 2025-08-29 | 中外製薬株式会社 | 抗C1s抗体および使用方法 |
| AU2018392334A1 (en) | 2017-12-22 | 2020-05-28 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing drug product impurities |
| SG11202005235WA (en) | 2018-01-31 | 2020-07-29 | Regeneron Pharma | System and method for characterizing size and charge variant drug product impurities |
| TWI786265B (zh) | 2018-02-02 | 2022-12-11 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| KR20230142806A (ko) | 2018-02-09 | 2023-10-11 | 제넨테크, 인크. | 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법 |
| CN111771000A (zh) | 2018-02-28 | 2020-10-13 | 瑞泽恩制药公司 | 用于鉴定病毒污染物的系统和方法 |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| WO2019182901A1 (en) | 2018-03-19 | 2019-09-26 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| IL277890B2 (en) * | 2018-04-11 | 2024-03-01 | Regeneron Pharma | Methods for quantifying il-33 |
| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| CR20210127A (es) | 2018-08-10 | 2021-04-19 | Chugai Pharmaceutical Co Ltd | Molécula de unión al antigeno anti grupo de diferenciación 137 (cd137) y su uso |
| CN112218877B (zh) | 2018-08-27 | 2025-07-25 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| US11754569B2 (en) | 2018-08-30 | 2023-09-12 | Regeneron Pharmaceuticals, Inc. | Methods for characterizing protein complexes |
| EP3857236A1 (en) | 2019-01-16 | 2021-08-04 | Regeneron Pharmaceuticals, Inc. | Methods for identifying free thiols in proteins |
| TW202519263A (zh) * | 2019-03-21 | 2025-05-16 | 美商再生元醫藥公司 | 含有抗il-33抗體之穩定調配物 |
| CA3138306A1 (en) * | 2019-05-01 | 2020-11-05 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-33 antagonist |
| KR20220007586A (ko) | 2019-05-13 | 2022-01-18 | 리제너론 파마슈티칼스 인코포레이티드 | 개선된 경쟁적 리간드 결합 검정 |
| CN114096562B (zh) | 2019-05-15 | 2025-02-21 | 中外制药株式会社 | 抗原结合分子、药物组合物和方法 |
| EP3999114A1 (en) | 2019-07-16 | 2022-05-25 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| IL317159A (en) | 2019-09-24 | 2025-01-01 | Regeneron Pharma | Systems and methods for use in chromatography and regeneration |
| WO2021064452A1 (en) | 2019-10-03 | 2021-04-08 | Dasman Diabetes Institute | Method for preventing progression to type ii diabetes |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| IL292442A (en) | 2019-11-04 | 2022-06-01 | Medimmune Ltd | Anti-il-33 therapeutic agent for the treatment of kidney disorders |
| CA3158323A1 (en) | 2019-11-04 | 2021-05-14 | Medimmune Limited | Methods of using il-33 antagonists |
| CN114760986A (zh) | 2019-11-25 | 2022-07-15 | 里珍纳龙药品有限公司 | 使用非水性乳液的持续释放调配物 |
| CN115151568A (zh) * | 2019-12-23 | 2022-10-04 | 赛诺菲生物技术公司 | 用于通过施用il-33拮抗剂和/或il-4r拮抗剂以治疗或预防过敏性哮喘的方法 |
| CN113214395A (zh) * | 2020-01-21 | 2021-08-06 | 迈威(上海)生物科技股份有限公司 | 抗st2抗体及其应用 |
| MX2022008973A (es) | 2020-01-21 | 2022-08-11 | Regeneron Pharma | Metodos de desglicosilacion para electroforesis de proteinas glicosiladas. |
| WO2021180858A1 (en) | 2020-03-13 | 2021-09-16 | Medimmune Limited | Therapeutic methods for the treatment of subjects with risk alelles in il33 |
| TW202144410A (zh) * | 2020-03-13 | 2021-12-01 | 美商建南德克公司 | 抗介白素-33抗體及其用途 |
| BR112022019937A2 (pt) | 2020-04-06 | 2022-12-13 | Medimmune Ltd | Tratamento de síndrome do desconforto respiratório agudo com antagonistas de ligação de eixo de il-33 |
| CN115398006A (zh) * | 2020-04-13 | 2022-11-25 | 麦登顾问有限责任公司 | 用于治疗covid-19的ace2靶向组合物和方法 |
| CN115551542A (zh) | 2020-05-11 | 2022-12-30 | 免疫医疗有限公司 | 抗il-33抗体的配制品 |
| KR20230010691A (ko) * | 2020-05-12 | 2023-01-19 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | St2 항원 결합 단백질 |
| KR102789102B1 (ko) * | 2020-08-18 | 2025-03-28 | 성균관대학교산학협력단 | Il-33 항체 또는 이의 항원 결합 단편 |
| WO2022047108A1 (en) | 2020-08-31 | 2022-03-03 | Regeneron Pharmaceuticals, Inc. | Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants |
| CN114249825A (zh) * | 2020-09-25 | 2022-03-29 | 三生国健药业(上海)股份有限公司 | 结合人il-33的抗体、其制备方法和用途 |
| US12239687B2 (en) | 2020-11-25 | 2025-03-04 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous membrane emulsification |
| KR20230121854A (ko) | 2020-12-17 | 2023-08-21 | 리제너론 파아마슈티컬스, 인크. | 단백질-캡슐화 마이크로겔의 제작 |
| CA3202197A1 (en) | 2021-01-20 | 2022-07-28 | Reginald Smith | Methods of improving protein titer in cell culture |
| EP4302098A1 (en) | 2021-03-03 | 2024-01-10 | Regeneron Pharmaceuticals, Inc. | Systems and methods for quantifying and modifying protein viscosity |
| EP4315344A1 (en) | 2021-03-26 | 2024-02-07 | Regeneron Pharmaceuticals, Inc. | Methods and systems for developing mixing protocols |
| CA3220848A1 (en) | 2021-06-01 | 2022-12-08 | Timothy Riehlman | Microchip capillary electrophoresis assays and reagents |
| CN113493513B (zh) * | 2021-06-30 | 2022-07-12 | 深圳大学 | 抗人il-33中和性自身抗体及其制备方法和应用 |
| CN113603775B (zh) * | 2021-09-03 | 2022-05-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素-33单克隆抗体及其应用 |
| AR127006A1 (es) | 2021-09-08 | 2023-12-06 | Regeneron Pharma | UN MÉTODO BASADO EN ESPECTROMETRÍA DE MASAS Y DE ALTO RENDIMIENTO PARA CUANTIFICAR ANTICUERPOS Y OTRAS PROTEÍNAS QUE CONTIENEN Fc |
| US20230090912A1 (en) | 2021-09-20 | 2023-03-23 | Regeneron Pharmaceuticals, Inc. | Methods of controlling antibody heterogeneity |
| IL311248A (en) | 2021-10-07 | 2024-05-01 | Regeneron Pharma | PH meter calibration and repair |
| US20230116199A1 (en) | 2021-10-07 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | Systems and methods of ph modeling and control |
| KR20240097864A (ko) | 2021-10-26 | 2024-06-27 | 리제너론 파마슈티칼스 인코포레이티드 | 상이한 온도에서 실험실 용수를 생성하고 실험실 용수를 분배하는 시스템 및 방법 |
| JP2024544885A (ja) | 2021-11-10 | 2024-12-05 | ジェネンテック, インコーポレイテッド | 抗インターロイキン-33抗体及びその使用 |
| CA3254037A1 (en) * | 2022-03-03 | 2023-09-07 | Pfizer | MULTISPECIFIC ANTIBODIES AND THEIR USES |
| EP4493921A1 (en) | 2022-03-18 | 2025-01-22 | Regeneron Pharmaceuticals, Inc. | Methods and systems for analyzing polypeptide variants |
| TW202402790A (zh) | 2022-03-25 | 2024-01-16 | 英商梅迪繆思有限公司 | 減少呼吸系統感染之方法 |
| EP4573121A1 (en) | 2022-08-19 | 2025-06-25 | MedImmune Limited | Method of selecting patients for treatment with an il-33 axis antagonist |
| KR20250124178A (ko) | 2022-12-16 | 2025-08-19 | 리제너론 파아마슈티컬스, 인크. | 크로마토그래피 칼럼의 무결성을 평가하기 위한 방법 및 시스템 |
| US20240248097A1 (en) | 2023-01-25 | 2024-07-25 | Regeneron Pharmaceuticals, Inc. | Mass spectrometry-based characterization of antibodies co-expressed in vivo |
| TW202445135A (zh) | 2023-01-25 | 2024-11-16 | 美商再生元醫藥公司 | 液態蛋白質組成物穩定性之建模方法 |
| WO2024163708A1 (en) | 2023-02-01 | 2024-08-08 | Regeneron Pharmaceuticals, Inc. | Asymmetrical flow field-flow fractionation with mass spectrometry for biomacromolecule analysis |
| US20240280551A1 (en) | 2023-02-22 | 2024-08-22 | Regeneron Pharmaceuticals, Inc. | System suitability parameters and column aging |
| AU2024265540A1 (en) | 2023-05-01 | 2025-10-30 | Regeneron Pharmaceuticals, Inc. | Multidose antibody drug products using phenol or benzyl alcohol |
| WO2025048206A1 (ko) | 2023-08-28 | 2025-03-06 | 서울대학교산학협력단 | 세포독성능을 갖는 제2형 선천성 림프구 세포, 이의 제조방법 및 용도 |
| JP7668943B2 (ja) * | 2023-08-30 | 2025-04-25 | ファイザー・インク | 多重特異性抗体およびその使用 |
| WO2025054406A1 (en) | 2023-09-08 | 2025-03-13 | Regeneron Pharmaceuticals, Inc. | Methods and systems for assessing chromatographic column integrity |
| WO2025064403A2 (en) | 2023-09-18 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for developing chromatography protocols |
| US20250109905A1 (en) | 2023-09-29 | 2025-04-03 | Regeneron Pharmaceuticals, Inc. | Lyophilization using controlled nucleation |
| US20250129117A1 (en) | 2023-10-18 | 2025-04-24 | Regeneron Pharmaceuticals, Inc. | Rapid purification of monoclonal antibody from in-process upstream cell culture material |
| US20250145662A1 (en) | 2023-11-02 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipase activity using stress |
| WO2025120567A1 (en) | 2023-12-07 | 2025-06-12 | Medimmune Limited | Method of treatment of asthma |
| WO2025137344A1 (en) | 2023-12-20 | 2025-06-26 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rβ) and related methods |
| WO2025166281A1 (en) | 2024-02-01 | 2025-08-07 | Regeneron Pharmaceuticals, Inc. | Platform for charge-detection mass spectrometry analysis of aavs |
| WO2025175164A1 (en) | 2024-02-16 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods |
| WO2025194043A1 (en) | 2024-03-15 | 2025-09-18 | Regeneron Pharmaceuticals, Inc. | Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations |
| WO2025210099A1 (en) | 2024-04-04 | 2025-10-09 | Medimmune Limited | Method of treatment and selecting a subject |
| WO2025242618A1 (en) | 2024-05-20 | 2025-11-27 | Medimmune Limited | Bronchiectasis treatment |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US550362A (en) | 1895-11-26 | crosby | ||
| US1000056A (en) | 1910-11-03 | 1911-08-08 | Carlos Van Bergh | Threshing-machine. |
| US1001164A (en) | 1911-06-09 | 1911-08-22 | Arthur W Porter | Cotton-sweep. |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| US5576191A (en) | 1994-06-17 | 1996-11-19 | Immunex Corporation | Cytokine that binds ST2 |
| US20070042978A1 (en) | 2002-12-19 | 2007-02-22 | Jean-Philippe Girard | Nf-hev compositions and methods of use |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
| US7666622B2 (en) | 2005-10-19 | 2010-02-23 | Regeneron Pharmaceuticals, Inc. | Monomeric self-associating fusion polypeptides and therapeutic uses thereof |
| US8865645B2 (en) | 2006-05-24 | 2014-10-21 | Biogen Idec Ma Inc. | Method of treating lung fibrosis using ST2 polypeptide |
| SI2041177T1 (sl) | 2006-06-02 | 2012-03-30 | Regeneron Pharma | Visoko afinitetna protitelesa za humani IL receptor |
| US7560530B1 (en) | 2006-07-20 | 2009-07-14 | Schering Corporation | IL-33 receptor |
| US8119771B2 (en) | 2007-04-26 | 2012-02-21 | The Provost, Fellow and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin | Products for altering IL-33 activity and methods thereof |
| US20100260770A1 (en) | 2007-05-18 | 2010-10-14 | Medimmune, Llc | Il-33 in inflammatory disease |
| JP2011500748A (ja) | 2007-10-26 | 2011-01-06 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 神経変性障害の治療におけるcaspaseI−依存性サイトカインの阻害剤 |
| ES2655079T3 (es) | 2009-09-10 | 2018-02-16 | Merck Sharp & Dohme Corp. | Uso de antagonistas de IL-33 para tratar enfermedades fibróticas |
| US9090694B2 (en) | 2012-04-30 | 2015-07-28 | Janssen Biotech, Inc. | ST2L antibody antagonists |
| AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| KR20150127591A (ko) | 2013-03-15 | 2015-11-17 | 리제너론 파아마슈티컬스, 인크. | Il-33 길항제 및 이의 용도 |
| RU2709722C1 (ru) | 2013-12-26 | 2019-12-19 | Мицубиси Танабе Фарма Корпорейшн | Нейтрализующие моноклональные человеческие антитела против интерлейкина-33 |
| US10059764B2 (en) | 2014-01-10 | 2018-08-28 | Anaptysbio, Inc. | Antibodies directed against interleukin-33 (IL-33) and methods of making and using |
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