ES2975215T3 - Administración de agentes terapéuticos mediante una proteína de unión a colágeno - Google Patents

Administración de agentes terapéuticos mediante una proteína de unión a colágeno Download PDF

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Publication number
ES2975215T3
ES2975215T3 ES20184066T ES20184066T ES2975215T3 ES 2975215 T3 ES2975215 T3 ES 2975215T3 ES 20184066 T ES20184066 T ES 20184066T ES 20184066 T ES20184066 T ES 20184066T ES 2975215 T3 ES2975215 T3 ES 2975215T3
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Prior art keywords
pth
collagen
cbd
seq
residues
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ES20184066T
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English (en)
Spanish (es)
Inventor
Joshua Sakon
Sagaya Theresa Philominathan
Ranjitha Katikaneni
Osama Matsushita
Tulasi Ponnapakkam
Takaki Koide
Robert Gensure
Nozomu Nishi
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Kitasato University
Kagawa University
Montefiore Medical Center
University of Arkansas at Fayetteville
University of Arkansas at Little Rock
Original Assignee
Kitasato University
Kagawa University
Montefiore Medical Center
University of Arkansas at Fayetteville
University of Arkansas at Little Rock
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2583002T3 (es) 2007-04-09 2016-09-16 The Board Of Trustees Of The University Of Arkansas Proteínas de fusión de un dominio de enlazamiento a colágeno y hormona paratiroidea
WO2013120060A1 (en) 2012-02-09 2013-08-15 The Board Of Trustees Of The University Of Arkansas Delivery of therapeutic agents by a collagen binding protein
US9579273B2 (en) 2011-12-14 2017-02-28 The Kitasato Institute Delivery of therapeutic agents by a collagen binding protein
US11624060B2 (en) * 2017-02-10 2023-04-11 The Board Of Trustees Of The University Of Arkansas Collagen-binding agent compositions and methods of using the same
GB201706781D0 (en) 2017-04-28 2017-06-14 Univ Sheffield Parathyroid hormone fusion polypeptide
KR101964376B1 (ko) * 2017-09-29 2019-04-01 주식회사 나이벡 부갑상선호르몬(parathyroid hormone, PTH)에 골조직 선택성 펩타이드가 결합되어 있는 융합 펩타이드를 포함하는 약학 조성물 및 생체재료
JP7045166B2 (ja) * 2017-11-07 2022-03-31 株式会社ニッピ コラーゲン結合材、その製造方法、ドラッグデリバリーシステム、および担持体
JP2021516966A (ja) * 2018-03-09 2021-07-15 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 組織への生物学的薬物の送達
US20220363778A1 (en) * 2019-08-28 2022-11-17 The Research Foundation For The State University Of New York Targeted delivery of tumor matrix modifying enzymes
WO2022050176A1 (ja) * 2020-09-02 2022-03-10 コラジェン・ファーマ株式会社 ペプチドを含む組成物及びその用途
US12403179B2 (en) 2021-02-18 2025-09-02 The Board Of Trustees Of The University Of Arkansas Release of growth factors at wound healing stages
EP4543480A2 (en) * 2022-06-27 2025-04-30 Sustain Holdings, LLC Collagen peptide-based medicament compositions and uses thereof

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8516421D0 (en) 1985-06-28 1985-07-31 Biotechnology Interface Ltd Fibronectins
JP2950520B2 (ja) 1993-04-02 1999-09-20 アンティキャンサー インコーポレーテド 毛胞に有益な配合物を送達する方法
AU3819497A (en) 1996-07-31 1998-02-20 General Hospital Corporation, The Novel parathyroid hormone-related peptide analogs
US20100267012A1 (en) * 1997-11-04 2010-10-21 Bergeron Michel G Highly conserved genes and their use to generate probes and primers for detection of microorganisms
US6387663B1 (en) 1998-07-31 2002-05-14 University Of Southern California Targeting pharmaceutical agents to injured tissues
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
US20020102709A1 (en) 1999-02-19 2002-08-01 Tetsuya Ishikawa Collagen-binding physiologically active polypeptide
CN1347456A (zh) 1999-02-19 2002-05-01 泰尔茂株式会社 胶原结合生理活性多肽
US6908994B1 (en) 1999-05-10 2005-06-21 The Texas A&M University System Collagen-binding proteins from enterococcal bacteria
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050124537A1 (en) 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
EP1314780A4 (en) 2000-08-15 2004-07-28 Terumo Corp Collagen-binding hybrid polypeptides
JP2002058485A (ja) * 2000-08-16 2002-02-26 Terumo Corp コラーゲン結合性を有する骨形成促進融合蛋白質
CA2470419A1 (en) 2001-12-18 2003-06-26 Eidgenossisch Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
CA2492295C (en) 2002-07-25 2014-01-28 The General Hospital Corporation Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion
CA2516113A1 (en) 2003-02-13 2004-08-26 Synthes (U.S.A.) Injectable bone-replacement mixture
US20040220094A1 (en) 2003-05-01 2004-11-04 Skinner Keith K. Inverse agonist and agonist peptides that stimulate/inhibit hair growth
EP1680073B1 (en) 2003-10-21 2013-01-02 IGF Oncology, LLC Compounds and method for treating cancer
WO2005046798A1 (en) 2003-11-12 2005-05-26 Nps Allelix Corp. Treatment of bone loss utilizing full length parathyroid hormone
EP1557176A1 (en) 2004-01-26 2005-07-27 Ferring B.V. Treatment of bone metastases by means of PTH receptor agonists
US8030448B2 (en) * 2004-02-16 2011-10-04 Techno Network Shikoku Co., Ltd. Polypeptide having collagen-like structure
WO2005082941A1 (en) 2004-02-27 2005-09-09 The University Of Western Ontario Bone sialoprotein collagen-binding peptides
PL1759001T3 (pl) 2004-04-21 2011-09-30 Alexion Pharma Inc Koniugaty dostarczane do kości i sposób ich zastosowania do nakierowywania białek do kości
WO2006047214A2 (en) 2004-10-21 2006-05-04 Igf Oncology, Llc Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
ATE514712T1 (de) * 2005-12-26 2011-07-15 Yantai Zhenghai Bio Technology Co Ltd Aktivierte collagen-gerüstmaterialien und ihre speziellen kondensierten aktiven restorationsfaktoren
JP5645408B2 (ja) * 2006-11-16 2014-12-24 カイ ファーマシューティカルズ インコーポレーティッド 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
WO2008101406A1 (en) * 2007-02-14 2008-08-28 Yolare Dermaceuticals, Llc Modified mutant collagenase and it's use in fat melting and in scar reduction
WO2008123166A1 (en) * 2007-03-20 2008-10-16 Nsk-Warner K.K. Roller-type one-way clutch
ES2583002T3 (es) * 2007-04-09 2016-09-16 The Board Of Trustees Of The University Of Arkansas Proteínas de fusión de un dominio de enlazamiento a colágeno y hormona paratiroidea
US8486422B2 (en) * 2007-07-26 2013-07-16 Allergan, Inc. Methods of activating clostridial toxins
US20100159564A1 (en) * 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
JP5400336B2 (ja) 2008-08-04 2014-01-29 トヨタ紡織株式会社 表皮材の成形装置
US10545149B2 (en) 2008-10-06 2020-01-28 Morehouse School Of Medicine Detection of HIV-related proteins in urine
JP2010172247A (ja) 2009-01-29 2010-08-12 Kitasato Institute 積層型高密度培養人工組織の製造方法及び積層型高密度培養人工組織
WO2011060431A2 (en) * 2009-11-16 2011-05-19 University Of Maryland Baltimore Multivalent live vector vaccine against clostridium difficile-associated disease
WO2011142425A1 (ja) 2010-05-12 2011-11-17 国立大学法人香川大学 上皮層含有組織の再生材および再生評価方法
ES2385239B1 (es) * 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
ES2726530T3 (es) * 2011-03-16 2019-10-07 Univ Tohoku Sonda para analizar tejido biológico y método para utilizar la misma
WO2012157339A1 (ja) 2011-05-13 2012-11-22 学校法人北里研究所 成長因子アンカーリング型骨移植材料、成長因子アンカーリング型骨移植材料の製造方法、成長因子アンカーリング型骨移植材料製造用キット、および骨形成方法
WO2013120060A1 (en) * 2012-02-09 2013-08-15 The Board Of Trustees Of The University Of Arkansas Delivery of therapeutic agents by a collagen binding protein
US9579273B2 (en) * 2011-12-14 2017-02-28 The Kitasato Institute Delivery of therapeutic agents by a collagen binding protein
EP4772625A2 (en) * 2012-01-12 2026-07-08 Endo Biologics Limited Clostridium histolyticum enzyme
WO2013120030A1 (en) * 2012-02-08 2013-08-15 Shining Golden Yida Welding & Cutting Machinery Manufacture Ltd. Rotary vane air motor with improved vanes and other improvements
JP6403062B2 (ja) * 2012-12-21 2018-10-10 国立大学法人徳島大学 組織修復活性組成物及びその利用
SG11201602012RA (en) * 2013-09-25 2016-04-28 Pronutria Inc Compositions and formulations for maintaining and increasing muscle mass, strength, and performance and methods of production and use thereof
US9539363B2 (en) * 2014-04-24 2017-01-10 Warsaw Orthopedic, Inc. Collagen matrix
US20180140742A1 (en) * 2014-10-16 2018-05-24 School Juridical Person Kitasato Institute Graft material for nerve regeneration, method for producing graft material for nerve regeneration, and kit for producing graft material for nerve regeneration
EP3112474A1 (en) * 2015-06-29 2017-01-04 Evonik Degussa GmbH Method of detecting avian necrotic enteritis
US10513696B2 (en) * 2016-05-24 2019-12-24 Hamzeh Alipour Lucilia sericata collagenase
HUE063235T2 (hu) * 2016-09-29 2024-01-28 Ascendis Pharma Bone Diseases As Adagolási rendszer szabályozott leadású PTH vegyülethez
US11624060B2 (en) * 2017-02-10 2023-04-11 The Board Of Trustees Of The University Of Arkansas Collagen-binding agent compositions and methods of using the same
WO2019113123A1 (en) * 2017-12-04 2019-06-13 Precithera, Inc. TGF-ß RECEPTOR FUSION PROTEINS AND OTHER TGF-ß ANTAGONISTS FOR REDUCING TGF-ß SIGNALING
WO2019147735A1 (en) * 2018-01-23 2019-08-01 New York University Antibodies specific to delta 1 chain of t cell receptor
JP2021516966A (ja) * 2018-03-09 2021-07-15 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 組織への生物学的薬物の送達
EP3836923B1 (en) * 2018-08-14 2024-10-16 OssiFi Therapeutics LLC Pyrrolo - dipyridine compounds for the treatment of bone loss

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