ES2911075T3 - Constructos de administración para transcitosis y métodos relacionados - Google Patents
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (5)
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| US201862756889P | 2018-11-07 | 2018-11-07 | |
| PCT/US2019/021474 WO2019173787A1 (en) | 2018-03-08 | 2019-03-08 | Toxin-derived delivery constructs for oral delivery |
| US201962888238P | 2019-08-16 | 2019-08-16 | |
| US201962888133P | 2019-08-16 | 2019-08-16 | |
| PCT/US2019/050708 WO2020096695A1 (en) | 2018-11-07 | 2019-09-11 | Cholix-derived carriers for oral delivery of heterologous payload |
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| SG (1) | SG11202104721RA (zh) |
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| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| PL3762009T3 (pl) | 2018-03-08 | 2022-09-12 | Applied Molecular Transport Inc. | Pochodzące z toksyny konstrukty dostarczające do dostarczania doustnego |
| PL3650037T3 (pl) | 2018-11-07 | 2022-06-06 | Applied Molecular Transport Inc. | Konstrukty dostarczające do transcytozy i powiązane z nimi sposoby |
| JP2022512976A (ja) | 2018-11-07 | 2022-02-07 | アプライド モレキュラー トランスポート インコーポレイテッド | 異種ペイロードの経口送達のためのコリックス由来担体 |
| WO2021034727A1 (en) | 2019-08-16 | 2021-02-25 | Applied Molecular Transport Inc. | Compositions, formulations, and interleukin production and purification |
| JP2023530095A (ja) * | 2020-06-09 | 2023-07-13 | アイコサバックス， インコーポレイテッド | ウイルス様粒子を作製する方法 |
| CN117603361A (zh) * | 2022-08-22 | 2024-02-27 | 复旦大学附属儿科医院 | 包含angptl3单抗的融合蛋白 |
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| US5668255A (en) | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
| DE3680924D1 (de) | 1985-01-14 | 1991-09-26 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
| US6051405A (en) | 1986-09-24 | 2000-04-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Constructs encoding recombinant antibody-toxin fusion proteins |
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| ES2332261T3 (es) | 2000-11-27 | 2010-02-01 | Powderject Vaccines, Inc. | Adyuvantes de acidos nucleicos. |
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| US20050074462A1 (en) | 2001-05-23 | 2005-04-07 | Duotol Ab | Supression of allergic reactions by transdermal administration of allergens conjugated to cholera toxin or fragments thereof |
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| EP1522585A1 (en) | 2003-10-09 | 2005-04-13 | Plant Research International B.V. | Chimeric carrier molecules for the production of mucosal vaccines |
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| WO2008011157A2 (en) * | 2006-07-20 | 2008-01-24 | The General Hospital Corporation | Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting |
| US20090092660A1 (en) | 2006-08-09 | 2009-04-09 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of particles |
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2019
- 2019-11-07 PL PL19207825T patent/PL3650037T3/pl unknown
- 2019-11-07 KR KR1020217017210A patent/KR20210110294A/ko unknown
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- 2019-11-07 ES ES19207825T patent/ES2911075T3/es active Active
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- 2019-11-07 MX MX2021005346A patent/MX2021005346A/es unknown
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- 2019-11-07 JP JP2021525169A patent/JP2022506990A/ja active Pending
- 2019-11-07 SG SG11202104721RA patent/SG11202104721RA/en unknown
- 2019-11-07 CN CN201980088287.9A patent/CN113423722A/zh active Pending
- 2019-11-07 EA EA202191280A patent/EA202191280A1/ru unknown
- 2019-11-07 TW TW108140533A patent/TW202031678A/zh unknown
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| US20210338828A1 (en) | 2021-11-04 |
| AU2019377117A1 (en) | 2021-06-10 |
| CO2021007402A2 (es) | 2021-09-30 |
| PT3650037T (pt) | 2022-06-27 |
| CA3119060A1 (en) | 2020-05-14 |
| BR112021009003A2 (pt) | 2021-08-17 |
| CL2021001209A1 (es) | 2021-11-19 |
| EP4083058A2 (en) | 2022-11-02 |
| EP4083058A3 (en) | 2023-01-11 |
| IL282987B (en) | 2022-10-01 |
| PL3650037T3 (pl) | 2022-06-06 |
| DK3650037T3 (da) | 2022-05-02 |
| TW202031678A (zh) | 2020-09-01 |
| WO2020097394A1 (en) | 2020-05-14 |
| SG11202104721RA (en) | 2021-06-29 |
| EP3650037B1 (en) | 2022-03-02 |
| CN113423722A (zh) | 2021-09-21 |
| US20200306383A1 (en) | 2020-10-01 |
| IL282987A (en) | 2021-06-30 |
| JP2022506990A (ja) | 2022-01-17 |
| EP3650037A1 (en) | 2020-05-13 |
| MX2021005346A (es) | 2021-10-13 |
| IL282987B2 (en) | 2023-02-01 |
| EA202191280A1 (ru) | 2021-12-27 |
| KR20210110294A (ko) | 2021-09-07 |
| US11027020B2 (en) | 2021-06-08 |
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