ES2910361T3 - Composiciones que comprenden desmopresina en combinación con un agonista del receptor adrenérgico beta-3 - Google Patents
Composiciones que comprenden desmopresina en combinación con un agonista del receptor adrenérgico beta-3 Download PDFInfo
- Publication number
- ES2910361T3 ES2910361T3 ES14748451T ES14748451T ES2910361T3 ES 2910361 T3 ES2910361 T3 ES 2910361T3 ES 14748451 T ES14748451 T ES 14748451T ES 14748451 T ES14748451 T ES 14748451T ES 2910361 T3 ES2910361 T3 ES 2910361T3
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- Prior art keywords
- desmopressin
- beta
- adrenergic receptor
- receptor agonist
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A61K38/095—Oxytocins; Vasopressins; Related peptides
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
| CN108295241A (zh) * | 2009-06-18 | 2018-07-20 | 宁静制药公司 | 安全的去氨加压素给药 |
| US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
| KR20240015735A (ko) | 2013-07-23 | 2024-02-05 | 세레니티 파마슈티컬즈 엘엘씨 | 베타-3-아드레날린 수용체 작용제와 함께 데스모프레신을 포함하는 방법 및 조성물 |
| EP3024473A1 (en) | 2013-07-23 | 2016-06-01 | Allergan, Inc. | Methods and compositions comprising desmopressin in combination with a 5-alpha reductase inhibitor |
| DK3220942T3 (da) | 2014-11-20 | 2022-07-18 | Serenity Pharmaceuticals Llc | Sammensætninger omfattende lav dosis af desmopressin i kombination med en alpha-adrenerg receptorantagonist |
| KR20170086659A (ko) | 2014-12-03 | 2017-07-26 | 벨리셉트 테라퓨틱스, 인크. | 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법 |
| US20170348263A1 (en) * | 2016-06-03 | 2017-12-07 | Velicept Therapeutics, Inc. | Compositions and methods of using modified release solabegron for lower urinary tract symptoms |
| KR101877834B1 (ko) * | 2017-04-27 | 2018-07-12 | 주식회사 다산제약 | 미라베그론의 신규한 염 및 이의 제조방법 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH495957A (de) | 1966-09-15 | 1970-09-15 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids |
| US4316893A (en) | 1975-06-19 | 1982-02-23 | Nelson Research & Development Co. | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
| US4405616A (en) | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4557934A (en) | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4783450A (en) | 1987-04-13 | 1988-11-08 | Warner-Lambert Company | Use of commercial lecithin as skin penetration enhancer |
| IL101243A (en) | 1991-03-20 | 1999-12-22 | Merck & Co Inc | Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history |
| US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
| EP1035833B1 (en) | 1997-12-02 | 2005-08-31 | Archimedes Development Limited | Compositions for nasal administration |
| US7335186B2 (en) | 1998-03-13 | 2008-02-26 | Alexander George Brian O'Neil | Patient controlled drug delivery device |
| US6558695B2 (en) | 1999-12-16 | 2003-05-06 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers |
| ES2574917T3 (es) | 2000-11-30 | 2016-06-23 | Valeritas, Inc. | Sistemas y procedimientos de suministro y medición de fluido |
| US7244703B2 (en) | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| AU2003284700B2 (en) * | 2002-11-07 | 2009-05-28 | Astellas Pharma Inc. | Remedy for overactive bladder comprising acetic acid anlide derivatives as the active ingredient |
| WO2005046707A1 (en) | 2003-11-10 | 2005-05-26 | Fein Seymour H | Pharmaceutical compositions including low dosages of desmopressin |
| JP2007513199A (ja) | 2003-12-08 | 2007-05-24 | ベントレー ファーマスーティカルス，インコーポレイテッド | インスリン治療のための薬学的組成物及び方法 |
| DE102005016981A1 (de) | 2005-04-13 | 2006-10-19 | Bayer Healthcare Ag | Kombination zur Therapie bei benigner Prostatahyperplasie |
| CA2633570A1 (en) | 2005-12-21 | 2007-06-28 | Pfizer Products Inc. | Pharmaceutical combination of a pde-5 inhibitor and a 5-alpha reductase inhibitor |
| JPWO2007083640A1 (ja) * | 2006-01-18 | 2009-06-11 | 杏林製薬株式会社 | 頻尿及び尿失禁の予防又は治療剤 |
| RU2472539C2 (ru) | 2007-08-06 | 2013-01-20 | Аллерган, Инк. | Способы и устройства для доставки препарата десмопрессина |
| CN101648017A (zh) | 2008-08-12 | 2010-02-17 | 许洁 | 用于治疗泌尿生殖系统及下尿路疾病的联合药物组合物 |
| US20110144055A1 (en) | 2008-09-04 | 2011-06-16 | Rozmanith Anthony I | Health Care |
| EA201791732A1 (ru) * | 2008-12-22 | 2018-03-30 | Серенити Фармасьютикалз, Элэлси | Безопасное введение десмопрессина |
| WO2010075327A1 (en) | 2008-12-22 | 2010-07-01 | Serenity Pharmaceuticals Corporation | Desmopressin composition |
| CN108295241A (zh) | 2009-06-18 | 2018-07-20 | 宁静制药公司 | 安全的去氨加压素给药 |
| BR112012007829A2 (pt) * | 2009-10-07 | 2015-09-22 | Merck Sharp & Dohme | método para tratar bexiga hiperativa, e, composição farmacêutica. |
| US9119878B2 (en) | 2010-07-08 | 2015-09-01 | Wellesley Pharmaceuticals, Llc | Extended-release formulation for reducing the frequency of urination and method of use thereof |
| US9522129B2 (en) * | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
| WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
| RU2669565C2 (ru) | 2012-03-19 | 2018-10-12 | УЭЛЛСЛИ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Препарат длительного высвобождения для снижения частоты мочеиспускания и способ его применения |
| TW201422254A (zh) | 2012-11-21 | 2014-06-16 | Ferring Bv | 用於速釋及延釋的組成物 |
| GB201312155D0 (en) | 2013-07-05 | 2013-08-21 | Ucl Business Plc | Therapeutic invention |
| EP3024473A1 (en) | 2013-07-23 | 2016-06-01 | Allergan, Inc. | Methods and compositions comprising desmopressin in combination with a 5-alpha reductase inhibitor |
| KR20240015735A (ko) * | 2013-07-23 | 2024-02-05 | 세레니티 파마슈티컬즈 엘엘씨 | 베타-3-아드레날린 수용체 작용제와 함께 데스모프레신을 포함하는 방법 및 조성물 |
| CA2923270A1 (en) | 2013-09-03 | 2015-03-12 | Shin Nippon Biomedical Laboratories Ltd. (Snbl) | Intranasal formulation for the treatment of cardiopulmonary resuscitation (cpr), cardiac life support (cls), anaphylaxis and/or anaphylactoid reactions |
| DK3220942T3 (da) | 2014-11-20 | 2022-07-18 | Serenity Pharmaceuticals Llc | Sammensætninger omfattende lav dosis af desmopressin i kombination med en alpha-adrenerg receptorantagonist |
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- 2014-07-23 WO PCT/US2014/047899 patent/WO2015013454A1/en not_active Ceased
- 2014-07-23 US US14/338,554 patent/US9814753B2/en not_active Expired - Fee Related
- 2014-07-23 KR KR1020217025792A patent/KR20210103589A/ko not_active Ceased
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| EP3024474B1 (en) | 2022-01-05 |
| US20180289769A1 (en) | 2018-10-11 |
| US20150031613A1 (en) | 2015-01-29 |
| DK3024474T3 (da) | 2022-03-28 |
| CA2919198A1 (en) | 2015-01-29 |
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| JP2016525548A (ja) | 2016-08-25 |
| JP2020109122A (ja) | 2020-07-16 |
| KR20210103589A (ko) | 2021-08-23 |
| CN105579057A (zh) | 2016-05-11 |
| KR20240015735A (ko) | 2024-02-05 |
| JP7219736B2 (ja) | 2023-02-08 |
| US10568927B2 (en) | 2020-02-25 |
| US9814753B2 (en) | 2017-11-14 |
| WO2015013454A1 (en) | 2015-01-29 |
| EP3024474A1 (en) | 2016-06-01 |
| MX2016001030A (es) | 2016-10-07 |
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