ES2892342T3 - Sistema óptico para detectar la luz de reacciones en cadena de la polimerasa - Google Patents
Sistema óptico para detectar la luz de reacciones en cadena de la polimerasa Download PDFInfo
- Publication number
- ES2892342T3 ES2892342T3 ES13151696T ES13151696T ES2892342T3 ES 2892342 T3 ES2892342 T3 ES 2892342T3 ES 13151696 T ES13151696 T ES 13151696T ES 13151696 T ES13151696 T ES 13151696T ES 2892342 T3 ES2892342 T3 ES 2892342T3
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/08—Optical fibres; light guides
- G01N2201/0826—Fibre array at source, distributing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/08—Optical fibres; light guides
- G01N2201/0833—Fibre array at detector, resolving
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14339109P | 2009-01-08 | 2009-01-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2892342T3 true ES2892342T3 (es) | 2022-02-03 |
Family
ID=42316903
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13151696T Active ES2892342T3 (es) | 2009-01-08 | 2010-01-08 | Sistema óptico para detectar la luz de reacciones en cadena de la polimerasa |
| ES10726151T Active ES2875831T3 (es) | 2009-01-08 | 2010-01-08 | Sistema óptico para reacciones químicas y/o bioquímicas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10726151T Active ES2875831T3 (es) | 2009-01-08 | 2010-01-08 | Sistema óptico para reacciones químicas y/o bioquímicas |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10029227B2 (https=) |
| EP (3) | EP2584344B1 (https=) |
| JP (2) | JP5864262B2 (https=) |
| CN (1) | CN102341694B (https=) |
| CA (1) | CA2749247A1 (https=) |
| DE (1) | DE202010018011U1 (https=) |
| DK (1) | DK2584344T3 (https=) |
| ES (2) | ES2892342T3 (https=) |
| WO (1) | WO2010079338A2 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2749247A1 (en) | 2009-01-08 | 2010-07-15 | It-Is International Ltd. | Optical system for chemical and/or biochemical reactions |
| DE102010010741A1 (de) * | 2010-03-09 | 2011-09-15 | Beckman Coulter, Inc. | Lichtleitervorrichtung zum Abstrahlen und Empfangen von Licht, System, Verfahren und Computerprogrammprodukt |
| GB201005704D0 (en) * | 2010-04-06 | 2010-05-19 | It Is Internat Ltd | Improvements in systems for chemical and/or biochemical reactions |
| EP3151015A1 (en) * | 2010-11-15 | 2017-04-05 | F. Hoffmann-La Roche AG | Instrument and method for the automated thermal treatment of liquid samples |
| CN102645276A (zh) * | 2011-02-16 | 2012-08-22 | 台湾超微光学股份有限公司 | 光谱感测设备、系统及方法 |
| EP2525211B1 (en) | 2011-05-16 | 2018-01-03 | F. Hoffmann-La Roche AG | Instrument and method for detecting analytes |
| JP5883314B2 (ja) * | 2011-09-02 | 2016-03-15 | 日本インスツルメンツ株式会社 | 還元気化水銀測定装置 |
| EP2581728B1 (en) * | 2011-10-10 | 2013-09-18 | CYCLERtest B.V. | Calibration device for a thermal cycler |
| US9551030B2 (en) * | 2012-06-17 | 2017-01-24 | Pacific Biosciences Of California, Inc. | Filter architecture for analytical devices |
| TWI458828B (zh) * | 2012-07-18 | 2014-11-01 | Univ Nat Pingtung Sci & Tech | Droplet type high throughput thermal cycling system |
| CA2879638A1 (en) * | 2012-08-10 | 2014-02-13 | Streck, Inc. | Real-time optical system for polymerase chain reaction |
| US10101274B2 (en) | 2012-12-05 | 2018-10-16 | Genepoc Inc. | Optical interrogation device |
| EP4513175A3 (en) | 2013-02-22 | 2025-05-07 | Life Technologies Corporation | Optical systems and methods for biological analysis |
| US10006861B2 (en) | 2013-06-28 | 2018-06-26 | Streck, Inc. | Devices for real-time polymerase chain reaction |
| WO2015057165A1 (en) * | 2013-10-14 | 2015-04-23 | Agency For Science, Technology And Research | Non-motorized optical multiplexing for the simultaneous detection of dna target amplicons in a polymerase chain reaction solution |
| GB2591198B (en) | 2014-04-04 | 2021-10-27 | It Is Int Ltd | Biochemical reaction system |
| GB2594163B (en) * | 2014-04-04 | 2022-01-12 | It Is International Ltd | Biochemical reaction system |
| CN105092544A (zh) * | 2014-05-12 | 2015-11-25 | 绍兴安尼特微电子科技有限公司 | 一种荧光定量pcr检测仪光学激发和检测系统 |
| WO2016125236A1 (ja) | 2015-02-02 | 2016-08-11 | 株式会社日立ハイテクノロジーズ | 多色蛍光分析装置 |
| DE102015003019A1 (de) * | 2015-03-06 | 2016-09-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren und Vorrichtung zur optischen Detektion einer Bewegung in einer biologischen Probe mit räumlicher Ausdehnung |
| DE102016200271A1 (de) | 2016-01-13 | 2017-07-13 | Institut Dr. Foerster Gmbh & Co. Kg | Vorrichtung zur Erzeugung und Messung einer Emission |
| US20170266668A1 (en) * | 2016-03-15 | 2017-09-21 | Abbott Laboratories | Nucleic Acid Amplification and Detection Devices, Systems and Methods |
| FR3051251B1 (fr) * | 2016-05-10 | 2018-06-15 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Systeme d'observation d'une plaque a puits |
| SE539770C2 (en) * | 2016-06-10 | 2017-11-21 | Bomill Ab | A detector system comprising a plurality of light guides and a spectrometer comprising the detector system |
| CH712735A1 (de) * | 2016-07-22 | 2018-01-31 | Tecan Trading Ag | Pipettiervorrichtung mit einem Flüssigkeitsvolumensensor und Flüssigkeitsbearbeitungssystem. |
| JP6747192B2 (ja) * | 2016-09-07 | 2020-08-26 | 株式会社島津製作所 | 遺伝子増幅装置 |
| CN106770086A (zh) * | 2016-11-24 | 2017-05-31 | 北京旌准医疗科技有限公司 | 一种实时荧光定量pcr仪的荧光检测方法及系统 |
| US20180156717A1 (en) * | 2016-12-05 | 2018-06-07 | Bill & Melinda Gates Foundation | Multi-test assay systems and methods of using the same |
| DE102016225817B4 (de) * | 2016-12-21 | 2019-07-04 | Bayer Pharma Aktiengesellschaft | Verfahren und System für Messungen im Hochdurchsatz-Screening mit hoher Zeitauflösung |
| JP6904131B2 (ja) * | 2017-07-21 | 2021-07-14 | 株式会社島津製作所 | 遺伝子測定装置 |
| CN107741400B (zh) * | 2017-11-15 | 2024-01-26 | 苏州雅睿生物技术股份有限公司 | 一种ivd体外检测设备的样本检测系统 |
| CN108007564B (zh) * | 2017-11-17 | 2018-10-26 | 浙江大学 | 一种大动态范围光电信号测量系统及测量方法 |
| DE102017223851B4 (de) * | 2017-12-28 | 2020-08-06 | Biochip Systems GmbH | Sensoranordnung zur Detektion wenigstens einer stofflichen Eigenschaft einer Probe sowie Mikrotiter-Platte mit einer Vielzahl von Sensoranordnungen |
| CN108181239B (zh) * | 2018-02-07 | 2023-09-12 | 张哲夫 | 一种多通道荧光定量pcr仪的光学系统 |
| DE102018202588A1 (de) * | 2018-02-21 | 2019-08-22 | Robert Bosch Gmbh | Optische Sensorvorrichtung sowie ein Verfahren zur Herstellung einer optischen Sensorvorrichtung |
| SG10201801853WA (en) * | 2018-03-02 | 2019-10-30 | Delta Electronics Int’L Singapore Pte Ltd | Portable multi-color fluorescence detection device |
| US10935492B2 (en) * | 2018-04-13 | 2021-03-02 | Applied Materials, Inc. | Metrology for OLED manufacturing using photoluminescence spectroscopy |
| DE102018111033A1 (de) * | 2018-05-08 | 2019-11-14 | Byonoy Gmbh | Transmissionsvorrichtung zur Untersuchung von Proben in Kavitäten einer Mikrotiterplatte und Verfahren zum Untersuchen von Proben in Kavitäten einer Mikrotiterplatte mittels Transmission |
| JP6688342B2 (ja) | 2018-07-06 | 2020-04-28 | 日本板硝子株式会社 | 反応処理装置 |
| EP3820610A1 (en) | 2018-07-12 | 2021-05-19 | Luminex Corporation | Systems and methods for performing variable sample preparation and analysis processes |
| DE102018212489A1 (de) * | 2018-07-26 | 2020-01-30 | Implen GmbH | Vorrichtung für eine lichtspektroskopische Analyse |
| TWI674413B (zh) * | 2018-10-31 | 2019-10-11 | 致茂電子股份有限公司 | 探針對準設備 |
| JP7497186B2 (ja) * | 2019-09-03 | 2024-06-10 | Ｔｉａｎｍａ Ｊａｐａｎ株式会社 | 蛍光偏光測定システム |
| CN110967324A (zh) * | 2019-10-14 | 2020-04-07 | 广东省测试分析研究所（中国广州分析测试中心） | 一种多通道实时荧光检测仪的光学检测装置 |
| WO2021074970A1 (ja) * | 2019-10-15 | 2021-04-22 | 株式会社日立ハイテク | 核酸試料処理装置および核酸試料処理方法 |
| DE102019128546A1 (de) * | 2019-10-22 | 2021-04-22 | Byonoy Gmbh | Transmissionsvorrichtung zur Untersuchung von Proben in Kavitäten einer Mikrotiterplatte und Verfahren zum Untersuchen von Proben in Kavitäten einer Mikrotiterplatte mittels Transmission |
| JP7233385B2 (ja) * | 2020-01-20 | 2023-03-06 | 日本板硝子株式会社 | 反応処理装置 |
| EP4121745A4 (en) | 2020-03-16 | 2023-09-06 | Siemens Healthcare Diagnostics, Inc. | OPTICAL DISCRIMINATION APPARATUS AND METHODS SUITABLE FOR MONITORING REACTIONS |
| DE102020108957B4 (de) | 2020-03-31 | 2021-10-07 | Otto-Von-Guericke-Universität Magdeburg | Vorrichtung, Verfahren und Computerprogramm zur Fluoreszenzmessung |
| JP2023525904A (ja) * | 2020-05-19 | 2023-06-19 | モラーレイ リサーチ インク． | ランダムアクセスアルタイム定量的ポリメラーゼ連鎖反応（ｑＰＣＲ）リアクターシステム |
| BE1028508B1 (fr) * | 2020-07-20 | 2022-02-15 | Pharma Flex S A | Sonde pour analyse spectroscopique d'objets individuels en défilement |
| US20240019356A1 (en) * | 2020-12-09 | 2024-01-18 | Ams-Osram Ag | An optical absorbance spectrometer, optical device and method of optical absorbance spectrometry |
| CN112945869B (zh) * | 2021-02-01 | 2021-11-16 | 杭州赛基生物科技有限公司 | 智慧医院液体试样检测试剂盒用膜载体、试剂盒及膜载体制造方法 |
| JP7628181B2 (ja) * | 2021-06-30 | 2025-02-07 | 株式会社日立ハイテク | キャピラリ電気泳動装置 |
| EP4363832A4 (en) | 2021-06-30 | 2025-05-07 | Q-State Biosciences, Inc. | MULTIPLEX OPTICAL STIMULUS AND READOUT PROCESS |
| CN113607676B (zh) * | 2021-08-04 | 2022-04-05 | 淮北师范大学 | 基于异形比色皿和近红外图像的牛奶成分快速检测方法 |
| CN114480111A (zh) * | 2022-02-15 | 2022-05-13 | 深圳阿斯克医疗有限公司 | 一种实时荧光定量pcr仪 |
| CN115343350B (zh) * | 2022-08-30 | 2025-06-17 | 南京国科精准医学科技有限公司 | 一种电化学发光检测装置以及使用方法 |
| DE102023104746A1 (de) * | 2023-02-27 | 2024-08-29 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Detektorvorrichtung zum erfassen von fluoreszenzlicht |
| DE102023204533B4 (de) * | 2023-05-15 | 2025-03-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Verfahren für die Durchführung von biochemischen Untersuchungen an Proben |
| DE102024201487A1 (de) * | 2024-02-19 | 2025-08-21 | Robert Bosch Gesellschaft mit beschränkter Haftung | Optische Einheit zur Fluoreszenzlichtbilddarstellung, insbesondere für eine Analyseeinrichtung zum Nachweis von Krankheitserregern und Verfahren zum Herstellen einer optischen Einheit |
| WO2025224859A1 (ja) * | 2024-04-24 | 2025-10-30 | 株式会社日立ハイテク | 遺伝子検査装置 |
| DE102024135031B3 (de) * | 2024-11-27 | 2026-01-29 | opto biolabs GmbH | Vorrichtung zur Bestrahlung einer Probe und Verwendung einer Vorrichtung zur Bestrahlung einer Probe |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US615674A (en) * | 1898-12-13 | Richard beasley browne | ||
| JPH0619321B2 (ja) * | 1986-06-27 | 1994-03-16 | 東ソー株式会社 | マイクロプレ−ト用吸光度測定装置 |
| DE3785932T2 (de) | 1986-11-26 | 1993-11-25 | Richard Ansorge | Optische abbildungsvorrichtung mit hoher auflösung. |
| JPS63298137A (ja) | 1987-05-29 | 1988-12-05 | Soken:Kk | イメ−ジファイバを用いた検体分析装置 |
| KR100236506B1 (ko) | 1990-11-29 | 2000-01-15 | 퍼킨-엘머시터스인스트루먼츠 | 폴리머라제 연쇄 반응 수행 장치 |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| US5670113A (en) | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
| US5210590A (en) | 1992-02-18 | 1993-05-11 | L. T. Industries, Inc. | Rapid scanning spectrographic analyzer |
| US5401465A (en) | 1992-05-05 | 1995-03-28 | Chiron Corporation | Luminometer with reduced sample crosstalk |
| JPH0634546A (ja) * | 1992-07-17 | 1994-02-08 | Tosoh Corp | 蛍光検出器 |
| CA2100020C (en) | 1992-07-17 | 2001-09-11 | Walter Blumenfeld | Methods and apparatus for detecting bacterial growth by spectrophotometric sampling of a fiber-optic array |
| WO1995030139A1 (en) | 1994-04-29 | 1995-11-09 | Perkin-Elmer Corporation | System for real time detection of nucleic acid amplification products |
| US5589351A (en) | 1994-12-06 | 1996-12-31 | Nps Pharmaceuticals, Inc. | Fluorescence detection apparatus |
| IT1280954B1 (it) * | 1995-10-05 | 1998-02-11 | Sorin Biomedica Cardio Spa | Procedimento e sistema per rilevare parametri chimico-fisici. |
| JPH10170444A (ja) | 1996-12-06 | 1998-06-26 | Hamamatsu Photonics Kk | 光測定装置 |
| JPH10197449A (ja) * | 1997-01-07 | 1998-07-31 | Hamamatsu Photonics Kk | 光測定装置 |
| JPH10281994A (ja) * | 1997-04-08 | 1998-10-23 | Hamamatsu Photonics Kk | 蛍光測定装置 |
| JPH10318929A (ja) | 1997-05-19 | 1998-12-04 | Toa Medical Electronics Co Ltd | 発光反応測定方法 |
| US6469311B1 (en) | 1997-07-16 | 2002-10-22 | Molecular Devices Corporation | Detection device for light transmitted from a sensed volume |
| US6043880A (en) | 1997-09-15 | 2000-03-28 | Becton Dickinson And Company | Automated optical reader for nucleic acid assays |
| US6982431B2 (en) * | 1998-08-31 | 2006-01-03 | Molecular Devices Corporation | Sample analysis systems |
| ES2224347T3 (es) * | 1998-05-01 | 2005-03-01 | F. Hoffmann-La Roche Ag | Aparato para controlar simultaneamente las reacciones que tienen lugaren una pluralidad de recipientes de reaccion. |
| EP0953838A1 (en) | 1998-05-01 | 1999-11-03 | F. Hoffmann-La Roche Ag | Apparatus for simultaneously monitoring reactions taking place in a plurality of reaction vessels |
| EP0953837A1 (en) * | 1998-05-01 | 1999-11-03 | F. Hoffmann-La Roche Ag | Fluorescence light measuring device and an apparatus wherein such a device is used |
| GB9815702D0 (en) * | 1998-07-21 | 1998-09-16 | Cambridge Imaging Ltd | Improved imaging system for fluorescence assays |
| US6569631B1 (en) | 1998-11-12 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes |
| US6838680B2 (en) * | 1999-05-12 | 2005-01-04 | Aclara Biosciences, Inc. | Multiplexed fluorescent detection in microfluidic devices |
| AU4307700A (en) | 1999-06-26 | 2001-01-31 | Packard Instrument Company, Inc. | Microplate reader |
| US6657169B2 (en) | 1999-07-30 | 2003-12-02 | Stratagene | Apparatus for thermally cycling samples of biological material with substantial temperature uniformity |
| EP1257805B1 (en) | 2000-02-10 | 2015-10-14 | Illumina, Inc. | Composition comprising a substrate with multiple assay locations for bead-based simultaneous processing of multiple samples, apparatus comprising the composition, and manufacturing method for the composition |
| US6690467B1 (en) | 2000-05-05 | 2004-02-10 | Pe Corporation | Optical system and method for optically analyzing light from a sample |
| JP2002098696A (ja) | 2000-09-26 | 2002-04-05 | Inst Of Physical & Chemical Res | 集積型生体分子センサー |
| EP2674745B1 (en) * | 2002-05-17 | 2016-04-13 | Life Technologies Corporation | Instrument for detecting and measuring fluorescence |
| GB0221167D0 (en) * | 2002-09-12 | 2002-10-23 | Quanta Biotech Ltd | Control apparatus |
| US7148043B2 (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
| JP2005077260A (ja) * | 2003-09-01 | 2005-03-24 | Fuji Photo Film Co Ltd | 化学発光検出方法およびシステム |
| US7177023B2 (en) | 2004-03-19 | 2007-02-13 | Applera Corporation | Fluorescent light detection |
| US20060030036A1 (en) | 2004-05-28 | 2006-02-09 | Victor Joseph | Chips for multiplex analyses |
| US7136550B2 (en) * | 2004-10-28 | 2006-11-14 | Corning Incorporated | Single-fiber launch/receive system for biosensing applications |
| WO2006116276A2 (en) * | 2005-04-28 | 2006-11-02 | Merck & Co., Inc. | Real-time hpv pcr assays |
| RU2304277C2 (ru) | 2005-06-23 | 2007-08-10 | Яков Игоревич Алексеев | Устройство для одновременного контроля в реальном масштабе времени множества амплификаций нуклеиновой кислоты |
| US20070098594A1 (en) | 2005-11-03 | 2007-05-03 | Roche Molecular Systems, Inc. | Analytical multi-spectral optical detection system |
| RU2307277C2 (ru) | 2005-11-15 | 2007-09-27 | Республиканское унитарное предприятие "Минский тракторный завод" | Предохранительный клапан |
| US7715001B2 (en) | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| DE102006036171B4 (de) | 2006-07-28 | 2008-10-09 | Analytik Jena Ag | Anordnung und Verfahren zur mehrkanaligen Fluoreszenzmessung in PCR-Proben |
| JP2008089321A (ja) * | 2006-09-29 | 2008-04-17 | Fujifilm Corp | バイオセンサ検出装置 |
| CN101821609A (zh) * | 2007-08-29 | 2010-09-01 | 艾本德股份有限公司 | 用于多个样品的辐射度测量的设备和方法 |
| EP2108942A1 (en) | 2008-04-09 | 2009-10-14 | F. Hoffmann-Roche AG | Reference light source device |
| CA2749247A1 (en) | 2009-01-08 | 2010-07-15 | It-Is International Ltd. | Optical system for chemical and/or biochemical reactions |
-
2010
- 2010-01-08 CA CA2749247A patent/CA2749247A1/en not_active Abandoned
- 2010-01-08 US US13/143,720 patent/US10029227B2/en active Active
- 2010-01-08 CN CN201080011733.5A patent/CN102341694B/zh active Active
- 2010-01-08 ES ES13151696T patent/ES2892342T3/es active Active
- 2010-01-08 WO PCT/GB2010/000028 patent/WO2010079338A2/en not_active Ceased
- 2010-01-08 ES ES10726151T patent/ES2875831T3/es active Active
- 2010-01-08 EP EP13151696.5A patent/EP2584344B1/en active Active
- 2010-01-08 DK DK13151696.5T patent/DK2584344T3/da active
- 2010-01-08 JP JP2011544920A patent/JP5864262B2/ja active Active
- 2010-01-08 EP EP10726151.3A patent/EP2376896B1/en active Active
- 2010-01-08 EP EP21169538.2A patent/EP3889586A1/en active Pending
- 2010-01-08 DE DE202010018011U patent/DE202010018011U1/de not_active Expired - Lifetime
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2013
- 2013-09-06 US US14/019,687 patent/US9089828B2/en active Active
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5864262B2 (ja) | 2016-02-17 |
| JP2012514747A (ja) | 2012-06-28 |
| EP2584344A3 (en) | 2013-07-31 |
| CN102341694B (zh) | 2018-03-23 |
| EP2376896A2 (en) | 2011-10-19 |
| US9089828B2 (en) | 2015-07-28 |
| EP2584344A2 (en) | 2013-04-24 |
| EP3889586A1 (en) | 2021-10-06 |
| CA2749247A1 (en) | 2010-07-15 |
| DK2584344T3 (da) | 2021-10-04 |
| EP2584344B1 (en) | 2021-06-30 |
| US20140005078A1 (en) | 2014-01-02 |
| CN102341694A (zh) | 2012-02-01 |
| EP2376896B1 (en) | 2021-05-19 |
| WO2010079338A2 (en) | 2010-07-15 |
| WO2010079338A3 (en) | 2010-11-18 |
| US10029227B2 (en) | 2018-07-24 |
| DE202010018011U1 (de) | 2013-07-10 |
| US20120014835A1 (en) | 2012-01-19 |
| JP2016095315A (ja) | 2016-05-26 |
| ES2875831T3 (es) | 2021-11-11 |
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