ES2877084T3 - Carga remota de fármacos poco solubles en agua en liposomas - Google Patents
Carga remota de fármacos poco solubles en agua en liposomas Download PDFInfo
- Publication number
- ES2877084T3 ES2877084T3 ES14745929T ES14745929T ES2877084T3 ES 2877084 T3 ES2877084 T3 ES 2877084T3 ES 14745929 T ES14745929 T ES 14745929T ES 14745929 T ES14745929 T ES 14745929T ES 2877084 T3 ES2877084 T3 ES 2877084T3
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- Prior art keywords
- liposomes
- agent
- liposome
- drug
- loading
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Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9636376B2 (en) * | 2012-09-11 | 2017-05-02 | Innopharma, Inc. | Stable compositions of peptide epoxy ketones |
ES2877084T3 (es) | 2013-02-01 | 2021-11-16 | Zoneone Pharma Inc | Carga remota de fármacos poco solubles en agua en liposomas |
US10220095B2 (en) | 2013-03-15 | 2019-03-05 | Taiwan Liposome Company, Ltd | Controlled drug release liposome compositions and methods thereof |
WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
US9993472B2 (en) | 2014-01-28 | 2018-06-12 | Unity Biotechnology, Inc. | Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2 |
US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
EP3177269A4 (en) | 2014-08-04 | 2018-02-28 | Zoneone Pharma, Inc. | Remote loading of sparingly water-soluble drugs into lipid vesicles |
US20170239182A1 (en) * | 2014-08-13 | 2017-08-24 | Mark E. Hayes | Pharmaceutical formulations of and methods to prepare chelating agents for efficient metal removal treatment systems |
WO2016025611A2 (en) * | 2014-08-13 | 2016-02-18 | Zoneone Pharma, Inc. | Pharmaceutical formulations of chelating agents as a metal removal treatment system |
CN105497871A (zh) * | 2014-09-25 | 2016-04-20 | 深圳翰宇药业股份有限公司 | 一种卡非佐米药物的脂质体冻干组合物及其制备方法 |
US20160220710A1 (en) * | 2015-01-30 | 2016-08-04 | The Regents Of The University Of Michigan | Compositions and methods for delivering pharmaceutical agents |
EP3271057B1 (en) | 2015-03-19 | 2019-09-04 | The University of Connecticut | Systems and methods for continuous manufacturing of liposomal drug formulations |
KR101730399B1 (ko) * | 2015-04-13 | 2017-04-27 | 영남대학교 산학협력단 | 악시티닙을 포함하는 약물 전달체 및 이의 제조방법 |
US9931298B2 (en) * | 2015-05-26 | 2018-04-03 | Comfort Care For Animals Llc | Liposome loading |
CN106317188A (zh) * | 2015-06-18 | 2017-01-11 | 重庆医药工业研究院有限责任公司 | 一种制备卡非佐米无定型物的方法 |
KR101723784B1 (ko) * | 2015-08-17 | 2017-04-07 | 가톨릭대학교 산학협력단 | c-ΜΕΤ 억제제를 유효성분으로 포함하는 독소루비신 및 광역학 치료 항암 효과 증진용 약학 조성물 |
US20170065520A1 (en) * | 2015-09-09 | 2017-03-09 | Manli International Ltd | Stable liposomal formulations of rapamycin and rapamycin derivatives for treating cancer |
US20170119666A1 (en) * | 2015-10-29 | 2017-05-04 | Peregrine Ophthalmic PTE LTD. | Stable liposomal formulations of alpha 2 adrenergic agonists for ocular delivery |
SG10202007520WA (en) | 2016-03-02 | 2020-09-29 | Eisai R&D Man Co Ltd | Eribulin-based antibody-drug conjugates and methods of use |
CN105784453B (zh) * | 2016-03-16 | 2018-04-13 | 吉林省水产科学研究院 | 鱼肉中阿维菌素和伊维菌素残留检测的前处理方法 |
TWI754659B (zh) * | 2016-08-08 | 2022-02-11 | 台灣微脂體股份有限公司 | 用於製備含有弱酸性劑之微脂體組合物的傳輸載體、方法及套組 |
ES2968358T3 (es) * | 2016-12-26 | 2024-05-09 | Fujifilm Corp | Composición de partículas lipídicas y composición farmacéutica |
KR20190122676A (ko) * | 2017-01-18 | 2019-10-30 | 테마섹 라이프 사이언스 래보러토리 리미티드 | 유사분열기세포의 표적화를 증가시키는 고안정화된 리포좀 |
CN108853507A (zh) * | 2017-05-11 | 2018-11-23 | 复旦大学 | 一种抗肿瘤的增效药物组合物及其制备方法和用途 |
CN108703971B (zh) * | 2017-07-11 | 2023-04-07 | 南华大学 | 抗hiv药物可比司它用于制备抗血栓药物的用途 |
CN109364025A (zh) * | 2017-11-17 | 2019-02-22 | 和龙 | 脂质体组合物、其制备方法及其应用 |
EP3731846A4 (en) * | 2017-12-29 | 2022-03-02 | Wayne State University | DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF INFECTIONS |
KR102046355B1 (ko) * | 2018-02-08 | 2019-11-19 | 국방과학연구소 | 피하주사용 피소스티그민의 서방출성 리포좀 제제 및 이의 제조 방법 |
US20190275102A1 (en) * | 2018-03-06 | 2019-09-12 | Cadila Healthcare Limited | Sterile injectable composition comprising carfilzomib |
AU2019261329B2 (en) * | 2018-04-23 | 2024-09-05 | Inspirmed Corp. | Inhalable liposomal sustained release composition for use in treating pulmonary diseases |
WO2020023445A1 (en) * | 2018-07-24 | 2020-01-30 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising a therapeutic agent for treating dementia and uses thereof |
EP3829539A4 (en) * | 2018-08-02 | 2022-05-04 | Taiwan Liposome Company, Ltd. | EXTENDED RELEASE COMPOSITIONS COMPRISING A THERAPEUTIC AGENT FOR THE TREATMENT OF DEPRESSION OR ANXIETY AND USES THEREOF |
WO2020033195A1 (en) * | 2018-08-08 | 2020-02-13 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising an antipsychotic drug and uses thereof |
US20220054455A1 (en) * | 2018-09-13 | 2022-02-24 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising of a sedative drug and uses thereof |
TWI729562B (zh) * | 2018-11-14 | 2021-06-01 | 台灣微脂體股份有限公司 | 包含用於治療因骨密度降低或軟骨損失導致之疾病的治療劑的緩釋藥物組合物及其用途 |
CN109528654B (zh) * | 2018-12-14 | 2021-04-23 | 沈阳药科大学 | 一种盐酸伊立替康和盐酸阿霉素共载脂质体及其制备方法 |
WO2020150412A1 (en) * | 2019-01-16 | 2020-07-23 | Purdue Research Foundation | Preparing liposomes with high drug loading capacity and the use thereof |
EP3968951A1 (en) * | 2019-05-14 | 2022-03-23 | Inspirmed Corp | Inhalable sustained release composition of bronchodilator for use in treating pulmonary disease |
WO2021209947A1 (en) * | 2020-04-15 | 2021-10-21 | Kashiv Biosciences, Llc | Stable ready to dilute formulations of carfilzomib |
CN115666552B (zh) | 2020-05-29 | 2024-09-13 | 江苏恒瑞医药股份有限公司 | 含有乙二胺四乙酸或其盐的艾日布林或其可药用盐脂质体 |
WO2022124898A1 (en) * | 2020-12-09 | 2022-06-16 | Erasmus University Medical Center Rotterdam | Auristatin-loaded liposomes and uses thereof. |
CN112851789B (zh) * | 2021-02-04 | 2022-10-18 | 大理大学 | 一种脑靶向hiv进入抑制剂多肽及其应用 |
CN115006532A (zh) * | 2021-03-05 | 2022-09-06 | 广州医科大学 | 蛋白酶体抑制剂的应用 |
WO2023029041A1 (zh) * | 2021-09-06 | 2023-03-09 | 北京茵诺医药科技有限公司 | 靶向动脉粥样硬化脂质体纳米载体递送系统及其制备方法 |
CN114344303B (zh) * | 2022-01-13 | 2023-05-09 | 江苏海洋大学 | 一种新型精神药物固体分散体及制备方法和应用 |
CN114832113B (zh) * | 2022-03-22 | 2023-06-20 | 重庆医科大学 | 疏水药物-马来酰亚胺衍生物及其主动载药脂质体和应用 |
WO2024010886A2 (en) * | 2022-07-07 | 2024-01-11 | Nanostar Pharmaceuticals Ltd. | Multilamellar vesicle drug formulation |
CN115154428B (zh) * | 2022-09-06 | 2023-01-10 | 上海奥科达医药科技股份有限公司 | 一种地拉罗司药物组合物及其制备方法 |
CN116027000B (zh) * | 2022-12-30 | 2024-05-17 | 南京明捷生物医药检测有限公司 | 一种检测白蛋白脂质体纳米粒体外溶出度的方法 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932657A (en) | 1973-11-12 | 1976-01-13 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome encapsulation of chelating agents |
US4016290A (en) | 1973-11-12 | 1977-04-05 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes |
US4310506A (en) | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
NZ201010A (en) | 1981-06-19 | 1986-02-21 | Ciba Geigy Ag | The treatment of inflammation diseases using desferrioxamine |
US5043166A (en) | 1987-01-09 | 1991-08-27 | Hadasit Medical Research, Inc. | Liposome/anthraquinone drug composition and method |
MX9203808A (es) | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
US5534241A (en) | 1993-07-23 | 1996-07-09 | Torchilin; Vladimir P. | Amphipathic polychelating compounds and methods of use |
DE4341472A1 (de) * | 1993-12-02 | 1995-06-08 | Schering Ag | Verfahren zur Erhöhung der Stabilität von hydrophile Wirkstoffe enthaltenden Liposomensuspensionen |
US5800833A (en) | 1995-02-27 | 1998-09-01 | University Of British Columbia | Method for loading lipid vesicles |
WO1996032930A1 (en) | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
US6447800B2 (en) | 1996-01-18 | 2002-09-10 | The University Of British Columbia | Method of loading preformed liposomes using ethanol |
US5837282A (en) | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
US5827532A (en) * | 1997-01-31 | 1998-10-27 | The Reagents Of The University Of California | Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations |
US7112338B2 (en) | 1997-03-12 | 2006-09-26 | The Regents Of The University Of California | Cationic liposome delivery of taxanes to angiogenic blood vessels |
AU754559B2 (en) | 1998-08-12 | 2002-11-21 | New York University | Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient |
AU2609601A (en) | 1999-12-30 | 2001-07-16 | Judith K. Gwathmey | Iron chelator delivery system |
US8029795B2 (en) | 1999-12-30 | 2011-10-04 | Gwathmey, Inc. | Targeted iron chelator delivery system |
US7485320B2 (en) * | 2000-09-25 | 2009-02-03 | Industrial Technology Research Institute | Liposome for incorporating large amounts of hydrophobic substances |
US6984395B2 (en) * | 2001-04-11 | 2006-01-10 | Qlt, Inc. | Drug delivery system for hydrophobic drugs |
EP1429726A2 (en) * | 2001-09-06 | 2004-06-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A method for preparing liposome formulations with a predefined release profile |
US20050208119A1 (en) | 2004-03-18 | 2005-09-22 | Takemoto Arnold C | Encapsulated oral chelating preparations |
ES2967961T3 (es) | 2004-05-03 | 2024-05-06 | Ipsen Biopharm Ltd | Liposomas útiles en la administración de fármacos |
US8658203B2 (en) * | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
CA2596131A1 (en) | 2005-01-28 | 2006-08-03 | Bc Cancer Agency | Liposomal compositions for parenteral delivery of agents |
TW200726485A (en) * | 2005-07-01 | 2007-07-16 | Alza Corp | Liposomal delivery vehicle for hydrophobic drugs |
US20120021042A1 (en) * | 2005-09-15 | 2012-01-26 | Steffen Panzner | Efficient Method For Loading Amphoteric Liposomes With Nucleic Acid Active Substances |
US20080107747A1 (en) * | 2006-10-23 | 2008-05-08 | Roederer Joy E | Pain relief composition |
JP2010536874A (ja) * | 2007-08-21 | 2010-12-02 | アルザ・コーポレーシヨン | ボロン酸化合物をインビボ投与するためのリポソーム組成物 |
US20090196917A1 (en) * | 2008-02-01 | 2009-08-06 | University Of Kentucky Research Foundation | Liposomal Formulations of Hydrophobic Lactone Drugs in the Presence of Metal Ions |
US8481526B2 (en) * | 2009-03-25 | 2013-07-09 | Bausch & Lomb Incorporated | Fluoroquinolone carboxylic acid molecular crystals |
RS55148B1 (sr) * | 2009-03-30 | 2016-12-30 | Eisai R&D Man Co Ltd | Smeša lipozoma |
EP2480209A1 (en) * | 2009-09-23 | 2012-08-01 | Indu Javeri | Methods for the preparation of liposomes comprising docetaxel |
CA2776925C (en) | 2009-10-26 | 2018-07-24 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Liposome having inner water phase containing sulfobutyl ether cyclodextrin salt |
WO2011090940A1 (en) * | 2010-01-19 | 2011-07-28 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
WO2011092708A2 (en) * | 2010-02-01 | 2011-08-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Liposomes comprising amphipathic drugs and method for their preparation |
WO2012118376A1 (en) * | 2011-03-01 | 2012-09-07 | To-Bbb Holding B.V. | Advanced active liposomal loading of poorly water-soluble substances |
ES2877084T3 (es) | 2013-02-01 | 2021-11-16 | Zoneone Pharma Inc | Carga remota de fármacos poco solubles en agua en liposomas |
WO2014153192A1 (en) | 2013-03-14 | 2014-09-25 | Zoneone Pharma, Inc. | Pharmaceutical formulations of chelating agents as a metal removal treatment system |
EP3177269A4 (en) * | 2014-08-04 | 2018-02-28 | Zoneone Pharma, Inc. | Remote loading of sparingly water-soluble drugs into lipid vesicles |
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