SG11201506014VA - Remote loading of sparingly water-soluble drugs into liposomes - Google Patents

Remote loading of sparingly water-soluble drugs into liposomes

Info

Publication number
SG11201506014VA
SG11201506014VA SG11201506014VA SG11201506014VA SG11201506014VA SG 11201506014V A SG11201506014V A SG 11201506014VA SG 11201506014V A SG11201506014V A SG 11201506014VA SG 11201506014V A SG11201506014V A SG 11201506014VA SG 11201506014V A SG11201506014V A SG 11201506014VA
Authority
SG
Singapore
Prior art keywords
liposomes
soluble drugs
sparingly water
remote loading
loading
Prior art date
Application number
SG11201506014VA
Inventor
Mark E Hayes
Charles O Noble
Francis C Szoka Jr
Original Assignee
Zoneone Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoneone Pharma Inc filed Critical Zoneone Pharma Inc
Publication of SG11201506014VA publication Critical patent/SG11201506014VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
SG11201506014VA 2013-02-01 2014-02-03 Remote loading of sparingly water-soluble drugs into liposomes SG11201506014VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361759914P 2013-02-01 2013-02-01
PCT/US2014/014480 WO2014121211A2 (en) 2013-02-01 2014-02-03 Remote loading of sparingly water-soluble drugs into liposomes

Publications (1)

Publication Number Publication Date
SG11201506014VA true SG11201506014VA (en) 2015-08-28

Family

ID=51259399

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201506014VA SG11201506014VA (en) 2013-02-01 2014-02-03 Remote loading of sparingly water-soluble drugs into liposomes
SG10201706239VA SG10201706239VA (en) 2013-02-01 2014-02-03 Remote loading of sparingly water-soluble drugs into liposomes

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201706239VA SG10201706239VA (en) 2013-02-01 2014-02-03 Remote loading of sparingly water-soluble drugs into liposomes

Country Status (15)

Country Link
US (6) US20140220111A1 (en)
EP (3) EP2950784B1 (en)
KR (2) KR102310786B1 (en)
CN (1) CN105163720B (en)
AU (2) AU2014212096B2 (en)
CA (1) CA2899882C (en)
DK (2) DK3922241T3 (en)
ES (2) ES2964512T3 (en)
FI (1) FI3922241T3 (en)
HR (1) HRP20231522T1 (en)
PT (1) PT2950784T (en)
SG (2) SG11201506014VA (en)
SI (1) SI3922241T1 (en)
WO (1) WO2014121211A2 (en)
ZA (2) ZA201506400B (en)

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Also Published As

Publication number Publication date
KR102310786B1 (en) 2021-10-12
EP4309657A2 (en) 2024-01-24
AU2019200756A1 (en) 2019-02-21
DK2950784T3 (en) 2021-07-05
CN105163720A (en) 2015-12-16
CN105163720B (en) 2019-10-11
US20140220110A1 (en) 2014-08-07
EP3922241B1 (en) 2023-11-15
EP2950784B1 (en) 2021-04-07
US20140220111A1 (en) 2014-08-07
KR20150139500A (en) 2015-12-11
CA2899882C (en) 2023-12-12
US20160324780A1 (en) 2016-11-10
CA2899882A1 (en) 2014-08-07
HRP20231522T1 (en) 2024-03-01
ZA201506400B (en) 2020-12-23
AU2014212096A1 (en) 2015-09-17
EP2950784A2 (en) 2015-12-09
FI3922241T3 (en) 2023-11-28
ES2964512T3 (en) 2024-04-08
SI3922241T1 (en) 2024-03-29
KR102554628B1 (en) 2023-07-12
WO2014121211A2 (en) 2014-08-07
US20190314282A1 (en) 2019-10-17
US10722467B2 (en) 2020-07-28
DK3922241T3 (en) 2023-12-04
US10507182B2 (en) 2019-12-17
KR20210122321A (en) 2021-10-08
EP3922241A1 (en) 2021-12-15
SG10201706239VA (en) 2017-08-30
WO2014121211A3 (en) 2015-01-08
ZA202001372B (en) 2024-01-31
PT2950784T (en) 2021-06-30
US20170202776A1 (en) 2017-07-20
EP4309657A3 (en) 2024-02-28
AU2014212096B2 (en) 2018-11-08
EP2950784A4 (en) 2016-11-09
US20190110991A1 (en) 2019-04-18
US9737485B2 (en) 2017-08-22
ES2877084T3 (en) 2021-11-16

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