ES2875327T3 - Producción de oligosacáridos - Google Patents
Producción de oligosacáridos Download PDFInfo
- Publication number
- ES2875327T3 ES2875327T3 ES13183670T ES13183670T ES2875327T3 ES 2875327 T3 ES2875327 T3 ES 2875327T3 ES 13183670 T ES13183670 T ES 13183670T ES 13183670 T ES13183670 T ES 13183670T ES 2875327 T3 ES2875327 T3 ES 2875327T3
- Authority
- ES
- Spain
- Prior art keywords
- lacto
- oligosaccharide
- glucosidase
- host microorganism
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000002482 oligosaccharides Chemical class 0.000 title claims abstract description 128
- 229920001542 oligosaccharide Polymers 0.000 title claims abstract description 125
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 40
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- 102000004366 Glucosidases Human genes 0.000 claims abstract description 55
- 108010056771 Glucosidases Proteins 0.000 claims abstract description 55
- 238000000034 method Methods 0.000 claims abstract description 55
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 35
- 239000000758 substrate Substances 0.000 claims abstract description 23
- 239000000543 intermediate Substances 0.000 claims abstract description 16
- 235000020256 human milk Nutrition 0.000 claims abstract description 11
- 239000006227 byproduct Substances 0.000 claims abstract description 10
- 210000004251 human milk Anatomy 0.000 claims abstract description 10
- 230000001851 biosynthetic effect Effects 0.000 claims abstract description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 36
- 108010005774 beta-Galactosidase Proteins 0.000 claims description 33
- 102000005936 beta-Galactosidase Human genes 0.000 claims description 32
- 102000004169 proteins and genes Human genes 0.000 claims description 32
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- 230000006652 catabolic pathway Effects 0.000 claims description 27
- 150000002772 monosaccharides Chemical class 0.000 claims description 25
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 24
- 230000008569 process Effects 0.000 claims description 20
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- 239000000047 product Substances 0.000 claims description 17
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- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims description 11
- 230000015556 catabolic process Effects 0.000 claims description 11
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13183670.2A EP2845905B8 (en) | 2013-09-10 | 2013-09-10 | Production of oligosaccharides |
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| ES2875327T3 true ES2875327T3 (es) | 2021-11-10 |
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| ES13183670T Active ES2875327T3 (es) | 2013-09-10 | 2013-09-10 | Producción de oligosacáridos |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2875327T3 (es) * | 2013-09-10 | 2021-11-10 | Chr Hansen Hmo Gmbh | Producción de oligosacáridos |
| PL2896628T3 (pl) * | 2014-01-20 | 2019-03-29 | Jennewein Biotechnologie Gmbh | Sposób wydajnego oczyszczania obojętnych oligosacharydów ludzkiego mleka (HMO) z fermentacji mikrobiologicznej |
| ES2971093T3 (es) * | 2015-03-31 | 2024-06-03 | Glycom As | Mezclas de oligosacáridos de la leche humana que comprenden 3'-O-sialilactosa |
| US10829508B2 (en) | 2015-12-18 | 2020-11-10 | Glycom A/S | Fermentative production of oligosaccharides |
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