ES2855225T3 - Heterociclos tricíclicos para su uso como inhibidores de proteínas BET - Google Patents
Heterociclos tricíclicos para su uso como inhibidores de proteínas BET Download PDFInfo
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- ES2855225T3 ES2855225T3 ES15771373T ES15771373T ES2855225T3 ES 2855225 T3 ES2855225 T3 ES 2855225T3 ES 15771373 T ES15771373 T ES 15771373T ES 15771373 T ES15771373 T ES 15771373T ES 2855225 T3 ES2855225 T3 ES 2855225T3
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- Prior art keywords
- cancer
- butyl
- methyl
- compound
- pyridin
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- 229940121649 protein inhibitor Drugs 0.000 title description 2
- 239000012268 protein inhibitor Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 229
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 88
- 150000003839 salts Chemical class 0.000 claims abstract description 56
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 33
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims abstract description 33
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract description 32
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 19
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 15
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims abstract description 14
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims abstract description 14
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 13
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 13
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 13
- DLGYNVMUCSTYDQ-UHFFFAOYSA-N azane;pyridine Chemical compound N.C1=CC=NC=C1 DLGYNVMUCSTYDQ-UHFFFAOYSA-N 0.000 claims abstract description 8
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- 208000035475 disorder Diseases 0.000 claims description 22
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 21
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 21
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- 125000003545 alkoxy group Chemical group 0.000 claims description 17
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462050500P | 2014-09-15 | 2014-09-15 | |
| PCT/US2015/049909 WO2016044130A1 (en) | 2014-09-15 | 2015-09-14 | Tricyclic heterocycles for use as bet protein inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2855225T3 true ES2855225T3 (es) | 2021-09-23 |
Family
ID=54207768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15771373T Active ES2855225T3 (es) | 2014-09-15 | 2015-09-14 | Heterociclos tricíclicos para su uso como inhibidores de proteínas BET |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US9527864B2 (OSRAM) |
| EP (1) | EP3194406B8 (OSRAM) |
| JP (1) | JP6599979B2 (OSRAM) |
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- 2015-09-14 US US14/852,958 patent/US9527864B2/en active Active
- 2015-09-14 JP JP2017514515A patent/JP6599979B2/ja active Active
- 2015-09-14 TW TW104130337A patent/TWI712603B/zh active
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| US9527864B2 (en) | 2016-12-27 |
| TW201613935A (en) | 2016-04-16 |
| EP3194406B8 (en) | 2021-03-31 |
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| US20170158710A1 (en) | 2017-06-08 |
| TWI712603B (zh) | 2020-12-11 |
| EP3194406A1 (en) | 2017-07-26 |
| JP2017526731A (ja) | 2017-09-14 |
| EP3194406B1 (en) | 2020-12-16 |
| US20160075721A1 (en) | 2016-03-17 |
| US9834565B2 (en) | 2017-12-05 |
| US10227359B2 (en) | 2019-03-12 |
| JP6599979B2 (ja) | 2019-10-30 |
| US10618910B2 (en) | 2020-04-14 |
| US20180222920A1 (en) | 2018-08-09 |
| US20190233435A1 (en) | 2019-08-01 |
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