ES2843973T3 - Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3 - Google Patents
Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3 Download PDFInfo
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- ES2843973T3 ES2843973T3 ES15811480T ES15811480T ES2843973T3 ES 2843973 T3 ES2843973 T3 ES 2843973T3 ES 15811480 T ES15811480 T ES 15811480T ES 15811480 T ES15811480 T ES 15811480T ES 2843973 T3 ES2843973 T3 ES 2843973T3
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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| US201462018445P | 2014-06-27 | 2014-06-27 | |
| PCT/US2015/037980 WO2015200795A1 (en) | 2014-06-27 | 2015-06-26 | Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases |
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| DK2428513T3 (en) | 2006-09-26 | 2017-08-21 | Celgene Corp | 5-substituted quinazolinone derivatives as anti-cancer agents |
| HRP20171078T1 (hr) | 2010-02-11 | 2017-10-06 | Celgene Corporation | Derivati arilmetoksi izoindolina i pripravci koji ih sadrže, te postupci njihove uporabe |
| US8802685B2 (en) | 2011-03-11 | 2014-08-12 | Celgene Corporation | Solid forms of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
| WO2014039421A1 (en) | 2012-09-04 | 2014-03-13 | Celgene Corporation | Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2-6-dione and methods of preparation thereof |
| WO2014116573A1 (en) | 2013-01-22 | 2014-07-31 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| EP3827836A1 (en) | 2014-06-27 | 2021-06-02 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| EA201792214A1 (ru) | 2015-04-10 | 2018-01-31 | Араксис Фарма Ллк | Соединения замещенного хиназолина |
| CA2982360A1 (en) | 2015-04-15 | 2016-10-20 | Liansheng Li | Fused-tricyclic inhibitors of kras and methods of use thereof |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| EP3356351A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10875842B2 (en) | 2015-09-28 | 2020-12-29 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10689356B2 (en) | 2015-09-28 | 2020-06-23 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
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| US20160313300A1 (en) | 2013-12-06 | 2016-10-27 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| EP3827836A1 (en) | 2014-06-27 | 2021-06-02 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| US9713375B1 (en) | 2015-02-26 | 2017-07-25 | Brett Einar Rahm | Collapsible portable table |
| WO2017117118A1 (en) | 2015-12-28 | 2017-07-06 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
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| US20210000813A1 (en) | 2021-01-07 |
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| EP3160486A4 (en) | 2017-12-13 |
| EP3160486A1 (en) | 2017-05-03 |
| WO2015200795A1 (en) | 2015-12-30 |
| EP3160486B1 (en) | 2020-11-18 |
| JP6640126B2 (ja) | 2020-02-05 |
| JP2017528690A (ja) | 2017-09-28 |
| US20190030019A1 (en) | 2019-01-31 |
| US10668057B2 (en) | 2020-06-02 |
| US10092555B2 (en) | 2018-10-09 |
| US11419861B2 (en) | 2022-08-23 |
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