ES2837854T3 - Composiciones bioactivas derivables de concentrados plaquetarios y procedimientos para prepararlas y utilizarlas - Google Patents

Composiciones bioactivas derivables de concentrados plaquetarios y procedimientos para prepararlas y utilizarlas

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Publication number
ES2837854T3
ES2837854T3 ES14766283T ES14766283T ES2837854T3 ES 2837854 T3 ES2837854 T3 ES 2837854T3 ES 14766283 T ES14766283 T ES 14766283T ES 14766283 T ES14766283 T ES 14766283T ES 2837854 T3 ES2837854 T3 ES 2837854T3
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Spain
Prior art keywords
liquid
platelet
bioactive fraction
clot
filter
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ES14766283T
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English (en)
Spanish (es)
Inventor
Erik Woods
Christopher Taylor
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Cook General Biotechnolgy LLC
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Cook General Biotechnolgy LLC
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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ES14766283T 2013-08-27 2014-08-27 Composiciones bioactivas derivables de concentrados plaquetarios y procedimientos para prepararlas y utilizarlas Active ES2837854T3 (es)

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Application Number Priority Date Filing Date Title
US201361870686P 2013-08-27 2013-08-27
PCT/US2014/052885 WO2015031465A1 (en) 2013-08-27 2014-08-27 Bioactive compositions derivable from platelet concentrates, and methods for preparing and using same

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ES2837854T3 true ES2837854T3 (es) 2021-07-01

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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013003356A1 (en) * 2011-06-27 2013-01-03 Emory University Compositions, uses, and preparation of platelet lysates
DE102015205293A1 (de) 2015-03-24 2016-09-29 Marc Schrott Verfahren zur Herstellung von Augentropfen
AU2016270679B2 (en) * 2015-05-29 2021-08-19 Jadi Cell Llc Particulate lyophilized platelet lysate compositions
FR3036707B1 (fr) * 2015-05-29 2019-05-17 Maco Pharma Procede de sterilisation d'un lysat plaquettaire
ES2633815B1 (es) * 2016-03-23 2018-07-06 Biotechnology Institute I Mas D, S.L. Formulación de aplicación tópica, rica en plaquetas y/o factores de crecimiento y un método de preparación de la misma
HUE067544T2 (hu) * 2016-11-18 2024-11-28 Power Of Platelets Pte Ltd Módszer növekedési faktorokat tartalmazó vérlemezke-releasate elõállítására és annak felhasználása
CN110891582A (zh) * 2017-06-16 2020-03-17 里尔大学中心医院 制备混合人血小板裂解液的方法、混合人血小板裂解液及其用于治疗神经系统疾病的用途
JP2022519781A (ja) * 2019-02-07 2022-03-24 バイオブリッジ グローバル 血小板放出物および多血小板フィブリンに関する方法および組成物
US20230270791A1 (en) * 2020-07-31 2023-08-31 Rainbow (Rainbow Inc.) Platelet lysate derived from autologous platelets
JP7313098B2 (ja) * 2021-02-26 2023-07-24 株式会社同仁がん免疫研究所 成長因子混合物を調整する方法
KR102656373B1 (ko) * 2021-06-25 2024-04-12 서울대학교병원 난소 조직 이식용 하이드로겔
EP4373951A1 (en) * 2021-07-19 2024-05-29 2seventy bio, Inc. Vector manufacturing processes
EP4276173A1 (en) * 2022-05-10 2023-11-15 Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. Stable human platelet lysate composition, methods and uses thereof
CN115125191B (zh) * 2022-08-22 2023-10-13 浙江绿蔻生物技术有限公司 成纤维细胞转化培养基及其应用、成纤维细胞的制备方法
CN119454910B (zh) * 2023-08-10 2025-10-28 四川大学华西医院 一种仿血小板凝胶修复制剂及其制备方法和促进伤口愈合的用途
WO2025085793A1 (en) * 2023-10-20 2025-04-24 Ossium Health, Inc. Compositions and methods comprising tissue implants
WO2025184489A1 (en) 2024-02-29 2025-09-04 Consano Bio, Inc. Allogeneic human plasma and platelet derived products and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520107A (en) * 1982-09-28 1985-05-28 Polydex Chemicals Ltd. Tissue culture and cell growth-promoting material and its method of manufacture
SE8801537D0 (sv) * 1988-04-26 1988-04-26 Ellco Food Ab Cellodlingsmedium samt forfarande for dess framstellning
SE528214C2 (sv) * 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
US20090305401A1 (en) 2006-09-18 2009-12-10 Dirk Strunk Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
EP2077118A1 (en) 2008-01-07 2009-07-08 Gwo Rei Biomedical Technology Corp. Clottable concentrate of platelet growth factors and preparation method thereof
IT1392897B1 (it) * 2008-07-18 2012-04-02 Fond Ircss Ca' Granda - Ospedale Maggiore Policlinico Frazione piastrinica derivante da sangue placentare
EP2334785B2 (en) 2008-09-16 2019-08-14 Mayo Foundation For Medical Education And Research Compositions containing platelet contents
US20130017180A1 (en) * 2010-04-05 2013-01-17 Allan Mishra Platelet rich plasma formulations
CA2809272A1 (en) 2010-08-31 2012-03-08 Cook General Biotechnology Llc Systemic, allogenic stem cell therapies for treatment of diseases in animals
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
WO2013003356A1 (en) * 2011-06-27 2013-01-03 Emory University Compositions, uses, and preparation of platelet lysates
US8430521B2 (en) * 2011-07-02 2013-04-30 Jet Motor Limited Pool lighting assembly
EP2733200A1 (en) 2012-11-15 2014-05-21 Biorigen International SA Cell culture supplements
PL2956150T3 (pl) * 2013-02-12 2022-01-03 Lacerta Technologies Inc. Frakcja surowicy z fibryny bogatopłytkowej

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