ES2836948T3 - Proteínas de unión que inhiben la interacción del receptor de VEGF-A - Google Patents
Proteínas de unión que inhiben la interacción del receptor de VEGF-A Download PDFInfo
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- ES2836948T3 ES2836948T3 ES09756279T ES09756279T ES2836948T3 ES 2836948 T3 ES2836948 T3 ES 2836948T3 ES 09756279 T ES09756279 T ES 09756279T ES 09756279 T ES09756279 T ES 09756279T ES 2836948 T3 ES2836948 T3 ES 2836948T3
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| WO2007062676A1 (en) | 2005-12-01 | 2007-06-07 | B.R.A.H.M.S. Aktiengesellschaft | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| EP2004697A2 (en) | 2006-04-07 | 2008-12-24 | The Procter & Gamble Company | Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| AU2014243418B2 (en) * | 2010-04-30 | 2016-09-22 | Molecular Partners Ag | Modified binding proteins inhibiting the VEGF-A receptor interaction |
| CA2818969C (en) | 2010-11-26 | 2020-04-14 | Molecular Partners Ag | Improved n-terminal capping modules for designed ankyrin repeat proteins |
| JP2014519808A (ja) | 2011-04-29 | 2014-08-21 | ヤンセン バイオテツク，インコーポレーテツド | Ｉｌ４／ｉｌ１３に結合する反復タンパク質及び使用 |
| WO2012172054A1 (en) | 2011-06-16 | 2012-12-20 | Scil Proteins Gmbh | Modified multimeric ubiquitin proteins binding vegf-a |
| CA2850830A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| WO2013072510A1 (en) | 2011-11-16 | 2013-05-23 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition |
| US9402900B2 (en) | 2011-11-16 | 2016-08-02 | Adrenomed Ag | Methods of modulating adrenomedullin by administering an anti-adrenomedullin (ADM) antibody |
| SG11201402354YA (en) | 2011-11-16 | 2014-06-27 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease |
| US9304127B2 (en) | 2011-11-16 | 2016-04-05 | Adrenomed Ag | Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment for use in therapy |
| KR102047443B1 (ko) | 2011-11-16 | 2019-11-25 | 아드레노메드 아게 | 요법에 사용하기 위한 항-아드레노메둘린 (adm) 항체 또는 항-adm 항체 단편 또는 항-adm 비-ig 스캐폴드 |
| HRP20191010T1 (hr) | 2011-11-16 | 2019-08-23 | Adrenomed Ag | Protutijelo protiv adrenomedulina (adm) ili fragment protutijela protiv adm ili ne-ig okosnica protutijela protiv adm, namijenjeno sprječavanju ili smanjivanju disfunkcije organa ili insuficijencije organa kod pacijenta s kroničnom ili akutnom bolešću ili akutnim stanjem |
| CN103308673B (zh) | 2012-03-08 | 2017-05-31 | 思芬构技术有限公司 | 用于预测雌性对象中发生心血管事件的风险的方法 |
| CN103308670B (zh) | 2012-03-08 | 2017-06-09 | 思芬构技术有限公司 | 用于预测对象患糖尿病和/或代谢综合征的风险的方法 |
| CN103308689B (zh) | 2012-03-08 | 2017-04-12 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
| ES2753135T3 (es) * | 2012-05-07 | 2020-04-07 | Allergan Inc | Método de tratamiento de DMAE en pacientes resistentes a terapia anti-VEGF |
| DK3536310T3 (da) | 2012-06-01 | 2021-07-19 | Novartis Ag | Sprøjte |
| KR20150023957A (ko) * | 2012-06-28 | 2015-03-05 | 몰리큘라 파트너스 아게 | 혈소판-유래 성장인자에 결합하는 설계된 안키린 반복 단백질 |
| DE202012011016U1 (de) | 2012-07-03 | 2012-11-28 | Novartis Ag | Aflibercept-Spritze |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
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| US20150297675A1 (en) * | 2012-08-28 | 2015-10-22 | Aaron Osborne | Use of a vegf antagonist in treating ocular vascular proliferative diseases |
| US9664695B2 (en) | 2012-10-02 | 2017-05-30 | Sphingotec Gmbh | Method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| EP2943795B1 (en) | 2013-01-08 | 2021-02-24 | sphingotec GmbH | Fasting levels of growth hormone as a predictive marker of cardiovascular risk |
| MX2015010350A (es) * | 2013-02-26 | 2015-10-29 | Roche Glycart Ag | Moleculas de union a antigeno biespecificas que activan la celula t. |
| CN105188759A (zh) * | 2013-03-14 | 2015-12-23 | 阿勒根公司 | 持续释放递送的组合物以及在制造过程中稳定蛋白质的方法 |
| DK2976646T3 (da) | 2013-03-20 | 2020-11-16 | Sphingotec Gmbh | Adrenomedullin til føring af terapi af blodtryksfald |
| FR3004650B1 (fr) * | 2013-04-22 | 2015-05-29 | Affilogic | Composition topique comprenant un variant d'une protéine sauvage à pli-OB, ainsi que son procédé de préparation |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| US20160130321A1 (en) | 2013-06-20 | 2016-05-12 | Gabriela Burian | Use of a vegf antagonist in treating macular edema |
| JP2016522249A (ja) | 2013-06-20 | 2016-07-28 | ノバルティス アーゲー | 脈絡膜血管新生の治療におけるｖｅｇｆアンタゴニストの使用 |
| EP3010542A1 (en) | 2013-06-20 | 2016-04-27 | Novartis AG | Treatment of polypoidal choroidal vasculopathy |
| RU2676274C2 (ru) | 2013-07-11 | 2018-12-27 | Новартис Аг | Применение антагониста vegf при лечении хориоретинальных неоваскулярных нарушений и нарушений проницаемости у педиатрических пациентов |
| EP3019527A2 (en) | 2013-07-11 | 2016-05-18 | Novartis AG | Use of a vegf antagonist in treating retinopathy of prematurity |
| KR20160030396A (ko) | 2013-07-12 | 2016-03-17 | 옵쏘테크 코포레이션 | 안과적 질환을 치료하거나 예방하기 위한 방법 |
| DK3065761T3 (da) * | 2013-11-05 | 2020-02-17 | Allergan Inc | Fremgangsmåde til behandling af tilstande af øjet med en anti-vegf darpin |
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| JP2015133978A (ja) | 2015-07-27 |
| CA2742241A1 (en) | 2010-06-03 |
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| BRPI0921469B1 (pt) | 2022-01-18 |
| IL212589A (en) | 2017-01-31 |
| AU2009319204A1 (en) | 2010-06-03 |
| RU2550258C2 (ru) | 2015-05-10 |
| BRPI0921469A2 (pt) | 2016-01-12 |
| CN107011425B (zh) | 2021-01-01 |
| EP2358746B1 (en) | 2020-09-16 |
| KR101698362B1 (ko) | 2017-01-20 |
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| US20110207668A1 (en) | 2011-08-25 |
| CN102272148A (zh) | 2011-12-07 |
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| WO2010060748A1 (en) | 2010-06-03 |
| AU2009319204B2 (en) | 2014-11-13 |
| US20150344539A1 (en) | 2015-12-03 |
| IL212589A0 (en) | 2011-07-31 |
| DK2358746T3 (da) | 2020-12-21 |
| MX359570B (es) | 2018-10-01 |
| JP2012507271A (ja) | 2012-03-29 |
| RU2650765C1 (ru) | 2018-04-17 |
| JP6329503B2 (ja) | 2018-05-23 |
| EP2358746A1 (en) | 2011-08-24 |
| CN107011425A (zh) | 2017-08-04 |
| KR20110082528A (ko) | 2011-07-19 |
| RU2011122201A (ru) | 2012-12-10 |
| CA2742241C (en) | 2019-12-10 |
| US8901076B2 (en) | 2014-12-02 |
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