RU2650765C1 - Связывающие белки, ингибирующие взаимодействие vegf-a рецептора - Google Patents

Связывающие белки, ингибирующие взаимодействие vegf-a рецептора Download PDF

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RU2650765C1
RU2650765C1 RU2015108838A RU2015108838A RU2650765C1 RU 2650765 C1 RU2650765 C1 RU 2650765C1 RU 2015108838 A RU2015108838 A RU 2015108838A RU 2015108838 A RU2015108838 A RU 2015108838A RU 2650765 C1 RU2650765 C1 RU 2650765C1
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amino acid
group
vegf
acid residue
ankyrin repeat
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Ханс Каспар БИНЦ
Патрик ФОРРЕР
Михаэль Тобиас ШТУМПП
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Молекьюлар Партнерс Аг
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    • A61P27/02Ophthalmic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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  • Ophthalmology & Optometry (AREA)
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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2015108838A 2008-11-03 2009-11-03 Связывающие белки, ингибирующие взаимодействие vegf-a рецептора RU2650765C1 (ru)

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EP08168166 2008-11-03
EP08168166.0 2008-11-03

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RU2011122201/10A RU2550258C2 (ru) 2008-11-03 2009-11-03 Связывающие белки, ингибирующие взаимодействия vegf-a рецептора

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US (2) US8901076B2 (enExample)
EP (2) EP2358746B1 (enExample)
JP (2) JP5954990B2 (enExample)
KR (1) KR101698362B1 (enExample)
CN (2) CN107011425B (enExample)
AU (1) AU2009319204B2 (enExample)
BR (1) BRPI0921469B1 (enExample)
CA (1) CA2742241C (enExample)
DK (1) DK2358746T3 (enExample)
ES (1) ES2836948T3 (enExample)
IL (1) IL212589A (enExample)
MX (2) MX359570B (enExample)
NZ (1) NZ592591A (enExample)
RU (2) RU2650765C1 (enExample)
WO (1) WO2010060748A1 (enExample)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9829494B2 (en) 2005-12-01 2017-11-28 Adrenomed Ag Methods of treatment using ADM antibodies
EP2371865B1 (en) 2006-04-07 2017-07-12 Aerpio Therapeutics, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTP-ß) and uses thereof
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制vegf-a受體交互作用的經修飾結合性蛋白質
AU2014243418B2 (en) * 2010-04-30 2016-09-22 Molecular Partners Ag Modified binding proteins inhibiting the VEGF-A receptor interaction
AU2011333666B2 (en) * 2010-11-26 2017-02-02 Molecular Partners Ag Improved capping modules for designed ankyrin repeat proteins
CA2834624A1 (en) 2011-04-29 2012-11-01 Janssen Biotech, Inc. Il4/il13 binding repeat proteins and uses
WO2012172054A1 (en) 2011-06-16 2012-12-20 Scil Proteins Gmbh Modified multimeric ubiquitin proteins binding vegf-a
CA2850830A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome and cancer
PT2780370T (pt) 2011-11-16 2019-10-30 Adrenomed Ag Anticorpo anti-adrenomedulina (adm) ou fragmento anticorpo anti-adm ou estrutura de anticorpo anti-adm não ig para utilização na terapia de uma doença aguda ou condição aguda de um paciente para estabilizar a circulação
EP2594588B1 (en) 2011-11-16 2014-05-21 AdrenoMed AG Anti-Adrenomedullin (ADM) antibody or anti-ADM antibody fragment or an anti-ADM non-Ig protein scaffold for use in therapy
ES2494190T3 (es) 2011-11-16 2014-09-15 Adrenomed Ag Anticuerpo anti-adrenomedulina (ADM) o fragmento de anticuerpo anti-ADM o andamiaje proteico sin Ig anti-ADM para reducir el riesgo de mortalidad en un paciente que padece una enfermedad crónica o aguda o un estado agudo
CN104067130B (zh) 2011-11-16 2017-02-22 斯弗因高泰克有限公司 肾上腺髓质素测定与用于确定成熟肾上腺髓质素的方法
SG10202006318TA (en) 2011-11-16 2020-08-28 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition
PT2780371T (pt) 2011-11-16 2019-01-30 Adrenomed Ag Anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou uma estrutura não ig anti-adm para a regulação do equilíbrio de fluidos num doente com uma doença aguda ou crónica
CN103308689B (zh) 2012-03-08 2017-04-12 思芬构技术有限公司 用于预测雌性对象中患上癌症的风险或诊断癌症的方法
CN103308673B (zh) 2012-03-08 2017-05-31 思芬构技术有限公司 用于预测雌性对象中发生心血管事件的风险的方法
CN103308670B (zh) 2012-03-08 2017-06-09 思芬构技术有限公司 用于预测对象患糖尿病和/或代谢综合征的风险的方法
DK2846836T3 (da) * 2012-05-07 2019-11-11 Allergan Inc Fremgangsmåde til behandling af amd hos patienter, der er refraktære overfor anti-vegf-terapi
LT3536310T (lt) 2012-06-01 2021-07-26 Novartis Ag Švirkštas
AU2013283296A1 (en) 2012-06-28 2015-02-05 Molecular Partners Ag Designed ankyrin repeat proteins binding to platelet-derived growth factor
JOP20200175A1 (ar) 2012-07-03 2017-06-16 Novartis Ag حقنة
AU2012101678B4 (en) * 2012-07-03 2013-01-24 Novartis Ag Use of device
AU2013100071C4 (en) * 2012-07-03 2013-05-02 Novartis Ag Device
JP2015528454A (ja) * 2012-08-28 2015-09-28 ノバルティス アーゲー 眼血管増殖性疾患の処置におけるvegfアンタゴニストの使用
EP3361260B1 (en) 2012-10-02 2020-06-10 sphingotec GmbH A method for diagnosing or monitoring kidney function
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
CN107991501A (zh) 2013-01-08 2018-05-04 斯弗因高泰克有限公司 生长激素的禁食水平作为心血管风险的预测标志物
CA2896370A1 (en) * 2013-02-26 2014-09-04 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
KR20150128857A (ko) * 2013-03-14 2015-11-18 알러간, 인코포레이티드 지속된-방출 전달의 조성물 및 제조 공정 동안 단백질을 안정화시키는 방법
SG11201507774YA (en) 2013-03-20 2015-10-29 Sphingotec Gmbh Adrenomedullin to guide therapy of blood pressure decline
FR3004650B1 (fr) * 2013-04-22 2015-05-29 Affilogic Composition topique comprenant un variant d'une protéine sauvage à pli-OB, ainsi que son procédé de préparation
JP6486908B2 (ja) 2013-05-31 2019-03-20 モレキュラー パートナーズ アクチェンゲゼルシャフト 肝細胞増殖因子に結合する設計アンキリン反復タンパク質
EP3010525A1 (en) 2013-06-20 2016-04-27 Novartis AG Use of a vegf antagonist in treating choroidal neovascularisation
WO2014203183A1 (en) 2013-06-20 2014-12-24 Novartis Ag Use of a vegf antagonist in treating macular edema
JP2016522248A (ja) 2013-06-20 2016-07-28 ノバルティス アーゲー ポリープ状脈絡膜血管症の治療
US20160159893A1 (en) * 2013-07-11 2016-06-09 Gabriela Burian Use of a VEGF Antagonist in Treating Retinopathy of Prematurity
WO2015004616A1 (en) * 2013-07-11 2015-01-15 Novartis Ag Use of a vegf antagonist in treating chorioretinal neovascular and permeability disorders in paediatric patients
AU2014286996A1 (en) 2013-07-12 2016-01-07 Iveric Bio, Inc. Methods for treating or preventing ophthalmological conditions
HUE047910T2 (hu) * 2013-11-05 2020-05-28 Allergan Inc Eljárás a szem állapotainak kezelésére anti-VEGF darpinnal
WO2015173260A1 (en) 2014-05-12 2015-11-19 Formycon Ag Pre-filled plastic syringe containing a vegf antagonist
US20160097781A1 (en) 2014-10-01 2016-04-07 Sphingotec Gmbh Method for stratifying a female subject for hormone replacement therapy
AU2016240220B2 (en) * 2015-04-02 2019-11-21 Molecular Partners Ag Designed ankyrin repeat domains with binding specificity for serum albumin
CA2983542A1 (en) 2015-04-24 2016-10-27 Sphingotec Gmbh A method for predicting the risk of incidence of chronic kidney disease
TWI799366B (zh) 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
BR112018009953B1 (pt) 2015-11-18 2024-03-05 Formycon Ag Seringa farmacêutica pré-preenchida esterilizada, e, kit
BR112018010005A2 (pt) 2015-11-18 2018-11-21 Formycon Ag seringa pré-carregada, e, kit
US11654046B2 (en) 2015-11-18 2023-05-23 Sio2 Medical Products, Inc. Pharmaceutical package for ophthalmic formulations
JP6953433B2 (ja) 2016-01-26 2021-10-27 フォーマイコン アーゲーFormycon Ag Vegfアンタゴニストを含む液体医薬組成物および同医薬組成物を含有する充填済みシリンジ
CN109073660B (zh) 2016-02-29 2022-10-28 麦恩泰科特有限公司 可用于治疗湿性年龄相关性黄斑变性的预测性标志物
SG11201809252YA (en) 2016-04-21 2018-11-29 Sphingotec Therapeutics Gmbh Methods for determining dpp3 and therapeutic methods
MA45493A (fr) 2016-06-27 2019-05-01 Aicuris Anti Infective Cures Gmbh Inhibiteurs d'entrée de hcmv.
SG11201900133WA (en) 2016-07-08 2019-02-27 Sphingotec Gmbh Adrenomedullin for assessing congestion in a subject with acute heart failure
JP7107914B2 (ja) 2016-07-20 2022-07-27 アイポイント ファーマシューティカルズ, インコーポレイテッド VE-PTP(HPTP-β)を標的化するヒト化モノクローナル抗体
AR109680A1 (es) 2016-09-22 2019-01-09 Molecular Partners Ag Proteínas recombinantes y sus usos
EP3309550A1 (en) 2016-10-12 2018-04-18 sphingotec GmbH Method for the detection of apolipoprotein e4
EP3339324A1 (en) 2016-12-22 2018-06-27 sphingotec GmbH Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof
MY208219A (en) 2016-12-16 2025-04-24 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof
WO2018215580A1 (en) 2017-05-24 2018-11-29 Formycon Ag Method for sterilizing prefilled plastic syringes containing a vegf antagonist
US20200171244A1 (en) 2017-05-24 2020-06-04 Sio2 Medical Products, Inc. Sterilizable pharmaceutical package for ophthalmic formulations
WO2018217995A1 (en) 2017-05-24 2018-11-29 Formycon Ag Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
JP7271442B2 (ja) 2017-05-30 2023-05-11 シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング 腎機能を診断またはモニターする方法、または腎機能障害を診断することを補助する方法
TW201904610A (zh) 2017-06-14 2019-02-01 德商拜耳製藥公司 用於治療新生血管型青光眼之非抗體vegf拮抗劑
WO2019020777A1 (en) 2017-07-26 2019-01-31 Formycon Ag LIQUID FORMULATION OF A VEGF ANTAGONIST
SG11202001420VA (en) * 2017-08-18 2020-03-30 Cambridge Entpr Ltd Modular binding proteins
MY204700A (en) 2017-09-25 2024-09-10 Adrenomed Ag Anti-adrenomedullin (adm) binder for use in therapy or prevention of symptoms of illness
SG11202002268XA (en) 2017-10-18 2020-04-29 Adrenomed Ag Therapy monitoring under treatment with an anti-adrenomedullin (adm) binder
SG11202002391PA (en) 2017-10-24 2020-04-29 Sphingotec Gmbh Selenoprotein p for prediction of a first cardiovascular event
IL274009B2 (en) 2017-10-25 2025-01-01 4TEEN4 Pharmaceuticals GmbH DDP3-bound targeting and binding to specific epitopes of DDP3 and their use for the prevention or treatment of diseases/acute conditions associated with acidosis
MX421834B (es) 2018-02-08 2025-03-14 Sphingotec Gmbh Adrenomedulina (adm) para el diagnostico y/o prediccion de demencia y un aglutinante de anti-adrenomedulina para usarse en la terapia o prevencion de demencia
EP3569614A1 (en) 2018-05-18 2019-11-20 Julius-Maximilians-Universität Würzburg Compounds and methods for the immobilization of myostatin-inhibitors on the extracellular matrix by transglutaminase
EP3586865A1 (en) 2018-06-21 2020-01-01 Charité - Universitätsmedizin Berlin Complement anaphylatoxin binders and their use in treatment of a subject having an ocular wound and/or fibrosis
CN113164597B (zh) 2018-09-24 2025-02-28 视点制药公司 靶向HPTP-β(VE-PTP)和VEGF的多特异性抗体
SG11202105176QA (en) 2018-12-20 2021-06-29 Sphingotec Gmbh Selenoprotein p in heart failure
WO2020128039A2 (en) 2018-12-21 2020-06-25 4TEEN4 Pharmaceuticals GmbH Therapy guidance and/or therapy monitoring for a treatment with angiotensin-receptor-agonist and/or a precursor thereof
JP2022535564A (ja) 2019-06-04 2022-08-09 モレキュラー パートナーズ アクチェンゲゼルシャフト 多選択性タンパク質
BR112022001417A2 (pt) 2019-08-15 2022-05-24 Sphingotec Gmbh Método para diagnóstico ou monitoramento de função renal ou diagnóstico de disfunção renal em pacientes pediátricos
JP2022546061A (ja) 2019-08-30 2022-11-02 4ティーン4 ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング ショック症治療のための治療法の誘導および/または治療法の監視
EP4073091A1 (en) 2019-12-11 2022-10-19 Molecular Partners AG Designed ankyrin repeat domains with altered surface residues
EP3871689A1 (en) 2020-02-26 2021-09-01 sphingotec GmbH Anti-adm-antibodies binding to the free n-terminus for accelerated transition of adm-gly to bio-adm in patients with adm-gly/ bio-adm ratio above a threshold and combination with vitamin c
US20230193348A1 (en) 2020-02-27 2023-06-22 4TEEN4 Pharmaceuticals GmbH Dpp3 for therapy guidance, monitoring and stratification of nt-adm antibodies in patients with shock
KR20220145897A (ko) 2020-02-27 2022-10-31 아드레노메드 아게 쇼크의 치료 또는 예방에 사용하기 위한 항-아드레노메둘린 (adm) 항체 또는 항-adm 항체 단편 또는 항-adm 비-ig 스캐폴드
US20230250166A1 (en) 2020-02-27 2023-08-10 Adrenomed Ag Anti-adrenomedullin (adm) binder for use in therapy of patients in shock
JP2023518731A (ja) 2020-03-16 2023-05-08 4ティーン4 ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング コロナウイルスに感染した患者におけるdpp3
EP3922993A1 (en) 2020-06-12 2021-12-15 4TEEN4 Pharmaceuticals GmbH Dpp3 in patients infected with coronavirus
JP2023517717A (ja) 2020-03-16 2023-04-26 シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング コロナウイルスに感染した患者におけるプロアドレノメデュリンまたはそのフラグメント、およびアドレノメデュリンに対する結合剤による治療
CN115916815A (zh) 2020-05-06 2023-04-04 分子合作伙伴股份公司 新型锚蛋白重复结合蛋白及其用途
BR112022023049A2 (pt) 2020-05-14 2022-12-20 Molecular Partners Ag Proteínas multiespecíficas
EP4023218A1 (en) 2020-12-02 2022-07-06 S-Form Pharma Combination therapy for patients having acute and/or persistent dyspnea
EP4263607A1 (en) 2020-12-16 2023-10-25 Molecular Partners AG Novel slow-release prodrugs
AU2022232216A1 (en) 2021-03-09 2023-10-05 Molecular Partners Ag Protease cleavable prodrugs
US20240150475A1 (en) 2021-03-09 2024-05-09 Molecular Partners Ag Novel darpin based cd123 engagers
KR20230155464A (ko) 2021-03-09 2023-11-10 몰리큘라 파트너스 아게 신규한 DARPin-기반 다중특이성 T-세포 인게이저
WO2022190010A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based cd33 engagers
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
US20240272178A1 (en) 2021-06-18 2024-08-15 Sphingotec Gmbh A method for predicting sepsis and septic shock
EP4363859A1 (en) 2021-06-29 2024-05-08 berYsol GmbH Composite biomarker for the identification of selenium deficiency in a bodily fluid
EP4145456A1 (en) 2021-09-06 2023-03-08 Bayer AG Prediction of a change related to a macular fluid
WO2023110983A1 (en) 2021-12-14 2023-06-22 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
AU2023233838A1 (en) 2022-03-15 2024-09-26 Adrenomed Ag Stable aqueous formulation of an anti-adrenomedullin (adm) antibody or anti-adm antibody fragment
EP4562035A1 (en) 2022-07-29 2025-06-04 AdrenoMed AG Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock
JP2025527173A (ja) 2022-07-29 2025-08-20 4ティーン4 ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 敗血性ショックを有する患者におけるdpp3の増加の予測
WO2024028278A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
WO2024059686A2 (en) * 2022-09-15 2024-03-21 The Regents Of The University Of California Darpin backbones and rigidified electron microscopy imaging scaffolds
WO2024126793A1 (en) 2022-12-15 2024-06-20 4TEEN4 Pharmaceuticals GmbH Dpp3 inhibitor for improvement of pulmonary function in critically ill patients
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs
CN120731367A (zh) 2023-03-17 2025-09-30 Pam治疗诊断有限公司 肽基甘氨酸α-酰胺化单加氧酶(PAM)的测定方法及其诊断用途
CN120857945A (zh) 2023-03-29 2025-10-28 4Teen4制药有限公司 用于在血压下降的危重病患者中保护心肌和预防心肌损伤的dpp3抑制剂
WO2025068313A1 (en) 2023-09-25 2025-04-03 Sphingotec Gmbh A method for early diagnosis, early prediction, monitoring or prediction of severity of reduced graft function in a kidney transplantation patient
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
WO2025229075A1 (en) 2024-05-03 2025-11-06 Sphingotec Gmbh A method for the specific determination of proenkephalin fragment 119-159
WO2025248139A1 (en) 2024-05-31 2025-12-04 4TEEN4 Pharmaceuticals GmbH Use of adrenomedullin or fragments thereof in the treatment of a patient in need thereof
EP4675277A1 (en) 2024-07-05 2026-01-07 Predemtec AG A method for diagnosing alzheimer´s disease or determining the risk of suffering from alzheimer´s disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020565A2 (en) * 2000-09-08 2002-03-14 Universität Zürich Collections of repeat proteins comprising repeat modules
WO2005087797A1 (en) * 2004-03-09 2005-09-22 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
RU2299208C2 (ru) * 2001-05-08 2007-05-20 Шеринг Акциенгезельшафт Антраниламидпиридинамиды избирательного действия в качестве ингибиторов vegfr-2 и vegfr-3

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1026240A3 (en) 1988-09-02 2004-04-07 Dyax Corp. Generation and selection of recombinant varied binding proteins
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5348867A (en) 1991-11-15 1994-09-20 George Georgiou Expression of proteins on bacterial surface
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
ES2236634T3 (es) 1997-04-07 2005-07-16 Genentech, Inc. Anticuerpos anti-vegf.
KR100794454B1 (ko) 1997-04-07 2008-01-16 제넨테크, 인크. 항-vegf 항체
CA2289691C (en) 1997-04-23 2008-01-15 Andreas Pluckthun Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules
US6416950B1 (en) 1998-12-02 2002-07-09 Phylos, Inc. DNA-protein fusions and uses thereof
US7087411B2 (en) * 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
BRPI0011407B8 (pt) 1999-06-08 2021-05-25 Regeneron Pharma molécula de ácido nucléico quimérica, polipeptídeo de fusão, vetor de expressão, sistema de vetor hospedeiro, e, métodos de produzir um polipeptídeo de fusão
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
AU2004296376B2 (en) 2003-12-05 2010-03-04 Bristol-Myers Squibb Company Inhibitors of type 2 vascular endothelial growth factor receptors
WO2006050984A2 (en) * 2004-11-12 2006-05-18 Bayer Schering Pharma Aktiengesellschaft Recombinant newcastle disease virus
CA2995971A1 (en) * 2005-03-25 2006-10-05 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations
ES2335136T3 (es) 2005-07-08 2010-03-22 University Of Zurich Expresion fagica mediante translocacion cotraduccional de polipeptidos de fusion.
EP2121743B1 (en) * 2006-11-22 2015-06-03 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
BRPI0806414A2 (pt) * 2007-02-01 2011-09-06 Genentech Inc método para tratamento de tumor
ATE516814T1 (de) 2007-02-02 2011-08-15 Bristol Myers Squibb Co 10fn3 domain zur behandlung von krankheiten begleitet von unerwünschter angiogenese

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020565A2 (en) * 2000-09-08 2002-03-14 Universität Zürich Collections of repeat proteins comprising repeat modules
RU2299208C2 (ru) * 2001-05-08 2007-05-20 Шеринг Акциенгезельшафт Антраниламидпиридинамиды избирательного действия в качестве ингибиторов vegfr-2 и vegfr-3
WO2005087797A1 (en) * 2004-03-09 2005-09-22 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRADLEY C.M. et al. Limits of cooperativity in a structurally modular protein: response of the Notch ankyrin domain to analogous alanine substitutions in each repeat, J. Mol. Biol., 2002, v. 324, p. 373-386. *
INOKI I. et al. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis, The FASEB Journal, 2002, v. 16, p. 219-221. *
INOKI I. et al. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis, The FASEB Journal, 2002, v. 16, p. 219-221. STUMPP M.T. et al. DARPins: A new generation of protein therapeutics, Drug Discovery Today, 2008, v. 13, n. 15/16, p.695-701. *
STUMPP M.T. et al. DARPins: A new generation of protein therapeutics, Drug Discovery Today, 2008, v. 13, n. 15/16, p.695-701. *

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