DK2358746T3 - Bindingsproteiner til inhibering af vegf-a-receptorinteraktionen - Google Patents
Bindingsproteiner til inhibering af vegf-a-receptorinteraktionen Download PDFInfo
- Publication number
- DK2358746T3 DK2358746T3 DK09756279.7T DK09756279T DK2358746T3 DK 2358746 T3 DK2358746 T3 DK 2358746T3 DK 09756279 T DK09756279 T DK 09756279T DK 2358746 T3 DK2358746 T3 DK 2358746T3
- Authority
- DK
- Denmark
- Prior art keywords
- vegf
- inhibit
- binding proteins
- receptor interaction
- receptor
- Prior art date
Links
- 230000010799 Receptor Interactions Effects 0.000 title 1
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 title 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 title 1
- 102000023732 binding proteins Human genes 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08168166 | 2008-11-03 | ||
| PCT/EP2009/064483 WO2010060748A1 (en) | 2008-11-03 | 2009-11-03 | Binding proteins inhibiting the vegf-a receptor interaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2358746T3 true DK2358746T3 (da) | 2020-12-21 |
Family
ID=40149742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09756279.7T DK2358746T3 (da) | 2008-11-03 | 2009-11-03 | Bindingsproteiner til inhibering af vegf-a-receptorinteraktionen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8901076B2 (enExample) |
| EP (2) | EP2358746B1 (enExample) |
| JP (2) | JP5954990B2 (enExample) |
| KR (1) | KR101698362B1 (enExample) |
| CN (2) | CN107011425B (enExample) |
| AU (1) | AU2009319204B2 (enExample) |
| BR (1) | BRPI0921469B1 (enExample) |
| CA (1) | CA2742241C (enExample) |
| DK (1) | DK2358746T3 (enExample) |
| ES (1) | ES2836948T3 (enExample) |
| IL (1) | IL212589A (enExample) |
| MX (2) | MX2011004649A (enExample) |
| NZ (1) | NZ592591A (enExample) |
| RU (2) | RU2650765C1 (enExample) |
| WO (1) | WO2010060748A1 (enExample) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9829494B2 (en) | 2005-12-01 | 2017-11-28 | Adrenomed Ag | Methods of treatment using ADM antibodies |
| EP3252079B8 (en) | 2006-04-07 | 2020-09-09 | Aerpio Therapeutics LLC | Antibodies that bind human protein tyrosine phosphatase beta (hptp-beta) and uses thereof |
| TWI510246B (zh) * | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| AU2014243418B2 (en) * | 2010-04-30 | 2016-09-22 | Molecular Partners Ag | Modified binding proteins inhibiting the VEGF-A receptor interaction |
| EP2643349B1 (en) | 2010-11-26 | 2019-09-04 | Molecular Partners AG | Designed repeat proteins binding to serum albumin |
| KR20140039203A (ko) | 2011-04-29 | 2014-04-01 | 얀센 바이오테크 인코포레이티드 | Il4/il13 결합 반복 단백질 및 용도 |
| WO2012172054A1 (en) | 2011-06-16 | 2012-12-20 | Scil Proteins Gmbh | Modified multimeric ubiquitin proteins binding vegf-a |
| CN104039351A (zh) | 2011-10-13 | 2014-09-10 | 阿尔皮奥治疗学股份有限公司 | 用于治疗血管渗漏综合征和癌症的方法 |
| PL2594587T3 (pl) | 2011-11-16 | 2014-11-28 | Adrenomed Ag | Przeciwciało przeciwko adrenomedulinie (ADM) lub fragment przeciwciała anty-ADM lub szkielet białkowy niestanowiący Ig anty-ADM do zmniejszenia ryzyka śmierci u pacjenta cierpiącego na chorobę przewlekłą lub ostrą lub stan ostry |
| HRP20170427T1 (hr) | 2011-11-16 | 2017-06-16 | Sphingotec Gmbh | Testovi na adrenomedulin i postupci određivanja zrelog adrenomedulina |
| SG10201802054TA (en) | 2011-11-16 | 2018-05-30 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease |
| NZ624873A (en) | 2011-11-16 | 2016-07-29 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition |
| KR102249078B1 (ko) | 2011-11-16 | 2021-05-10 | 아드레노메드 아게 | 요법에 사용하기 위한 항-아드레노메둘린 (adm) 항체 또는 항-adm 항체 단편 또는 항-adm 비-ig 스캐폴드 |
| ES2751492T3 (es) | 2011-11-16 | 2020-03-31 | Adrenomed Ag | Anticuerpo anti-adrenomedulina (ADM) o fragmento de anticuerpo anti-ADM o armazón no Ig anti-ADM para uso en la terapia de una enfermedad aguda o una afección aguda de un paciente para estabilizar la circulación |
| CN103308670B (zh) | 2012-03-08 | 2017-06-09 | 思芬构技术有限公司 | 用于预测对象患糖尿病和/或代谢综合征的风险的方法 |
| CN103308673B (zh) | 2012-03-08 | 2017-05-31 | 思芬构技术有限公司 | 用于预测雌性对象中发生心血管事件的风险的方法 |
| CN103308689B (zh) | 2012-03-08 | 2017-04-12 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
| WO2013169614A1 (en) * | 2012-05-07 | 2013-11-14 | Allergan, Inc. | Method of treating amd in patients refractory to anti-vegf therapy |
| EA033161B1 (ru) | 2012-06-01 | 2019-09-30 | Новартис Аг | Шприц |
| WO2014001442A1 (en) * | 2012-06-28 | 2014-01-03 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| AU2012101677B4 (en) | 2012-07-03 | 2012-12-20 | Novartis Ag | Device |
| AU2013100071C4 (en) * | 2012-07-03 | 2013-05-02 | Novartis Ag | Device |
| DE202013000688U1 (de) | 2012-07-03 | 2013-03-05 | Novartis Ag | Glas-Spritze |
| JP2015528454A (ja) * | 2012-08-28 | 2015-09-28 | ノバルティス アーゲー | 眼血管増殖性疾患の処置におけるｖｅｇｆアンタゴニストの使用 |
| DK2904403T3 (en) | 2012-10-02 | 2018-07-16 | Sphingotec Gmbh | PROCEDURE FOR DIAGNOSTICATION OR MONITORING OF Kidney Function or Diagnosis of Kidney Function |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| RU2677895C2 (ru) | 2013-01-08 | 2019-01-22 | Сфинготек Гмбх | Уровни гормона роста натощак в качестве прогностического маркера сердечно-сосудистого риска |
| CN110845618A (zh) * | 2013-02-26 | 2020-02-28 | 罗切格利卡特公司 | 双特异性t细胞活化抗原结合分子 |
| JP6649246B2 (ja) * | 2013-03-14 | 2020-02-19 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | タンパク質の徐放性送達の組成物及び製造プロセス中のタンパク質の安定化方法 |
| SG10201800309SA (en) | 2013-03-20 | 2018-02-27 | Sphingotec Gmbh | Adrenomedullin to guide therapy of blood pressure decline |
| FR3004650B1 (fr) * | 2013-04-22 | 2015-05-29 | Affilogic | Composition topique comprenant un variant d'une protéine sauvage à pli-OB, ainsi que son procédé de préparation |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
| WO2014203181A1 (en) | 2013-06-20 | 2014-12-24 | Novartis Ag | Treatment of polypoidal choroidal vasculopathy |
| EP3010526A1 (en) | 2013-06-20 | 2016-04-27 | Novartis AG | Use of a vegf antagonist in treating macular edema |
| EP3010525A1 (en) | 2013-06-20 | 2016-04-27 | Novartis AG | Use of a vegf antagonist in treating choroidal neovascularisation |
| US20160168240A1 (en) | 2013-07-11 | 2016-06-16 | Sergey AKSENOV | Use of vegf antagonist in treating chorioretinal neovascular and permeability disorders in paediatric patients |
| RU2676303C2 (ru) * | 2013-07-11 | 2018-12-27 | Новартис Аг | Использование антагониста vegf для лечения ретролентальной фиброплазии |
| EA201690212A8 (ru) | 2013-07-12 | 2016-08-31 | Офтотек Корпорейшн | Способы лечения или профилактики офтальмологических патологических состояний |
| EP3628324A1 (en) * | 2013-11-05 | 2020-04-01 | Allergan, Inc. | Method of treating conditions of the eye with an anti-vegf darpin |
| EP3828202A1 (en) | 2014-05-12 | 2021-06-02 | Formycon AG | Pre-filled plastic syringe containing a vegf antagonist |
| EP3002589A1 (en) | 2014-10-01 | 2016-04-06 | sphingotec GmbH | A method for stratifying a female subject for hormone replacement therapy |
| US9458211B1 (en) | 2015-04-02 | 2016-10-04 | Molecular Partners Ag | Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains |
| WO2016170023A1 (en) | 2015-04-24 | 2016-10-27 | Sphingotec Gmbh | A method for predicting the risk of incidence of chronic kidney disease |
| TWI799366B (zh) * | 2015-09-15 | 2023-04-21 | 美商建南德克公司 | 胱胺酸結骨架平臺 |
| RU2751510C2 (ru) | 2015-11-18 | 2021-07-14 | Сио2 Медикал Продактс, Инк. | Фармацевтическая упаковка для офтальмологических составов |
| WO2018218013A2 (en) | 2017-05-24 | 2018-11-29 | Sio2 Medical Products, Inc. | Sterilizable pharmaceutical package for ophthalmic formulations |
| US20180326126A1 (en) | 2015-11-18 | 2018-11-15 | Formycon Ag | Pre-filled plastic syringe containing a vegf antagonist |
| CN108883172A (zh) | 2015-11-18 | 2018-11-23 | 福迈康股份公司 | 包含vegf拮抗剂的液体配制品的预填充药物包装 |
| AU2017213103B2 (en) | 2016-01-26 | 2022-08-11 | Formycon Ag | Liquid formulation of a VEGF antagonist |
| CN109073660B (zh) | 2016-02-29 | 2022-10-28 | 麦恩泰科特有限公司 | 可用于治疗湿性年龄相关性黄斑变性的预测性标志物 |
| CH713803B1 (de) | 2016-04-21 | 2023-08-15 | 4TEEN4 Pharmaceuticals GmbH | Verfahren zur Diagnose durch Bestimmung von DPP3, Hemmer der Aktivität von DPP3 und Zusammensetzung mit einem Hemmer. |
| EP3474887A1 (en) | 2016-06-27 | 2019-05-01 | AiCuris Anti-infective Cures GmbH | Hcmv entry inhibitors |
| JP7191813B2 (ja) | 2016-07-08 | 2022-12-19 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 急性心不全に罹患している対象におけるうっ血を評価するためのアドレノメデュリン |
| WO2018017714A1 (en) | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) |
| AR109680A1 (es) | 2016-09-22 | 2019-01-09 | Molecular Partners Ag | Proteínas recombinantes y sus usos |
| EP3309550A1 (en) | 2016-10-12 | 2018-04-18 | sphingotec GmbH | Method for the detection of apolipoprotein e4 |
| MX2019007107A (es) | 2016-12-16 | 2019-10-21 | Adrenomed Ag | Anticuerpo anti-adrenomedulina (adm) o fragmento de anticuerpo anti-adm o supercontigo sin ig anti-adm para su uso en intervencion y terapia de congestion en un paciente con necesidad del mismo. |
| EP3339324A1 (en) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof |
| WO2018217995A1 (en) | 2017-05-24 | 2018-11-29 | Formycon Ag | Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist |
| WO2018215580A1 (en) | 2017-05-24 | 2018-11-29 | Formycon Ag | Method for sterilizing prefilled plastic syringes containing a vegf antagonist |
| BR112019024966A2 (pt) | 2017-05-30 | 2020-06-23 | Sphingotec Gmbh | Método para diagnosticar ou monitorar a função renal ou diagnosticar a disfunção renal |
| TW201904610A (zh) | 2017-06-14 | 2019-02-01 | 德商拜耳製藥公司 | 用於治療新生血管型青光眼之非抗體vegf拮抗劑 |
| WO2019020777A1 (en) | 2017-07-26 | 2019-01-31 | Formycon Ag | LIQUID FORMULATION OF A VEGF ANTAGONIST |
| CN111225976A (zh) * | 2017-08-18 | 2020-06-02 | 剑桥企业有限公司 | 模块化结合蛋白 |
| WO2019057992A2 (en) | 2017-09-25 | 2019-03-28 | Adrenomed Ag | ANTI-ADRENOMEDULIN (ADM) BINDER FOR USE IN TREATING OR PREVENTING THE SYMPTOMS OF A DISEASE |
| BR112020005682A2 (pt) | 2017-10-18 | 2020-10-20 | Adrenomed Ag | monitoração de terapia sob tratamento com um aglutinante de antiadrenomedulina (adm) |
| EP3701266A1 (en) | 2017-10-24 | 2020-09-02 | sphingotec GmbH | Selenoprotein p for prediction of a first cardiovascular event |
| MY202502A (en) | 2017-10-25 | 2024-05-01 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 binder directed to and binding to specific dpp3-epitopes and its use in the prevention or treatment of diseases / acute conditions that are associated with oxidative stress |
| EP3749959A1 (en) | 2018-02-08 | 2020-12-16 | sphingotec GmbH | Adrenomedullin (adm) for diagnosis and/or prediction of dementia and anti-adrenomedullin binder for use in therapy or prevention of dementia |
| EP3569614A1 (en) | 2018-05-18 | 2019-11-20 | Julius-Maximilians-Universität Würzburg | Compounds and methods for the immobilization of myostatin-inhibitors on the extracellular matrix by transglutaminase |
| EP3586865A1 (en) | 2018-06-21 | 2020-01-01 | Charité - Universitätsmedizin Berlin | Complement anaphylatoxin binders and their use in treatment of a subject having an ocular wound and/or fibrosis |
| CN120058958A (zh) | 2018-09-24 | 2025-05-30 | 视点制药公司 | 靶向HPTP-β（VE-PTP）和VEGF的多特异性抗体 |
| AU2019408553A1 (en) | 2018-12-20 | 2021-06-17 | Sphingotec Gmbh | Selenoprotein P in heart failure |
| WO2020128039A2 (en) | 2018-12-21 | 2020-06-25 | 4TEEN4 Pharmaceuticals GmbH | Therapy guidance and/or therapy monitoring for a treatment with angiotensin-receptor-agonist and/or a precursor thereof |
| AU2020289080A1 (en) | 2019-06-04 | 2021-12-23 | Molecular Partners Ag | Multispecific proteins |
| EP4014049A1 (en) | 2019-08-15 | 2022-06-22 | sphingotec GmbH | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction in pediatric patients |
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- 2009-11-03 JP JP2011533752A patent/JP5954990B2/ja active Active
- 2009-11-03 CN CN201710092752.9A patent/CN107011425B/zh active Active
- 2009-11-03 KR KR1020117009012A patent/KR101698362B1/ko active Active
- 2009-11-03 DK DK09756279.7T patent/DK2358746T3/da active
- 2009-11-03 MX MX2011004649A patent/MX2011004649A/es unknown
- 2009-11-03 US US13/126,821 patent/US8901076B2/en active Active
- 2009-11-03 ES ES09756279T patent/ES2836948T3/es active Active
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- 2009-11-03 RU RU2015108838A patent/RU2650765C1/ru active
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- 2009-11-03 EP EP20196328.7A patent/EP3785735A1/en not_active Withdrawn
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|---|---|
| US20150344539A1 (en) | 2015-12-03 |
| KR101698362B1 (ko) | 2017-01-20 |
| CN107011425A (zh) | 2017-08-04 |
| EP3785735A1 (en) | 2021-03-03 |
| CA2742241A1 (en) | 2010-06-03 |
| MX2011004649A (es) | 2011-05-30 |
| AU2009319204B2 (en) | 2014-11-13 |
| MX359570B (es) | 2018-10-01 |
| RU2011122201A (ru) | 2012-12-10 |
| CN102272148A (zh) | 2011-12-07 |
| BRPI0921469A2 (pt) | 2016-01-12 |
| IL212589A (en) | 2017-01-31 |
| BRPI0921469B1 (pt) | 2022-01-18 |
| RU2650765C1 (ru) | 2018-04-17 |
| WO2010060748A1 (en) | 2010-06-03 |
| CA2742241C (en) | 2019-12-10 |
| IL212589A0 (en) | 2011-07-31 |
| AU2009319204A1 (en) | 2010-06-03 |
| US8901076B2 (en) | 2014-12-02 |
| EP2358746B1 (en) | 2020-09-16 |
| KR20110082528A (ko) | 2011-07-19 |
| RU2550258C2 (ru) | 2015-05-10 |
| ES2836948T3 (es) | 2021-06-28 |
| EP2358746A1 (en) | 2011-08-24 |
| NZ592591A (en) | 2012-04-27 |
| JP2015133978A (ja) | 2015-07-27 |
| US20110207668A1 (en) | 2011-08-25 |
| JP2012507271A (ja) | 2012-03-29 |
| JP5954990B2 (ja) | 2016-07-20 |
| JP6329503B2 (ja) | 2018-05-23 |
| CN107011425B (zh) | 2021-01-01 |
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