ES2826896T3 - Método para preparar vesículas con gradiente de pH transmembrana - Google Patents

Método para preparar vesículas con gradiente de pH transmembrana Download PDF

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Publication number
ES2826896T3
ES2826896T3 ES16724597T ES16724597T ES2826896T3 ES 2826896 T3 ES2826896 T3 ES 2826896T3 ES 16724597 T ES16724597 T ES 16724597T ES 16724597 T ES16724597 T ES 16724597T ES 2826896 T3 ES2826896 T3 ES 2826896T3
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ES
Spain
Prior art keywords
vesicles
mosm
buffer
osmolarity
aqueous medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16724597T
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English (en)
Spanish (es)
Inventor
Jean-Christophe Leroux
Vincent Forster
Valentina Agostoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Versantis AG
Original Assignee
Versantis AG
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Publication of ES2826896T3 publication Critical patent/ES2826896T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES16724597T 2015-05-04 2016-05-03 Método para preparar vesículas con gradiente de pH transmembrana Active ES2826896T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15166247 2015-05-04
PCT/EP2016/059912 WO2016177741A1 (en) 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles

Publications (1)

Publication Number Publication Date
ES2826896T3 true ES2826896T3 (es) 2021-05-19

Family

ID=53052718

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16724597T Active ES2826896T3 (es) 2015-05-04 2016-05-03 Método para preparar vesículas con gradiente de pH transmembrana

Country Status (11)

Country Link
US (2) US11376218B2 (cg-RX-API-DMAC7.html)
EP (1) EP3291797B1 (cg-RX-API-DMAC7.html)
JP (1) JP6715265B2 (cg-RX-API-DMAC7.html)
CN (1) CN107750156B (cg-RX-API-DMAC7.html)
AU (1) AU2016256979B2 (cg-RX-API-DMAC7.html)
DK (1) DK3291797T3 (cg-RX-API-DMAC7.html)
ES (1) ES2826896T3 (cg-RX-API-DMAC7.html)
MX (1) MX381655B (cg-RX-API-DMAC7.html)
PT (1) PT3291797T (cg-RX-API-DMAC7.html)
RU (1) RU2717824C2 (cg-RX-API-DMAC7.html)
WO (1) WO2016177741A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX381655B (es) * 2015-05-04 2025-03-13 Versantis AG Metodo para preparar vesiculas con gradiente de ph de transmembrana.
EP4247366A1 (en) 2020-11-17 2023-09-27 Genfit Methods of treatment of liver failure
WO2024105101A1 (en) 2022-11-16 2024-05-23 Genfit Use of transmembrane ph gradient liposomes for treating hyperammonemic crisis associated with inborn errors of metabolism

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Also Published As

Publication number Publication date
US11376218B2 (en) 2022-07-05
JP6715265B2 (ja) 2020-07-01
CN107750156A (zh) 2018-03-02
AU2016256979B2 (en) 2021-01-28
US20220287971A1 (en) 2022-09-15
AU2016256979A1 (en) 2017-12-07
MX2017014130A (es) 2018-07-06
RU2717824C2 (ru) 2020-03-26
WO2016177741A1 (en) 2016-11-10
RU2017141919A3 (cg-RX-API-DMAC7.html) 2019-09-20
RU2017141919A (ru) 2019-06-04
CN107750156B (zh) 2020-08-21
PT3291797T (pt) 2020-10-19
BR112017023578A2 (pt) 2018-09-04
CA2987844A1 (en) 2016-11-10
EP3291797A1 (en) 2018-03-14
US20180104189A1 (en) 2018-04-19
EP3291797B1 (en) 2020-09-02
US12427112B2 (en) 2025-09-30
DK3291797T3 (da) 2020-09-21
JP2018519370A (ja) 2018-07-19
HK1250663A1 (en) 2019-01-11
MX381655B (es) 2025-03-13

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