ES2824452T3 - Métodos para producir coloides de hidroxido de hierro férrico modificados con un ligando de carboxilato y composiciones y usos relacionados - Google Patents
Métodos para producir coloides de hidroxido de hierro férrico modificados con un ligando de carboxilato y composiciones y usos relacionados Download PDFInfo
- Publication number
- ES2824452T3 ES2824452T3 ES16778044T ES16778044T ES2824452T3 ES 2824452 T3 ES2824452 T3 ES 2824452T3 ES 16778044 T ES16778044 T ES 16778044T ES 16778044 T ES16778044 T ES 16778044T ES 2824452 T3 ES2824452 T3 ES 2824452T3
- Authority
- ES
- Spain
- Prior art keywords
- ferric iron
- modified
- ligand
- carboxylate
- iron hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000014413 iron hydroxide Nutrition 0.000 title claims abstract 36
- 239000000203 mixture Substances 0.000 title claims abstract 14
- 238000000034 method Methods 0.000 title claims 18
- -1 Carboxylate Ligand-Modified Ferric Iron Chemical class 0.000 title claims 5
- 239000000084 colloidal system Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 claims abstract 58
- 150000007942 carboxylates Chemical class 0.000 claims abstract 42
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims abstract 41
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract 31
- 238000009472 formulation Methods 0.000 claims abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 5
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 5
- 239000002904 solvent Substances 0.000 claims abstract 5
- 239000000725 suspension Substances 0.000 claims abstract 5
- 238000001035 drying Methods 0.000 claims abstract 3
- 239000007790 solid phase Substances 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 19
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 11
- 229940095064 tartrate Drugs 0.000 claims 10
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 8
- 229910052742 iron Inorganic materials 0.000 claims 8
- 239000000463 material Substances 0.000 claims 8
- 239000002775 capsule Substances 0.000 claims 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 5
- 239000003826 tablet Substances 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 239000013589 supplement Substances 0.000 claims 4
- 206010022971 Iron Deficiencies Diseases 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 208000030760 Anaemia of chronic disease Diseases 0.000 claims 1
- 208000017667 Chronic Disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 208000022400 anemia due to chronic disease Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000006651 lactation Effects 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Iron (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1517893.2A GB201517893D0 (en) | 2015-10-09 | 2015-10-09 | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids |
| PCT/EP2016/074022 WO2017060441A1 (en) | 2015-10-09 | 2016-10-07 | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids and related compositions and uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2824452T3 true ES2824452T3 (es) | 2021-05-12 |
Family
ID=55130824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16778044T Active ES2824452T3 (es) | 2015-10-09 | 2016-10-07 | Métodos para producir coloides de hidroxido de hierro férrico modificados con un ligando de carboxilato y composiciones y usos relacionados |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10722459B2 (enExample) |
| EP (1) | EP3359519B1 (enExample) |
| JP (1) | JP7008624B2 (enExample) |
| CN (1) | CN108430964B (enExample) |
| AU (1) | AU2016333725B2 (enExample) |
| BR (1) | BR112018007098B1 (enExample) |
| CA (1) | CA3000589C (enExample) |
| DK (1) | DK3359519T3 (enExample) |
| EA (1) | EA035547B1 (enExample) |
| ES (1) | ES2824452T3 (enExample) |
| GB (1) | GB201517893D0 (enExample) |
| HU (1) | HUE051502T2 (enExample) |
| MX (1) | MX2018004113A (enExample) |
| PL (1) | PL3359519T3 (enExample) |
| PT (1) | PT3359519T (enExample) |
| SG (1) | SG11201802770WA (enExample) |
| SI (1) | SI3359519T1 (enExample) |
| WO (1) | WO2017060441A1 (enExample) |
| ZA (1) | ZA201802192B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11560339B2 (en) | 2019-05-30 | 2023-01-24 | Koch Agronomie Services, LLC | Micronutrient foliar solutions |
| GB202005054D0 (en) | 2020-04-06 | 2020-05-20 | Nemysis Ltd | Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases |
| CN115196684B (zh) * | 2022-07-25 | 2024-10-01 | 武汉海斯普林科技发展有限公司 | 一种高活性高纯氢氧化铁、制备方法及在合成对甲基苯磺酸铁中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3076798A (en) | 1961-02-23 | 1963-02-05 | Hausmann Lab Ltd | Process for preparing a ferric hydroxide polymaltose complex |
| US3821192A (en) | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| CN1124757A (zh) * | 1994-12-31 | 1996-06-19 | 温固 | 速溶多羟基混合金属盐正电固溶胶制备方法 |
| CN1121349C (zh) * | 2001-10-30 | 2003-09-17 | 李国栋 | 一种无团聚氧化锌纳米粉体制造方法 |
| US7994217B2 (en) | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
| GB0211500D0 (en) | 2002-05-18 | 2002-06-26 | Vitra Pharmaceuticals Ltd | Method of forming iron hydroxypyrone compounds |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US8093423B2 (en) | 2003-02-19 | 2012-01-10 | Globoasia, Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and method of making same |
| TWI335218B (en) | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US7964568B2 (en) | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| US7179939B2 (en) | 2004-03-16 | 2007-02-20 | Navinta Llc | Sodium ferric gluconate complexes and method of manufacture thereof |
| WO2005111052A1 (de) | 2004-05-17 | 2005-11-24 | Cilag Ag | Verfahren zur herstellung von eisen (iii) gluconatkomlex |
| ZA200702421B (en) | 2004-10-08 | 2008-09-25 | Unilever Plc | Iron complex for use in the treatment and/or prevention of nutritional disorders |
| GB0702270D0 (en) * | 2007-02-06 | 2007-03-14 | Medical Res Council | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| EA019635B1 (ru) * | 2007-02-06 | 2014-05-30 | Медикал Ресёрч Каунсил | Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения |
| GB0814326D0 (en) * | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
| CN101691485B (zh) * | 2009-07-29 | 2012-03-28 | 西南石油大学 | 钻井液用抗高温两性离子聚合物降滤失剂及其制备方法 |
| CN103272553B (zh) * | 2013-05-16 | 2015-05-13 | 武汉大学 | 一种用于除去水体中砷的磁性纳米氧化铁吸附剂的制备方法 |
| CN103626807B (zh) * | 2013-11-20 | 2017-07-07 | 青岛国风药业股份有限公司 | 一种多糖铁复合物的制备方法及其质量检测方法 |
| CN103848989B (zh) * | 2014-03-20 | 2016-06-08 | 南京大学 | 一种镍锌铁氧体/聚苯胺复合材料的制备方法 |
| WO2015178451A1 (ja) | 2014-05-23 | 2015-11-26 | 戸田工業株式会社 | ヘマタイト粒子粉末の製造方法、該ヘマタイト粒子粉末を用いた塗料及び樹脂組成物 |
-
2015
- 2015-10-09 GB GBGB1517893.2A patent/GB201517893D0/en not_active Ceased
-
2016
- 2016-10-07 CN CN201680058940.3A patent/CN108430964B/zh active Active
- 2016-10-07 HU HUE16778044A patent/HUE051502T2/hu unknown
- 2016-10-07 SG SG11201802770WA patent/SG11201802770WA/en unknown
- 2016-10-07 BR BR112018007098-0A patent/BR112018007098B1/pt active IP Right Grant
- 2016-10-07 JP JP2018517847A patent/JP7008624B2/ja active Active
- 2016-10-07 ES ES16778044T patent/ES2824452T3/es active Active
- 2016-10-07 EA EA201890601A patent/EA035547B1/ru unknown
- 2016-10-07 PL PL16778044T patent/PL3359519T3/pl unknown
- 2016-10-07 MX MX2018004113A patent/MX2018004113A/es unknown
- 2016-10-07 DK DK16778044.4T patent/DK3359519T3/da active
- 2016-10-07 SI SI201630967T patent/SI3359519T1/sl unknown
- 2016-10-07 AU AU2016333725A patent/AU2016333725B2/en active Active
- 2016-10-07 PT PT167780444T patent/PT3359519T/pt unknown
- 2016-10-07 US US15/765,367 patent/US10722459B2/en active Active
- 2016-10-07 CA CA3000589A patent/CA3000589C/en active Active
- 2016-10-07 WO PCT/EP2016/074022 patent/WO2017060441A1/en not_active Ceased
- 2016-10-07 EP EP16778044.4A patent/EP3359519B1/en active Active
-
2018
- 2018-04-04 ZA ZA2018/02192A patent/ZA201802192B/en unknown
-
2020
- 2020-01-21 US US16/747,821 patent/US11684572B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018007098B1 (pt) | 2023-10-10 |
| CA3000589C (en) | 2024-01-09 |
| PL3359519T3 (pl) | 2021-03-08 |
| EP3359519B1 (en) | 2020-08-12 |
| WO2017060441A1 (en) | 2017-04-13 |
| JP2018530565A (ja) | 2018-10-18 |
| HUE051502T2 (hu) | 2021-03-01 |
| AU2016333725B2 (en) | 2020-10-22 |
| ZA201802192B (en) | 2020-09-30 |
| CA3000589A1 (en) | 2017-04-13 |
| GB201517893D0 (en) | 2015-11-25 |
| MX2018004113A (es) | 2018-05-17 |
| PT3359519T (pt) | 2020-10-13 |
| CN108430964A (zh) | 2018-08-21 |
| HK1253078A1 (en) | 2019-06-06 |
| US20180271784A1 (en) | 2018-09-27 |
| SI3359519T1 (sl) | 2021-03-31 |
| CN108430964B (zh) | 2021-05-11 |
| JP7008624B2 (ja) | 2022-01-25 |
| US11684572B2 (en) | 2023-06-27 |
| US20200155453A1 (en) | 2020-05-21 |
| EA201890601A1 (ru) | 2018-11-30 |
| US10722459B2 (en) | 2020-07-28 |
| SG11201802770WA (en) | 2018-05-30 |
| EA035547B1 (ru) | 2020-07-06 |
| DK3359519T3 (da) | 2020-09-07 |
| AU2016333725A1 (en) | 2018-04-26 |
| BR112018007098A2 (pt) | 2019-01-15 |
| EP3359519A1 (en) | 2018-08-15 |
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