ES2813927T3 - Anticuerpos que neutralizan potencialmente el virus de la Hepatitis B y usos de los mismos - Google Patents

Anticuerpos que neutralizan potencialmente el virus de la Hepatitis B y usos de los mismos Download PDF

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Publication number
ES2813927T3
ES2813927T3 ES16779075T ES16779075T ES2813927T3 ES 2813927 T3 ES2813927 T3 ES 2813927T3 ES 16779075 T ES16779075 T ES 16779075T ES 16779075 T ES16779075 T ES 16779075T ES 2813927 T3 ES2813927 T3 ES 2813927T3
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Prior art keywords
antibody
antigen
binding fragment
hepatitis
seq
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ES16779075T
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English (en)
Spanish (es)
Inventor
Davide Corti
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Humabs Biomed SA
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Humabs Biomed SA
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES16779075T 2015-10-07 2016-10-07 Anticuerpos que neutralizan potencialmente el virus de la Hepatitis B y usos de los mismos Active ES2813927T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2015/001970 WO2017059878A1 (en) 2015-10-07 2015-10-07 Antibodies that potently neutralize hepatitis b virus and uses thereof
PCT/EP2016/074114 WO2017060504A1 (en) 2015-10-07 2016-10-07 Antibodies that potently neutralize hepatitis b virus and uses thereof

Publications (1)

Publication Number Publication Date
ES2813927T3 true ES2813927T3 (es) 2021-03-25

Family

ID=54330711

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16779075T Active ES2813927T3 (es) 2015-10-07 2016-10-07 Anticuerpos que neutralizan potencialmente el virus de la Hepatitis B y usos de los mismos

Country Status (24)

Country Link
US (3) US10683344B2 (enExample)
EP (2) EP3359564B1 (enExample)
JP (4) JP6869968B2 (enExample)
KR (1) KR102725168B1 (enExample)
CN (3) CN114539392B (enExample)
AU (1) AU2016334735B2 (enExample)
BR (1) BR112018002406A2 (enExample)
CA (1) CA2993745A1 (enExample)
CY (1) CY1123462T1 (enExample)
DK (1) DK3359564T3 (enExample)
EA (1) EA038301B1 (enExample)
ES (1) ES2813927T3 (enExample)
HR (1) HRP20201345T1 (enExample)
HU (1) HUE050231T2 (enExample)
IL (1) IL258326B (enExample)
LT (1) LT3359564T (enExample)
MX (1) MX2018004127A (enExample)
MY (1) MY187161A (enExample)
PH (1) PH12018500199A1 (enExample)
PL (1) PL3359564T3 (enExample)
PT (1) PT3359564T (enExample)
SI (1) SI3359564T1 (enExample)
WO (2) WO2017059878A1 (enExample)
ZA (1) ZA201800710B (enExample)

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SG11202105276TA (en) 2018-12-03 2021-06-29 Univ Texas Oligo-benzamide analogs and their use in cancer treatment
WO2020132091A2 (en) * 2018-12-19 2020-06-25 Humabs Biomed Sa Antibodies that neutralize hepatitis b virus and uses thereof
DK4285929T3 (da) * 2018-12-20 2025-12-22 Humabs Biomed Sa Kombinationsterapi mod hbv
KR102084912B1 (ko) * 2019-01-17 2020-03-05 주식회사 녹십자 B형 간염 바이러스 표면 항원의 입체 에피토프 및 이에 특이적으로 결합하는 항체
KR20220035483A (ko) 2019-07-20 2022-03-22 화후이 헬스 리미티드 항-pre-s1 hbv 항체를 이용한 hbv 감염 치료 방법
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TW202406932A (zh) 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
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CN113234144B (zh) * 2021-05-26 2022-02-25 武汉工程大学 一种人源性抗乙肝表面抗原的单链抗体、制剂、编码基因、载体质粒及宿主细胞
WO2023287352A2 (en) * 2021-07-15 2023-01-19 National University Of Singapore Anti-hbv antibodies and uses thereof
CN113777312B (zh) * 2021-09-03 2024-02-02 普十生物科技(北京)有限公司 乙肝抗体片段的制备方法、乙肝抗体片段、试剂盒及应用
US20240391979A1 (en) * 2021-09-13 2024-11-28 Achelois Biopharma, Inc. Hepatitis b virus antivirus (hbv-antivirus) compositions and methods of use
AU2022417396A1 (en) * 2021-12-21 2024-06-20 Hbvtech, Llc. Methods for eliminating hepatitis b virus cccdna and rcdna and the hepatitis b drugs used in the methods thereof
TW202411246A (zh) 2022-05-23 2024-03-16 美商維爾生物科技股份有限公司 經工程化之b型肝炎病毒中和抗體及其用途
CN116162153B (zh) * 2022-09-01 2024-09-10 复旦大学附属中山医院 一种乙肝病毒表面抗原的单克隆抗体及其应用
CN118725092B (zh) * 2023-03-28 2025-08-12 东莞市朋志生物科技有限公司 抗HBs-Ag抗体、检测HBs-Ag的试剂和试剂盒
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CN119143869A (zh) * 2023-06-16 2024-12-17 复旦大学 乙肝病毒表面抗体及其应用

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Also Published As

Publication number Publication date
JP7171809B2 (ja) 2022-11-15
IL258326B (en) 2021-10-31
US20230303663A1 (en) 2023-09-28
WO2017060504A1 (en) 2017-04-13
JP2021121188A (ja) 2021-08-26
CN114539391A (zh) 2022-05-27
US20190016785A1 (en) 2019-01-17
BR112018002406A2 (pt) 2018-09-18
MY187161A (en) 2021-09-06
EP3359564B1 (en) 2020-06-03
AU2016334735B2 (en) 2022-10-27
KR102725168B1 (ko) 2024-10-31
CN108137675A (zh) 2018-06-08
US20210040183A1 (en) 2021-02-11
HRP20201345T1 (hr) 2020-11-27
CN114539392B (zh) 2024-01-26
JP2024097078A (ja) 2024-07-17
CN114539392A (zh) 2022-05-27
PL3359564T3 (pl) 2020-11-30
EP3359564A1 (en) 2018-08-15
ZA201800710B (en) 2019-05-29
IL258326A (en) 2018-05-31
CY1123462T1 (el) 2022-03-24
CA2993745A1 (en) 2017-04-13
EA201890874A1 (ru) 2018-11-30
US12037381B2 (en) 2024-07-16
PH12018500199A1 (en) 2018-08-13
DK3359564T3 (da) 2020-08-17
JP6869968B2 (ja) 2021-05-12
LT3359564T (lt) 2020-10-26
WO2017059878A1 (en) 2017-04-13
EA038301B1 (ru) 2021-08-06
EP3753949A1 (en) 2020-12-23
HK1256869A1 (en) 2019-10-04
JP2023011809A (ja) 2023-01-24
HUE050231T2 (hu) 2020-11-30
US10683344B2 (en) 2020-06-16
JP2018535650A (ja) 2018-12-06
US11390664B2 (en) 2022-07-19
NZ739360A (en) 2024-10-25
SI3359564T1 (sl) 2020-10-30
KR20180056777A (ko) 2018-05-29
AU2016334735A1 (en) 2018-02-15
MX2018004127A (es) 2018-06-13
CN108137675B (zh) 2022-03-22
PT3359564T (pt) 2020-09-04

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