KR102725168B1 - B형 간염 바이러스를 강력하게 중화하는 항체 및 그의 용도 - Google Patents

B형 간염 바이러스를 강력하게 중화하는 항체 및 그의 용도 Download PDF

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KR102725168B1
KR102725168B1 KR1020187012979A KR20187012979A KR102725168B1 KR 102725168 B1 KR102725168 B1 KR 102725168B1 KR 1020187012979 A KR1020187012979 A KR 1020187012979A KR 20187012979 A KR20187012979 A KR 20187012979A KR 102725168 B1 KR102725168 B1 KR 102725168B1
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antibody
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antigen
hepatitis
binding fragment
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KR20180056777A (ko
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다비드 코르티
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후맙스 바이오메드 에스에이
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020187012979A 2015-10-07 2016-10-07 B형 간염 바이러스를 강력하게 중화하는 항체 및 그의 용도 Active KR102725168B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2015/001970 WO2017059878A1 (en) 2015-10-07 2015-10-07 Antibodies that potently neutralize hepatitis b virus and uses thereof
EPPCT/EP2015/001970 2015-10-07
PCT/EP2016/074114 WO2017060504A1 (en) 2015-10-07 2016-10-07 Antibodies that potently neutralize hepatitis b virus and uses thereof

Publications (2)

Publication Number Publication Date
KR20180056777A KR20180056777A (ko) 2018-05-29
KR102725168B1 true KR102725168B1 (ko) 2024-10-31

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US (3) US10683344B2 (enExample)
EP (2) EP3359564B1 (enExample)
JP (4) JP6869968B2 (enExample)
KR (1) KR102725168B1 (enExample)
CN (3) CN108137675B (enExample)
AU (1) AU2016334735B2 (enExample)
BR (1) BR112018002406A2 (enExample)
CA (1) CA2993745A1 (enExample)
CY (1) CY1123462T1 (enExample)
DK (1) DK3359564T3 (enExample)
EA (1) EA038301B1 (enExample)
ES (1) ES2813927T3 (enExample)
HR (1) HRP20201345T1 (enExample)
HU (1) HUE050231T2 (enExample)
IL (1) IL258326B (enExample)
LT (1) LT3359564T (enExample)
MX (1) MX2018004127A (enExample)
MY (1) MY187161A (enExample)
PH (1) PH12018500199A1 (enExample)
PL (1) PL3359564T3 (enExample)
PT (1) PT3359564T (enExample)
SI (1) SI3359564T1 (enExample)
WO (2) WO2017059878A1 (enExample)
ZA (1) ZA201800710B (enExample)

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WO2017059878A1 (en) * 2015-10-07 2017-04-13 Humabs Biomed Sa Antibodies that potently neutralize hepatitis b virus and uses thereof
CN112513063A (zh) * 2018-05-10 2021-03-16 克莱尔博治疗有限公司 用于治疗乙型肝炎感染的方法和组合物
EP3793603A4 (en) * 2018-05-16 2022-01-26 Chang Gung Memorial Hospital, Linkou Novel leucine-rich repeat neuronal protein 1 (lrrn1) antibodies and uses thereof
US11932681B2 (en) 2018-05-31 2024-03-19 Novartis Ag Hepatitis B antibodies
JP7558167B2 (ja) 2018-12-03 2024-09-30 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム オリゴベンズアミド類似体およびがん処置におけるそれらの使用
HRP20231440T1 (hr) * 2018-12-19 2024-03-01 Humabs Biomed Sa Protutijela koja neutraliziraju virus hepatitisa b i njihova upotreba
EA202191736A1 (ru) * 2018-12-20 2021-10-01 Вир Байотекнолоджи, Инк. Комбинированная терапия hbv
KR102084912B1 (ko) * 2019-01-17 2020-03-05 주식회사 녹십자 B형 간염 바이러스 표면 항원의 입체 에피토프 및 이에 특이적으로 결합하는 항체
US20220259292A1 (en) * 2019-07-20 2022-08-18 Huahui Health Ltd. A method of treating hbv infection by using anti-pre-s1 hbv antibodies
MX2022002231A (es) 2019-08-29 2022-03-22 Vir Biotechnology Inc Composiciones de anticuerpos y metodos para tratar la infeccion por el virus de la hepatitis b.
CN113717283B (zh) * 2020-05-25 2023-05-26 厦门万泰凯瑞生物技术有限公司 一种抗乙型肝炎病毒e抗原的单克隆抗体及其应用
BR112022024996A2 (pt) * 2020-06-08 2022-12-27 Hoffmann La Roche Anticorpos, ácido nucleico, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, agente terapêutico, uso do anticorpo e método para tratar um indivíduo com hepatite b
TW202207950A (zh) * 2020-06-22 2022-03-01 美商詹森藥物公司 治療d型肝炎病毒感染之組合物及方法
BR112022026316A2 (pt) * 2020-06-24 2023-03-07 Vir Biotechnology Inc Anticorpos neutralizantes do vírus da hepatite b engenheirados e usos dos mesmos
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
TW202245838A (zh) 2021-01-26 2022-12-01 美商維爾生物科技股份有限公司 用於治療b型肝炎病毒感染的組成物及方法
CN113234144B (zh) * 2021-05-26 2022-02-25 武汉工程大学 一种人源性抗乙肝表面抗原的单链抗体、制剂、编码基因、载体质粒及宿主细胞
US20240327500A1 (en) * 2021-07-15 2024-10-03 National University Of Singapore Anti-hbv antibodies and uses thereof
CN113777312B (zh) * 2021-09-03 2024-02-02 普十生物科技(北京)有限公司 乙肝抗体片段的制备方法、乙肝抗体片段、试剂盒及应用
WO2023039243A2 (en) * 2021-09-13 2023-03-16 Achelois Biopharma, Inc. Hepatitis b virus antivirus (hbv-antivirus) compositions and methods of use
WO2023122555A2 (en) * 2021-12-21 2023-06-29 Hbvtech, Llc. Methods for eliminating hepatitis b virus cccdna and rcdna and the hepatitis b drugs used in the methods thereof
AR129399A1 (es) 2022-05-23 2024-08-21 Vir Biotechnology Inc Anticuerpos diseñados neutralizantes del virus de la hepatitis b y usos de los mismos
CN116162153B (zh) * 2022-09-01 2024-09-10 复旦大学附属中山医院 一种乙肝病毒表面抗原的单克隆抗体及其应用
CN118725092B (zh) * 2023-03-28 2025-08-12 东莞市朋志生物科技有限公司 抗HBs-Ag抗体、检测HBs-Ag的试剂和试剂盒
US20240400650A1 (en) * 2023-05-31 2024-12-05 Bluejay Therapeutics, Inc. Anti-HBsAg antibody for treatment of chronic hepatitis D
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Also Published As

Publication number Publication date
KR20180056777A (ko) 2018-05-29
EP3359564A1 (en) 2018-08-15
EP3359564B1 (en) 2020-06-03
LT3359564T (lt) 2020-10-26
JP2023011809A (ja) 2023-01-24
BR112018002406A2 (pt) 2018-09-18
CN114539392B (zh) 2024-01-26
HRP20201345T1 (hr) 2020-11-27
US10683344B2 (en) 2020-06-16
EP3753949A1 (en) 2020-12-23
AU2016334735A1 (en) 2018-02-15
CN108137675B (zh) 2022-03-22
US11390664B2 (en) 2022-07-19
US12037381B2 (en) 2024-07-16
MY187161A (en) 2021-09-06
US20230303663A1 (en) 2023-09-28
JP6869968B2 (ja) 2021-05-12
PH12018500199A1 (en) 2018-08-13
EA201890874A1 (ru) 2018-11-30
ES2813927T3 (es) 2021-03-25
EA038301B1 (ru) 2021-08-06
WO2017060504A1 (en) 2017-04-13
US20210040183A1 (en) 2021-02-11
WO2017059878A1 (en) 2017-04-13
CY1123462T1 (el) 2022-03-24
IL258326B (en) 2021-10-31
PT3359564T (pt) 2020-09-04
IL258326A (en) 2018-05-31
CN108137675A (zh) 2018-06-08
SI3359564T1 (sl) 2020-10-30
JP2024097078A (ja) 2024-07-17
CN114539391A (zh) 2022-05-27
AU2016334735B2 (en) 2022-10-27
NZ739360A (en) 2024-10-25
HUE050231T2 (hu) 2020-11-30
CA2993745A1 (en) 2017-04-13
PL3359564T3 (pl) 2020-11-30
JP2018535650A (ja) 2018-12-06
CN114539392A (zh) 2022-05-27
JP7171809B2 (ja) 2022-11-15
MX2018004127A (es) 2018-06-13
US20190016785A1 (en) 2019-01-17
DK3359564T3 (da) 2020-08-17
HK1256869A1 (en) 2019-10-04
JP2021121188A (ja) 2021-08-26
ZA201800710B (en) 2019-05-29

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