JP6869968B2 - Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用 - Google Patents

Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用 Download PDF

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JP6869968B2
JP6869968B2 JP2018514962A JP2018514962A JP6869968B2 JP 6869968 B2 JP6869968 B2 JP 6869968B2 JP 2018514962 A JP2018514962 A JP 2018514962A JP 2018514962 A JP2018514962 A JP 2018514962A JP 6869968 B2 JP6869968 B2 JP 6869968B2
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antibody
antigen
seq
binding fragment
nucleic acid
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JP2018535650A5 (enExample
JP2018535650A (ja
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ダヴィデ・コルティ
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Humabs Biomed SA
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Humabs Biomed SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2018514962A 2015-10-07 2016-10-07 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用 Active JP6869968B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021068062A JP7171809B2 (ja) 2015-10-07 2021-04-14 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用
JP2022175909A JP2023011809A (ja) 2015-10-07 2022-11-02 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用
JP2024074160A JP2024097078A (ja) 2015-10-07 2024-05-01 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用

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Application Number Priority Date Filing Date Title
PCT/EP2015/001970 WO2017059878A1 (en) 2015-10-07 2015-10-07 Antibodies that potently neutralize hepatitis b virus and uses thereof
EPPCT/EP2015/001970 2015-10-07
PCT/EP2016/074114 WO2017060504A1 (en) 2015-10-07 2016-10-07 Antibodies that potently neutralize hepatitis b virus and uses thereof

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JP2018535650A JP2018535650A (ja) 2018-12-06
JP2018535650A5 JP2018535650A5 (enExample) 2019-10-31
JP6869968B2 true JP6869968B2 (ja) 2021-05-12

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JP2018514962A Active JP6869968B2 (ja) 2015-10-07 2016-10-07 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用
JP2021068062A Active JP7171809B2 (ja) 2015-10-07 2021-04-14 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用
JP2022175909A Withdrawn JP2023011809A (ja) 2015-10-07 2022-11-02 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用
JP2024074160A Pending JP2024097078A (ja) 2015-10-07 2024-05-01 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用

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JP2022175909A Withdrawn JP2023011809A (ja) 2015-10-07 2022-11-02 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用
JP2024074160A Pending JP2024097078A (ja) 2015-10-07 2024-05-01 Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用

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CN (3) CN108137675B (enExample)
AU (1) AU2016334735B2 (enExample)
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CA (1) CA2993745A1 (enExample)
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HR (1) HRP20201345T1 (enExample)
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Cited By (1)

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JP2023011809A (ja) * 2015-10-07 2023-01-24 ヒューマブス バイオメド エスエー Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用

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JP2024504167A (ja) 2021-01-26 2024-01-30 ヴィア・バイオテクノロジー・インコーポレイテッド Ｂ型肝炎ウイルス感染を処置するための抗体組成物および方法
CN113234144B (zh) * 2021-05-26 2022-02-25 武汉工程大学 一种人源性抗乙肝表面抗原的单链抗体、制剂、编码基因、载体质粒及宿主细胞
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Publication number Priority date Publication date Assignee Title
JP2023011809A (ja) * 2015-10-07 2023-01-24 ヒューマブス バイオメド エスエー Ｂ型肝炎ウイルスを強力に中和する抗体及びその使用
US12037381B2 (en) 2015-10-07 2024-07-16 Humabs Biomed Sa Antibodies that potently neutralize hepatitis B virus and uses thereof

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EP3359564B1 (en) 2020-06-03
CN108137675A (zh) 2018-06-08
DK3359564T3 (da) 2020-08-17
JP2023011809A (ja) 2023-01-24
US11390664B2 (en) 2022-07-19
EA201890874A1 (ru) 2018-11-30
CN108137675B (zh) 2022-03-22
EP3359564A1 (en) 2018-08-15
ZA201800710B (en) 2019-05-29
PL3359564T3 (pl) 2020-11-30
US20190016785A1 (en) 2019-01-17
KR20180056777A (ko) 2018-05-29
WO2017060504A1 (en) 2017-04-13
AU2016334735B2 (en) 2022-10-27
JP2018535650A (ja) 2018-12-06
AU2016334735A1 (en) 2018-02-15
KR102725168B1 (ko) 2024-10-31
HRP20201345T1 (hr) 2020-11-27
JP2021121188A (ja) 2021-08-26
MX2018004127A (es) 2018-06-13
IL258326A (en) 2018-05-31
LT3359564T (lt) 2020-10-26
CA2993745A1 (en) 2017-04-13
IL258326B (en) 2021-10-31
CN114539392A (zh) 2022-05-27
HUE050231T2 (hu) 2020-11-30
JP7171809B2 (ja) 2022-11-15
US10683344B2 (en) 2020-06-16
PT3359564T (pt) 2020-09-04
CY1123462T1 (el) 2022-03-24
US20210040183A1 (en) 2021-02-11
SI3359564T1 (sl) 2020-10-30
HK1256869A1 (en) 2019-10-04
ES2813927T3 (es) 2021-03-25
EP3753949A1 (en) 2020-12-23
NZ739360A (en) 2024-10-25
CN114539391A (zh) 2022-05-27
PH12018500199A1 (en) 2018-08-13
CN114539392B (zh) 2024-01-26
EA038301B1 (ru) 2021-08-06
WO2017059878A1 (en) 2017-04-13
US12037381B2 (en) 2024-07-16
JP2024097078A (ja) 2024-07-17
US20230303663A1 (en) 2023-09-28
MY187161A (en) 2021-09-06
BR112018002406A2 (pt) 2018-09-18

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