ES2811098T3 - Citrato de (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidin-1-il)(5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2hpirano-2-il) metilamino)pirimidin-4il) metanona - Google Patents
Citrato de (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidin-1-il)(5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2hpirano-2-il) metilamino)pirimidin-4il) metanona Download PDFInfo
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- ES2811098T3 ES2811098T3 ES16818898T ES16818898T ES2811098T3 ES 2811098 T3 ES2811098 T3 ES 2811098T3 ES 16818898 T ES16818898 T ES 16818898T ES 16818898 T ES16818898 T ES 16818898T ES 2811098 T3 ES2811098 T3 ES 2811098T3
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15175066 | 2015-07-02 | ||
| PCT/US2016/040728 WO2017004537A1 (en) | 2015-07-02 | 2016-07-01 | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
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| ES2811098T3 true ES2811098T3 (es) | 2021-03-10 |
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| ES16818898T Active ES2811098T3 (es) | 2015-07-02 | 2016-07-01 | Citrato de (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidin-1-il)(5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2hpirano-2-il) metilamino)pirimidin-4il) metanona |
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| PH12012501215A1 (en) | 2009-12-17 | 2015-11-13 | Centrexion Therapeutics Corp | New ccr2 receptor antagonists and uses thereof |
| MX383744B (es) * | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
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| US20250333398A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228902A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Heterocyclic acids as sting antagonists and the use thereof as medicament |
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| JP5658272B2 (ja) | 2009-12-17 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 |
| PH12012501215A1 (en) * | 2009-12-17 | 2015-11-13 | Centrexion Therapeutics Corp | New ccr2 receptor antagonists and uses thereof |
| JP5746228B2 (ja) | 2010-03-05 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を選択的に調節するテトラゾール化合物 |
| US8877745B2 (en) | 2010-05-12 | 2014-11-04 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2569295B1 (en) | 2010-05-12 | 2014-11-19 | Boehringer Ingelheim International GmbH | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| JP5636094B2 (ja) | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体アンタゴニスト |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| WO2012171863A1 (en) | 2011-06-16 | 2012-12-20 | Boehringer Ingelheim International Gmbh | New selective ccr2 antagonists |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| JP6229575B2 (ja) | 2014-03-31 | 2017-11-15 | 京セラドキュメントソリューションズ株式会社 | 画像処理装置 |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
-
2016
- 2016-07-01 MX MX2017017177A patent/MX383744B/es unknown
- 2016-07-01 JP JP2017568018A patent/JP6917910B2/ja active Active
- 2016-07-01 CA CA2990460A patent/CA2990460C/en active Active
- 2016-07-01 BR BR112017028492-8A patent/BR112017028492B1/pt active IP Right Grant
- 2016-07-01 PL PL16818898T patent/PL3317270T3/pl unknown
- 2016-07-01 ES ES16818898T patent/ES2811098T3/es active Active
- 2016-07-01 EP EP16818898.5A patent/EP3317270B1/en active Active
- 2016-07-01 PT PT168188985T patent/PT3317270T/pt unknown
- 2016-07-01 WO PCT/US2016/040728 patent/WO2017004537A1/en not_active Ceased
- 2016-07-01 CN CN201680045214.8A patent/CN108026087B/zh active Active
- 2016-07-01 AU AU2016287584A patent/AU2016287584B2/en active Active
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2017
- 2017-12-21 US US15/849,929 patent/US10213428B2/en active Active
- 2017-12-24 IL IL256530A patent/IL256530A/en active IP Right Grant
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2018
- 2018-12-19 US US16/224,902 patent/US10568885B2/en active Active
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2020
- 2020-02-11 US US16/787,433 patent/US11147814B2/en not_active Expired - Fee Related
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2021
- 2021-10-13 US US17/500,367 patent/US12076321B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016287584A1 (en) | 2018-04-19 |
| PT3317270T (pt) | 2020-08-24 |
| US20200276197A1 (en) | 2020-09-03 |
| US10213428B2 (en) | 2019-02-26 |
| JP6917910B2 (ja) | 2021-08-11 |
| NZ738565A (en) | 2024-10-25 |
| CN108026087A (zh) | 2018-05-11 |
| US20180207157A1 (en) | 2018-07-26 |
| MX383744B (es) | 2025-03-14 |
| WO2017004537A1 (en) | 2017-01-05 |
| IL256530A (en) | 2018-02-28 |
| CA2990460A1 (en) | 2017-01-05 |
| US11147814B2 (en) | 2021-10-19 |
| BR112017028492B1 (pt) | 2023-12-26 |
| JP2018524342A (ja) | 2018-08-30 |
| US20220133723A1 (en) | 2022-05-05 |
| AU2016287584B2 (en) | 2020-03-26 |
| MX2017017177A (es) | 2018-11-09 |
| CN108026087B (zh) | 2021-06-04 |
| BR112017028492A2 (pt) | 2018-08-28 |
| PL3317270T3 (pl) | 2020-11-16 |
| EP3317270A4 (en) | 2019-01-02 |
| EP3317270A1 (en) | 2018-05-09 |
| CA2990460C (en) | 2023-10-17 |
| US20190262339A1 (en) | 2019-08-29 |
| HK1254741A1 (en) | 2019-07-26 |
| US12076321B2 (en) | 2024-09-03 |
| US10568885B2 (en) | 2020-02-25 |
| EP3317270B1 (en) | 2020-05-13 |
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