AU2016287584B2 - (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate - Google Patents
(4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate Download PDFInfo
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- AU2016287584B2 AU2016287584B2 AU2016287584A AU2016287584A AU2016287584B2 AU 2016287584 B2 AU2016287584 B2 AU 2016287584B2 AU 2016287584 A AU2016287584 A AU 2016287584A AU 2016287584 A AU2016287584 A AU 2016287584A AU 2016287584 B2 AU2016287584 B2 AU 2016287584B2
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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| Application Number | Priority Date | Filing Date | Title |
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| EP15175066.8 | 2015-07-02 | ||
| EP15175066 | 2015-07-02 | ||
| PCT/US2016/040728 WO2017004537A1 (en) | 2015-07-02 | 2016-07-01 | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
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| AU2016287584A1 AU2016287584A1 (en) | 2018-04-19 |
| AU2016287584B2 true AU2016287584B2 (en) | 2020-03-26 |
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| AU2016287584A Active AU2016287584B2 (en) | 2015-07-02 | 2016-07-01 | (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
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| PH12012501215A1 (en) | 2009-12-17 | 2015-11-13 | Centrexion Therapeutics Corp | New ccr2 receptor antagonists and uses thereof |
| MX383744B (es) * | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
| WO2025228899A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Further heterocyclic compounds as sting antagonists and the use thereof as medicament |
| WO2025228895A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| US20250333398A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228902A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Heterocyclic acids as sting antagonists and the use thereof as medicament |
| WO2025228900A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Arylamide substituted indazoles and the use thereof as medicament |
| WO2025228889A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Monoarylic heterocyclic compounds as sting antagonists and the use thereof as medicament |
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| WO2011073154A1 (en) * | 2009-12-17 | 2011-06-23 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists and uses thereof |
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| JP5658272B2 (ja) | 2009-12-17 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 |
| JP5746228B2 (ja) | 2010-03-05 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を選択的に調節するテトラゾール化合物 |
| US8877745B2 (en) | 2010-05-12 | 2014-11-04 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2569295B1 (en) | 2010-05-12 | 2014-11-19 | Boehringer Ingelheim International GmbH | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| JP5636094B2 (ja) | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体アンタゴニスト |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| WO2012171863A1 (en) | 2011-06-16 | 2012-12-20 | Boehringer Ingelheim International Gmbh | New selective ccr2 antagonists |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| JP6229575B2 (ja) | 2014-03-31 | 2017-11-15 | 京セラドキュメントソリューションズ株式会社 | 画像処理装置 |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
-
2016
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- 2016-07-01 JP JP2017568018A patent/JP6917910B2/ja active Active
- 2016-07-01 CA CA2990460A patent/CA2990460C/en active Active
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- 2016-07-01 PL PL16818898T patent/PL3317270T3/pl unknown
- 2016-07-01 ES ES16818898T patent/ES2811098T3/es active Active
- 2016-07-01 EP EP16818898.5A patent/EP3317270B1/en active Active
- 2016-07-01 PT PT168188985T patent/PT3317270T/pt unknown
- 2016-07-01 WO PCT/US2016/040728 patent/WO2017004537A1/en not_active Ceased
- 2016-07-01 CN CN201680045214.8A patent/CN108026087B/zh active Active
- 2016-07-01 AU AU2016287584A patent/AU2016287584B2/en active Active
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2017
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2018
- 2018-12-19 US US16/224,902 patent/US10568885B2/en active Active
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2020
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2021
- 2021-10-13 US US17/500,367 patent/US12076321B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011073154A1 (en) * | 2009-12-17 | 2011-06-23 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists and uses thereof |
| US9670222B2 (en) * | 2009-12-17 | 2017-06-06 | Centrexion Therapeutics Corporation | CCR2 receptor antagonists and uses thereof |
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|---|---|
| AU2016287584A1 (en) | 2018-04-19 |
| PT3317270T (pt) | 2020-08-24 |
| US20200276197A1 (en) | 2020-09-03 |
| US10213428B2 (en) | 2019-02-26 |
| JP6917910B2 (ja) | 2021-08-11 |
| NZ738565A (en) | 2024-10-25 |
| CN108026087A (zh) | 2018-05-11 |
| US20180207157A1 (en) | 2018-07-26 |
| MX383744B (es) | 2025-03-14 |
| WO2017004537A1 (en) | 2017-01-05 |
| IL256530A (en) | 2018-02-28 |
| CA2990460A1 (en) | 2017-01-05 |
| US11147814B2 (en) | 2021-10-19 |
| BR112017028492B1 (pt) | 2023-12-26 |
| JP2018524342A (ja) | 2018-08-30 |
| US20220133723A1 (en) | 2022-05-05 |
| MX2017017177A (es) | 2018-11-09 |
| CN108026087B (zh) | 2021-06-04 |
| BR112017028492A2 (pt) | 2018-08-28 |
| ES2811098T3 (es) | 2021-03-10 |
| PL3317270T3 (pl) | 2020-11-16 |
| EP3317270A4 (en) | 2019-01-02 |
| EP3317270A1 (en) | 2018-05-09 |
| CA2990460C (en) | 2023-10-17 |
| US20190262339A1 (en) | 2019-08-29 |
| HK1254741A1 (en) | 2019-07-26 |
| US12076321B2 (en) | 2024-09-03 |
| US10568885B2 (en) | 2020-02-25 |
| EP3317270B1 (en) | 2020-05-13 |
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