ES2772131T3 - Un nuevo proceso para la preparación de Febuxostat - Google Patents

Un nuevo proceso para la preparación de Febuxostat Download PDF

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Publication number
ES2772131T3
ES2772131T3 ES14750307T ES14750307T ES2772131T3 ES 2772131 T3 ES2772131 T3 ES 2772131T3 ES 14750307 T ES14750307 T ES 14750307T ES 14750307 T ES14750307 T ES 14750307T ES 2772131 T3 ES2772131 T3 ES 2772131T3
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ES
Spain
Prior art keywords
group
compound
formula
copper
febuxostat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14750307T
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English (en)
Spanish (es)
Inventor
Theocharis Koftis
Efstratios Neokosmidis
Sakellarios Trakossas
Theodoros Panagiotidis
Thanos Andreou
Anastasia-Aikaterini Varvogli
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Pharmathen SA
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Pharmathen SA
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Publication of ES2772131T3 publication Critical patent/ES2772131T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES14750307T 2013-08-07 2014-07-30 Un nuevo proceso para la preparación de Febuxostat Active ES2772131T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2013002361 2013-08-07
PCT/EP2014/002079 WO2015018507A2 (en) 2013-08-07 2014-07-30 A novel process for the preparation of febuxostat

Publications (1)

Publication Number Publication Date
ES2772131T3 true ES2772131T3 (es) 2020-07-07

Family

ID=51302690

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14750307T Active ES2772131T3 (es) 2013-08-07 2014-07-30 Un nuevo proceso para la preparación de Febuxostat

Country Status (4)

Country Link
JP (2) JP6585044B2 (show.php)
CN (1) CN105452228B (show.php)
ES (1) ES2772131T3 (show.php)
WO (1) WO2015018507A2 (show.php)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108440443A (zh) * 2018-05-16 2018-08-24 无棣锐新医药化工有限公司 非布索坦中间体的制备方法
CN109503512B (zh) * 2018-12-28 2021-05-07 大连理工大学 一种非布司他及其中间体的合成方法
CN109503513B (zh) * 2018-12-29 2020-09-25 嘉实（湖南）医药科技有限公司 一种非布司他中间体的“一锅法”合成方法
CN113072519A (zh) * 2021-04-01 2021-07-06 福建海西新药创制有限公司 一种利用微反应装置连续生产非布司他的方法
CN117924211A (zh) * 2023-12-06 2024-04-26 哈药集团技术中心 一种非布司他的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009279A1 (fr) 1990-11-30 1992-06-11 Teijin Limited Derive de 2-arylthiazole et composition pharmaceutique contenant ce derive
JP2706037B2 (ja) 1993-04-13 1998-01-28 帝人株式会社 シアノ化合物およびその製造方法
JP2834971B2 (ja) * 1993-05-25 1998-12-14 帝人株式会社 ２−（４−アルコキシ−３−シアノフェニル）チアゾール誘導体の製造法およびその新規製造中間体
JP3202607B2 (ja) * 1996-08-01 2001-08-27 帝人株式会社 ２−（４−アルコキシ−３−シアノフェニル）チアゾール誘導体の製造法
EP2332940B1 (en) * 2004-03-30 2012-10-31 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of JAK and other protein kinases
CN101412700B (zh) * 2007-10-19 2011-06-08 上海医药工业研究院 非布司他的晶型及其制备方法
EP2266966A1 (en) 2009-06-11 2010-12-29 Chemo Ibérica, S.A. A process for the preparation of febuxostat
CN102079731A (zh) * 2009-11-26 2011-06-01 上海和臣医药工程有限公司 一种2-(3-氰基-4-(2-甲基丙氧基)苯基)-4-甲基-5-噻唑甲酸的合成方法
CN101723915B (zh) * 2009-12-25 2012-01-25 北京赛科药业有限责任公司 一种制备非布索坦中间体的方法
WO2011141933A2 (en) * 2010-05-12 2011-11-17 Msn Laboratories Limited Process for preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid and its pharmaceutically acceptable salts
WO2012066561A1 (en) * 2010-11-08 2012-05-24 Matrix Laboratories Ltd An improved process for the preparation of 2-arylthiazole derivatives

Also Published As

Publication number Publication date
WO2015018507A3 (en) 2015-10-22
CN105452228A (zh) 2016-03-30
JP6585044B2 (ja) 2019-10-02
CN105452228B (zh) 2018-10-09
WO2015018507A2 (en) 2015-02-12
JP2019194203A (ja) 2019-11-07
JP2017509581A (ja) 2017-04-06

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