ES2741507T3 - Compuestos de glp-1 acilados doblemente - Google Patents
Compuestos de glp-1 acilados doblemente Download PDFInfo
- Publication number
- ES2741507T3 ES2741507T3 ES15713772T ES15713772T ES2741507T3 ES 2741507 T3 ES2741507 T3 ES 2741507T3 ES 15713772 T ES15713772 T ES 15713772T ES 15713772 T ES15713772 T ES 15713772T ES 2741507 T3 ES2741507 T3 ES 2741507T3
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- Prior art keywords
- ethoxy
- amino
- acetyl
- glp
- carboxy
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
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Landscapes
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| TWI797133B (zh) | 2017-06-09 | 2023-04-01 | 丹麥商諾佛 儂迪克股份有限公司 | 用於經口投予的固體組成物 |
| CN111050750B (zh) | 2017-08-24 | 2024-09-24 | 诺和诺德股份有限公司 | Glp-1组合物及其用途 |
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| WO2019200594A1 (zh) * | 2018-04-19 | 2019-10-24 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| WO2020077129A1 (en) | 2018-10-11 | 2020-04-16 | Intarcia Therapeutics, Inc. | Human amylin analog polypeptides and methods of use |
| CN111378027B (zh) * | 2018-12-29 | 2022-04-15 | 万新医药科技(苏州)有限公司 | 一种索玛鲁肽前体的制备方法 |
| JP7767264B2 (ja) * | 2019-09-02 | 2025-11-11 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１ペプチドを含む錠剤を生成するためのプロセス |
| JP7670698B2 (ja) | 2019-11-06 | 2025-04-30 | ノヴォ ノルディスク アー／エス | 認知症におけるｇｌｐ－１受容体作動薬 |
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| US7291594B2 (en) | 2002-10-11 | 2007-11-06 | Sanwa Kagaku Kenkyusho Co., Ltd. | GLP-1 derivative and preparation thereof absorbable via mucous membrane |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| CN101842109B (zh) | 2007-09-05 | 2014-01-29 | 诺沃-诺迪斯克有限公司 | 用a-b-c-d-衍生的肽和它们的治疗用途 |
| CN111560060A (zh) * | 2009-12-16 | 2020-08-21 | 诺沃—诺迪斯克有限公司 | 双酰化glp-1衍生物 |
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| AU2014210751A1 (en) * | 2013-01-29 | 2015-08-06 | Oshadi Drug Administration Ltd. | Pharmaceutical compositions for oral treatment of diabetes |
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| WO2015155151A1 (en) | 2015-10-15 |
| EP3129041B1 (en) | 2019-06-12 |
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| EP3129041A1 (en) | 2017-02-15 |
| CN106132985A (zh) | 2016-11-16 |
| CN106132985B (zh) | 2020-10-13 |
| US10689429B2 (en) | 2020-06-23 |
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