JP6768515B2 - 二重アシル化ｇｌｐ−１化合物 - Google Patents
二重アシル化ｇｌｐ−１化合物 Download PDFInfo
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- JP6768515B2 JP6768515B2 JP2016561311A JP2016561311A JP6768515B2 JP 6768515 B2 JP6768515 B2 JP 6768515B2 JP 2016561311 A JP2016561311 A JP 2016561311A JP 2016561311 A JP2016561311 A JP 2016561311A JP 6768515 B2 JP6768515 B2 JP 6768515B2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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| EP14163697.7 | 2014-04-07 | ||
| EP14163697 | 2014-04-07 | ||
| PCT/EP2015/057442 WO2015155151A1 (en) | 2014-04-07 | 2015-04-07 | Double-acylated glp-1 compounds |
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| JP2017514801A JP2017514801A (ja) | 2017-06-08 |
| JP2017514801A5 JP2017514801A5 (enExample) | 2018-05-10 |
| JP6768515B2 true JP6768515B2 (ja) | 2020-10-14 |
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| JP2016561311A Active JP6768515B2 (ja) | 2014-04-07 | 2015-04-07 | 二重アシル化ｇｌｐ−１化合物 |
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| EP (1) | EP3129041B1 (enExample) |
| JP (1) | JP6768515B2 (enExample) |
| CN (1) | CN106132985B (enExample) |
| ES (1) | ES2741507T3 (enExample) |
| WO (1) | WO2015155151A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| WO2017149070A1 (en) | 2016-03-03 | 2017-09-08 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
| TWI797133B (zh) | 2017-06-09 | 2023-04-01 | 丹麥商諾佛 儂迪克股份有限公司 | 用於經口投予的固體組成物 |
| RS65380B1 (sr) | 2017-08-24 | 2024-04-30 | Novo Nordisk As | Glp-1 kompozicije i njihova upotreba |
| AR114353A1 (es) * | 2018-02-02 | 2020-08-26 | Novo Nordisk As | Composiciones sólidas que comprenden un agonista del glp-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico |
| WO2019200594A1 (zh) * | 2018-04-19 | 2019-10-24 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| IL320142A (en) | 2018-10-11 | 2025-06-01 | Intarcia Therapeutics Inc | Human amylin analog polypeptides and methods of use |
| CN111378027B (zh) * | 2018-12-29 | 2022-04-15 | 万新医药科技(苏州)有限公司 | 一种索玛鲁肽前体的制备方法 |
| EP4025192B1 (en) * | 2019-09-02 | 2025-12-03 | Novo Nordisk A/S | Process for producing a tablet comprising glp-1 peptides |
| JP7670698B2 (ja) | 2019-11-06 | 2025-04-30 | ノヴォ ノルディスク アー／エス | 認知症におけるｇｌｐ－１受容体作動薬 |
| CN114641276A (zh) | 2019-11-07 | 2022-06-17 | 诺和诺德股份有限公司 | 包含glp-1激动剂、sglt2抑制剂和n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐的固体组合物 |
| CN115135304A (zh) | 2020-02-18 | 2022-09-30 | 诺和诺德股份有限公司 | Glp-1组合物及其用途 |
| WO2021219710A1 (en) | 2020-04-29 | 2021-11-04 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
| JP2023542867A (ja) | 2020-09-11 | 2023-10-12 | グリンプス バイオ， インコーポレイテッド | 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出 |
| WO2022068920A1 (en) | 2020-09-30 | 2022-04-07 | Beijing Ql Biopharmaceutical Co., Ltd. | Polypeptide conjugates and methods of uses |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| JP2025512832A (ja) | 2022-03-30 | 2025-04-22 | ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド | ポリペプチドコンジュゲートの液体医薬組成物およびその使用の方法 |
| WO2024110614A1 (en) | 2022-11-25 | 2024-05-30 | Novo Nordisk A/S | Oral administration of peptide therapeutics, such as glp-1 |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DK0944648T3 (da) * | 1996-08-30 | 2007-07-02 | Novo Nordisk As | GLP-1 derivater |
| AU3247799A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| JP2002512175A (ja) | 1998-02-27 | 2002-04-23 | ノボ ノルディスク アクティーゼルスカブ | Ｇｌｐ−１類似体の誘導体類 |
| AU762012B2 (en) | 1998-12-07 | 2003-06-19 | Ipsen Pharma S.A.S. | Analogues of GLP-1 |
| EP1239871A1 (en) | 1999-11-12 | 2002-09-18 | Novo Nordisk A/S | Use of glp-1 agonists for the inhibition of beta cell degeneration |
| US6693094B2 (en) * | 2001-03-22 | 2004-02-17 | Chrono Rx Llc | Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus |
| JPWO2004037859A1 (ja) * | 2002-10-11 | 2006-02-23 | 株式会社三和化学研究所 | Ｇｌｐ−１誘導体及びその経粘膜吸収型製剤 |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| EP2190460B1 (en) | 2007-09-05 | 2014-12-17 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| WO2011073328A1 (en) * | 2009-12-16 | 2011-06-23 | Novo Nordisk A/S | Glp-1 receptor agonist compounds with a modified n-terminus |
| WO2012062803A1 (en) | 2010-11-09 | 2012-05-18 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| CN103298456A (zh) * | 2011-01-19 | 2013-09-11 | 诺沃—诺迪斯克有限公司 | Glp-1颗粒和组合物 |
| EP3225631B1 (en) * | 2011-04-12 | 2019-01-09 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| ES2626013T3 (es) * | 2011-09-06 | 2017-07-21 | Novo Nordisk A/S | Derivados de GLP-1 |
| EP2846824B1 (en) * | 2012-05-08 | 2017-04-05 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| JP6250034B2 (ja) * | 2012-05-08 | 2017-12-20 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| CN105073129A (zh) * | 2013-01-29 | 2015-11-18 | 奥莎迪药品管理有限公司 | 用于糖尿病的口服治疗的药物组合物 |
-
2015
- 2015-04-07 CN CN201580018073.6A patent/CN106132985B/zh active Active
- 2015-04-07 ES ES15713772T patent/ES2741507T3/es active Active
- 2015-04-07 WO PCT/EP2015/057442 patent/WO2015155151A1/en not_active Ceased
- 2015-04-07 JP JP2016561311A patent/JP6768515B2/ja active Active
- 2015-04-07 EP EP15713772.0A patent/EP3129041B1/en active Active
- 2015-04-07 US US15/301,960 patent/US10689429B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106132985B (zh) | 2020-10-13 |
| CN106132985A (zh) | 2016-11-16 |
| WO2015155151A1 (en) | 2015-10-15 |
| US10689429B2 (en) | 2020-06-23 |
| EP3129041B1 (en) | 2019-06-12 |
| US20170114116A1 (en) | 2017-04-27 |
| EP3129041A1 (en) | 2017-02-15 |
| ES2741507T3 (es) | 2020-02-11 |
| JP2017514801A (ja) | 2017-06-08 |
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