JP6768515B2 - 二重アシル化ｇｌｐ−１化合物 - Google Patents
二重アシル化ｇｌｐ−１化合物 Download PDFInfo
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- JP6768515B2 JP6768515B2 JP2016561311A JP2016561311A JP6768515B2 JP 6768515 B2 JP6768515 B2 JP 6768515B2 JP 2016561311 A JP2016561311 A JP 2016561311A JP 2016561311 A JP2016561311 A JP 2016561311A JP 6768515 B2 JP6768515 B2 JP 6768515B2
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- A61K38/00—Medicinal preparations containing peptides
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| EP14163697 | 2014-04-07 | ||
| EP14163697.7 | 2014-04-07 | ||
| PCT/EP2015/057442 WO2015155151A1 (en) | 2014-04-07 | 2015-04-07 | Double-acylated glp-1 compounds |
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| JP2017514801A JP2017514801A (ja) | 2017-06-08 |
| JP2017514801A5 JP2017514801A5 (enExample) | 2018-05-10 |
| JP6768515B2 true JP6768515B2 (ja) | 2020-10-14 |
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| EP (1) | EP3129041B1 (enExample) |
| JP (1) | JP6768515B2 (enExample) |
| CN (1) | CN106132985B (enExample) |
| ES (1) | ES2741507T3 (enExample) |
| WO (1) | WO2015155151A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| WO2017149070A1 (en) | 2016-03-03 | 2017-09-08 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
| TWI797133B (zh) | 2017-06-09 | 2023-04-01 | 丹麥商諾佛 儂迪克股份有限公司 | 用於經口投予的固體組成物 |
| CN111050750B (zh) | 2017-08-24 | 2024-09-24 | 诺和诺德股份有限公司 | Glp-1组合物及其用途 |
| EP4299118A3 (en) | 2018-02-02 | 2024-04-10 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
| WO2019200594A1 (zh) * | 2018-04-19 | 2019-10-24 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| WO2020077129A1 (en) | 2018-10-11 | 2020-04-16 | Intarcia Therapeutics, Inc. | Human amylin analog polypeptides and methods of use |
| CN111378027B (zh) * | 2018-12-29 | 2022-04-15 | 万新医药科技(苏州)有限公司 | 一种索玛鲁肽前体的制备方法 |
| JP7767264B2 (ja) * | 2019-09-02 | 2025-11-11 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１ペプチドを含む錠剤を生成するためのプロセス |
| JP7670698B2 (ja) | 2019-11-06 | 2025-04-30 | ノヴォ ノルディスク アー／エス | 認知症におけるｇｌｐ－１受容体作動薬 |
| EP4054536A1 (en) | 2019-11-07 | 2022-09-14 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| JP7761567B2 (ja) | 2020-02-18 | 2025-10-28 | ノヴォ ノルディスク アー／エス | 医薬製剤 |
| US20230165939A1 (en) | 2020-04-29 | 2023-06-01 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
| WO2022056313A2 (en) * | 2020-09-11 | 2022-03-17 | Glympse Bio, Inc. | Ex vivo protease activity detection for disease detection/diagnostic, staging, monitoring and treatment |
| EP4222176A4 (en) | 2020-09-30 | 2024-02-28 | Beijing QL Biopharmaceutical Co., Ltd. | POLYPEPTIDE CONJUGATES AND METHODS OF USE |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| KR20240163717A (ko) | 2022-03-30 | 2024-11-19 | 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 | 폴리펩티드 접합체의 액체 약학 조성물 및 그의 사용 방법 |
| TW202421645A (zh) | 2022-11-25 | 2024-06-01 | 丹麥商諾佛 儂迪克股份有限公司 | 如ｇｌｐ—１之肽治療劑的口服投與 |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
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| CA2264243C (en) * | 1996-08-30 | 2004-10-05 | Novo Nordisk A/S | Glp-1 derivatives |
| AU2610699A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Derivatives of glp-1 analogs |
| WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| CN1495198A (zh) | 1998-12-07 | 2004-05-12 | �о���Ӧ�ÿ�ѧЭ��ɷ�����˾ | 胰高血糖素样肽-1的类似物 |
| EP1239871A1 (en) | 1999-11-12 | 2002-09-18 | Novo Nordisk A/S | Use of glp-1 agonists for the inhibition of beta cell degeneration |
| US6693094B2 (en) * | 2001-03-22 | 2004-02-17 | Chrono Rx Llc | Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus |
| US7291594B2 (en) | 2002-10-11 | 2007-11-06 | Sanwa Kagaku Kenkyusho Co., Ltd. | GLP-1 derivative and preparation thereof absorbable via mucous membrane |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| CN101842109B (zh) | 2007-09-05 | 2014-01-29 | 诺沃-诺迪斯克有限公司 | 用a-b-c-d-衍生的肽和它们的治疗用途 |
| CN111560060A (zh) * | 2009-12-16 | 2020-08-21 | 诺沃—诺迪斯克有限公司 | 双酰化glp-1衍生物 |
| CN105601729A (zh) * | 2010-11-09 | 2016-05-25 | 诺沃—诺迪斯克有限公司 | 双-酰化的glp-1衍生物 |
| CN103298456A (zh) * | 2011-01-19 | 2013-09-11 | 诺沃—诺迪斯克有限公司 | Glp-1颗粒和组合物 |
| KR101972836B1 (ko) * | 2011-04-12 | 2019-04-29 | 노보 노르디스크 에이/에스 | 이중 아실화된 ｇｌｐ-1 유도체 |
| ES2626013T3 (es) * | 2011-09-06 | 2017-07-21 | Novo Nordisk A/S | Derivados de GLP-1 |
| JP6366575B2 (ja) * | 2012-05-08 | 2018-08-01 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| EP2846823B1 (en) | 2012-05-08 | 2019-12-04 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| AU2014210751A1 (en) * | 2013-01-29 | 2015-08-06 | Oshadi Drug Administration Ltd. | Pharmaceutical compositions for oral treatment of diabetes |
-
2015
- 2015-04-07 CN CN201580018073.6A patent/CN106132985B/zh active Active
- 2015-04-07 JP JP2016561311A patent/JP6768515B2/ja active Active
- 2015-04-07 EP EP15713772.0A patent/EP3129041B1/en active Active
- 2015-04-07 ES ES15713772T patent/ES2741507T3/es active Active
- 2015-04-07 WO PCT/EP2015/057442 patent/WO2015155151A1/en not_active Ceased
- 2015-04-07 US US15/301,960 patent/US10689429B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170114116A1 (en) | 2017-04-27 |
| WO2015155151A1 (en) | 2015-10-15 |
| EP3129041B1 (en) | 2019-06-12 |
| ES2741507T3 (es) | 2020-02-11 |
| JP2017514801A (ja) | 2017-06-08 |
| EP3129041A1 (en) | 2017-02-15 |
| CN106132985A (zh) | 2016-11-16 |
| CN106132985B (zh) | 2020-10-13 |
| US10689429B2 (en) | 2020-06-23 |
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