ES2723437T3 - Procesos y productos intermedios para la preparación de un inhibidor de PDE10 - Google Patents
Procesos y productos intermedios para la preparación de un inhibidor de PDE10 Download PDFInfo
- Publication number
- ES2723437T3 ES2723437T3 ES15785376T ES15785376T ES2723437T3 ES 2723437 T3 ES2723437 T3 ES 2723437T3 ES 15785376 T ES15785376 T ES 15785376T ES 15785376 T ES15785376 T ES 15785376T ES 2723437 T3 ES2723437 T3 ES 2723437T3
- Authority
- ES
- Spain
- Prior art keywords
- converting
- formula
- acid
- compound
- metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002184 metal Substances 0.000 abstract 3
- 229910052751 metal Inorganic materials 0.000 abstract 3
- GPWNWKWQOLEVEQ-UHFFFAOYSA-N 2,4-diaminopyrimidine-5-carbaldehyde Chemical compound NC1=NC=C(C=O)C(N)=N1 GPWNWKWQOLEVEQ-UHFFFAOYSA-N 0.000 abstract 2
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000007171 acid catalysis Methods 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000007825 activation reagent Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 238000007333 cyanation reaction Methods 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/02—Lithium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461985400P | 2014-04-28 | 2014-04-28 | |
| PCT/US2015/027647 WO2015167969A1 (en) | 2014-04-28 | 2015-04-24 | Processes and intermediates for the preparation of a pde10 inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2723437T3 true ES2723437T3 (es) | 2019-08-27 |
Family
ID=54359190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15785376T Active ES2723437T3 (es) | 2014-04-28 | 2015-04-24 | Procesos y productos intermedios para la preparación de un inhibidor de PDE10 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9650368B2 (show.php) |
| EP (1) | EP3137462B1 (show.php) |
| JP (1) | JP6474430B2 (show.php) |
| KR (1) | KR102496552B1 (show.php) |
| CN (1) | CN106459026B (show.php) |
| AU (1) | AU2015253464B2 (show.php) |
| BR (1) | BR112016025287B1 (show.php) |
| CA (1) | CA2946756C (show.php) |
| ES (1) | ES2723437T3 (show.php) |
| IL (1) | IL248585B (show.php) |
| NZ (2) | NZ716494A (show.php) |
| RU (1) | RU2718863C2 (show.php) |
| WO (1) | WO2015167969A1 (show.php) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339950B (es) * | 2010-03-12 | 2016-06-20 | Omeros Corp | Inhibidores de fosfodiesterasa 10 (pde10) y composiciones y metodos relacionados. |
| NZ630803A (en) * | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
| JP2018535969A (ja) | 2015-11-04 | 2018-12-06 | オメロス コーポレーション | Ｐｄｅ１０阻害剤の固体状態形態 |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK178590D0 (da) | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| ES2192192T3 (es) | 1992-12-02 | 2003-10-01 | Pfizer | Dieteres de catecol como inhibidores selectivos de pde iv. |
| DE4323192A1 (de) | 1993-07-10 | 1995-01-12 | Basf Ag | Verfahren zur Herstellung von Homo- und Copolymerisaten von Alk-1-enen |
| DE4325846C1 (de) | 1993-07-31 | 1995-01-19 | Herberts Gmbh | Verwendung von Furan-modifizierten aromatischen Pinakolderivaten als Initiatoren und Furan-modifizierte aromatische Pinakolderivate als solche |
| DE4343286A1 (de) | 1993-12-17 | 1995-06-22 | Hoechst Ag | Heteroaromatische Verbindungen und ihre Verwendung in flüssigkristallinen Mischungen |
| DE4409501A1 (de) | 1994-03-19 | 1995-09-21 | Didier Werke Ag | Verschleißfutter eines Schachtofens und Stein hierfür |
| WO1996000218A1 (en) | 1994-06-24 | 1996-01-04 | Euro-Celtique, S.A. | Compounds for and method of inhibiting phosphodiesterase iv |
| US5789434A (en) | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| TW424087B (en) | 1995-04-06 | 2001-03-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives |
| TW332201B (en) | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
| US6037370A (en) | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| DE69712042T2 (de) | 1996-01-22 | 2002-10-02 | Fujisawa Pharmaceutical Co., Ltd. | Thiazolylbenzofuranderivate und pharmazeutische zusammensetzungen die sie enthalten |
| AU4015497A (en) | 1996-08-26 | 1998-03-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thiazole derivatives useful as selective inhibitors of pde-iv |
| JPH1087543A (ja) | 1996-09-17 | 1998-04-07 | Chisso Corp | アルコキシベンゼン誘導体、液晶組成物および液晶表示素子 |
| US6548490B1 (en) | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| WO1999045914A1 (en) | 1998-03-13 | 1999-09-16 | Maruho Kabushikikaisha | Alkyl amine derivative and local anesthetic agent using the same |
| GB9807354D0 (en) | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
| SE9804212D0 (sv) | 1998-12-04 | 1998-12-04 | Astra Pharma Prod | Compounds |
| HK1043127B (zh) | 1999-03-12 | 2004-12-24 | 贝林格尔‧英格海姆药物公司 | 作为消炎剂的化合物 |
| US7141593B1 (en) | 1999-06-04 | 2006-11-28 | Abbott Laboratories | Pharmaceutical formulations |
| GB9929552D0 (en) | 1999-12-14 | 2000-02-09 | Proteus Molecular Design | Compounds |
| US6933304B2 (en) | 2000-06-15 | 2005-08-23 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| PL367091A1 (en) | 2001-05-22 | 2005-02-21 | Pfizer Products Inc. | Crystal forms of azithromycin |
| US20050165185A1 (en) * | 2002-04-18 | 2005-07-28 | Spivey Alan C. | Preparation of a conjugated molecule and materials for use therein |
| US6821502B2 (en) | 2002-06-12 | 2004-11-23 | Chevron U.S.A. Inc. | Method of making aluminum-containing zeolite with IFR structure |
| AU2003254481A1 (en) | 2002-07-27 | 2004-02-16 | Astrazeneca Ab | Chemical compounds |
| JP4628789B2 (ja) | 2002-10-08 | 2011-02-09 | ザ スクリプス リサーチ インスティテュート | 脂肪酸アミド加水分解酵素の阻害剤 |
| JP2006509832A (ja) | 2002-10-30 | 2006-03-23 | ニューロ３デー | サイクリックヌクレオチドホスホジエステラーゼ阻害剤、その調製及び使用 |
| TW200410921A (en) | 2002-11-25 | 2004-07-01 | Hoffmann La Roche | Mandelic acid derivatives |
| JP4464280B2 (ja) | 2002-12-06 | 2010-05-19 | 興和株式会社 | エリスロポエチン産生促進剤 |
| CA2507699A1 (en) | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
| WO2004071509A1 (ja) | 2003-02-12 | 2004-08-26 | Nippon Chemiphar Co., Ltd. | オリゴデンドロサイト分化促進剤 |
| AU2004232973A1 (en) | 2003-04-18 | 2004-11-04 | Memory Pharmaceuticals Corporation | Pyrazole derivatives as phosphodiesterase 4 inhibitors |
| AR047541A1 (es) | 2004-02-13 | 2006-01-25 | Sandoz Ag | Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas |
| CN1946703A (zh) | 2004-04-20 | 2007-04-11 | 特兰斯泰克制药公司 | 取代的噻唑和嘧啶衍生物作为黑素细胞皮质激素受体调节剂 |
| WO2005110410A2 (en) * | 2004-05-14 | 2005-11-24 | Abbott Laboratories | Kinase inhibitors as therapeutic agents |
| US7351833B2 (en) | 2004-07-23 | 2008-04-01 | Abbott Laboratories | (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate |
| US7449486B2 (en) * | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| US8436176B2 (en) | 2004-12-30 | 2013-05-07 | Medicis Pharmaceutical Corporation | Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine |
| RS51385B (sr) | 2005-01-07 | 2011-02-28 | Pfizer Products Inc. | Heteroaromatična jedinjenja hinolina i njihova upotreba kao pde10 inhibitora |
| CN101384183B (zh) | 2005-02-04 | 2012-07-04 | 西诺米克斯公司 | 包含连接有杂芳基部分的化合物及其作为用于食物组合物的新型鲜味调节剂、促味剂和味觉增强剂的应用 |
| EP1871770A1 (en) | 2005-04-22 | 2008-01-02 | Kalypsys, Inc. | Ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders |
| UA91546C2 (uk) | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
| MY152185A (en) | 2005-06-10 | 2014-08-29 | Novartis Ag | Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation |
| CA2617788A1 (en) | 2005-08-04 | 2007-02-15 | Apogee Biotechnology Corporation | Sphingosine kinase inhibitors and methods of their use |
| ES2375841T3 (es) | 2005-08-29 | 2012-03-06 | Sanofi-Aventis U.S. Llc | Nueva forma cristalina de un derivado de piridazino[4,5-b]indol. |
| US7642246B2 (en) | 2005-09-13 | 2010-01-05 | Sicor Inc. | Pure rocuronium bromide |
| KR101439557B1 (ko) | 2005-11-15 | 2014-09-11 | 오츠카 세이야쿠 가부시키가이샤 | 옥사졸 화합물 및 제약 조성물 |
| JP2009521429A (ja) | 2005-12-23 | 2009-06-04 | アストラゼネカ・アクチエボラーグ | Ｇａｂａ−ｂ受容体モジュレーターとしてのイミダゾール |
| US20090176829A1 (en) | 2006-05-02 | 2009-07-09 | Pfizer Inc | Bicyclic heteroaryl compounds as pde10 inhibitors |
| US20080090834A1 (en) | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
| CA2662535A1 (en) | 2006-09-08 | 2008-03-13 | Ore Pharmaceuticals Inc. | Method for reducing or alleviating inflammation in the digestive tract |
| WO2008039431A2 (en) | 2006-09-25 | 2008-04-03 | Ptc Therapeutics, Inc. | Crystalline forms of 3-[5-(2-fhjorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid |
| CN101528212A (zh) | 2006-09-28 | 2009-09-09 | 默克公司 | Hdac抑制剂和可螯合的金属化合物的药物组合物以及金属-hdac抑制剂螯合物 |
| US20090253918A1 (en) | 2006-10-02 | 2009-10-08 | Janssen Pharmaceuticals, N.V. | Novel intermediate for glyt1 inhibitor |
| US7837978B2 (en) | 2006-10-13 | 2010-11-23 | Chevron U.S.A. Inc. | Process for preparing aluminum-containing molecular sieve SSZ-26 |
| US7786139B2 (en) * | 2006-11-21 | 2010-08-31 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| WO2008064342A2 (en) * | 2006-11-21 | 2008-05-29 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| PE20081506A1 (es) | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| WO2009008906A2 (en) | 2007-02-06 | 2009-01-15 | The Trustees Of The University Of Pennsylvania | Therapeutic compounds for blocking dna synthesis of pox viruses |
| EP2160394A1 (en) | 2007-05-22 | 2010-03-10 | Ultimorphix Technologies B.v. | Tenofovir disoproxil hemi-fumaric acid co-crystal |
| EP2017264A1 (de) | 2007-07-16 | 2009-01-21 | Bayer Cropscience Ag | Substituierte Phenylpropargylverbindungen, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| US20090186014A1 (en) | 2007-10-10 | 2009-07-23 | Ore Pharmaceuticals Inc. | Method for treatment of pancreatitis |
| TW200944520A (en) | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| WO2009143178A2 (en) | 2008-05-20 | 2009-11-26 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| US8377930B2 (en) | 2008-08-05 | 2013-02-19 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| MX339950B (es) * | 2010-03-12 | 2016-06-20 | Omeros Corp | Inhibidores de fosfodiesterasa 10 (pde10) y composiciones y metodos relacionados. |
| NZ630803A (en) * | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
-
2014
- 2014-09-10 NZ NZ716494A patent/NZ716494A/en unknown
- 2014-09-10 NZ NZ630810A patent/NZ630810A/en unknown
-
2015
- 2015-04-24 CN CN201580023525.XA patent/CN106459026B/zh active Active
- 2015-04-24 BR BR112016025287-0A patent/BR112016025287B1/pt active IP Right Grant
- 2015-04-24 EP EP15785376.3A patent/EP3137462B1/en active Active
- 2015-04-24 KR KR1020167032983A patent/KR102496552B1/ko active Active
- 2015-04-24 RU RU2016146118A patent/RU2718863C2/ru active
- 2015-04-24 ES ES15785376T patent/ES2723437T3/es active Active
- 2015-04-24 CA CA2946756A patent/CA2946756C/en active Active
- 2015-04-24 AU AU2015253464A patent/AU2015253464B2/en active Active
- 2015-04-24 JP JP2016564031A patent/JP6474430B2/ja active Active
- 2015-04-24 US US14/696,287 patent/US9650368B2/en active Active
- 2015-04-24 WO PCT/US2015/027647 patent/WO2015167969A1/en not_active Ceased
-
2016
- 2016-10-27 IL IL248585A patent/IL248585B/en active IP Right Grant
-
2017
- 2017-04-07 US US15/482,604 patent/US20180057484A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US9650368B2 (en) | 2017-05-16 |
| WO2015167969A1 (en) | 2015-11-05 |
| US20180057484A1 (en) | 2018-03-01 |
| EP3137462B1 (en) | 2019-01-30 |
| US20160024069A1 (en) | 2016-01-28 |
| RU2016146118A3 (show.php) | 2018-12-24 |
| IL248585A0 (en) | 2016-12-29 |
| EP3137462A4 (en) | 2017-12-27 |
| CN106459026A (zh) | 2017-02-22 |
| JP6474430B2 (ja) | 2019-02-27 |
| NZ630810A (en) | 2016-03-31 |
| CA2946756C (en) | 2022-03-29 |
| BR112016025287B1 (pt) | 2022-10-11 |
| RU2016146118A (ru) | 2018-05-30 |
| BR112016025287A2 (pt) | 2017-08-15 |
| AU2015253464A1 (en) | 2016-10-27 |
| KR102496552B1 (ko) | 2023-02-06 |
| KR20160147275A (ko) | 2016-12-22 |
| NZ716494A (en) | 2017-07-28 |
| EP3137462A1 (en) | 2017-03-08 |
| AU2015253464B2 (en) | 2018-11-22 |
| CN106459026B (zh) | 2019-07-05 |
| RU2718863C2 (ru) | 2020-04-15 |
| IL248585B (en) | 2020-03-31 |
| CA2946756A1 (en) | 2015-11-05 |
| JP2017513885A (ja) | 2017-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX350892B (es) | Síntesis de compuesto antiviral. | |
| MX346922B (es) | Moderación de suciedad en procesos de hidroformilación mediante adición de agua. | |
| SA515370018B1 (ar) | مركب سائل أيوني | |
| MY172419A (en) | Hydroformylation process | |
| AR105494A1 (es) | Método para preparar derivados de ácido 3-(2-anilino-1-ciclohexil-1h-bencimidazol-5-il)propanoico sustituido | |
| NZ718607A (en) | Synthetic route to 2’-deoxy-2’,2’-difluorotetrahydrouridines | |
| BR112016008895A8 (pt) | métodos para formação de compostos homoalílicos pela reação de precursores de ciclopropilvinila com ácido de bronsted, e para formação de ambrox | |
| ES2723437T3 (es) | Procesos y productos intermedios para la preparación de un inhibidor de PDE10 | |
| AR084864A1 (es) | Proceso de preparacion de girasa e inhibidores de topoisomerasa iv y compuestos intermediarios de dicho proceso | |
| MX2022014035A (es) | Proceso para la ciclopropanacion de olefinas utilizando compuestos de n-metil-n-nitroso. | |
| MX2015013589A (es) | Proceso e intermediario para la preparacion de pregabalina. | |
| BR112015018018A2 (pt) | Processo para a preparação de hidróxi aldeído | |
| NZ716462A (en) | Optically active pde10 inhibitor | |
| IN2015DN00665A (show.php) | ||
| MY194792A (en) | Method for producing optically active 2-(2-fluorobiphenyl-4-yl) propanoic acid | |
| TN2014000329A1 (en) | Method for preparing compound by novel michael addition reaction using water or various acids as additive | |
| EA028190B9 (ru) | Монооксид азота в качестве катализатора цис/транс-изомеризации ненасыщенных соединений | |
| GB2523674A (en) | Compounds as inhibitor of DNA double-strand break repair, methods and applications thereof | |
| AR106195A1 (es) | Proceso para la preparación de ácido 1-(4-metanosulfonil-2-trifluorometil-bencil)-2-metil-1h-pirrolo[2,3-b]piridin-3-il-acético e intermediarios de dicha síntesis | |
| BR112017006795A2 (pt) | método para acoplamento de um composto fluorossulfonato com um composto amina | |
| ES2721446T3 (es) | Método para producir un compuesto de éster del ácido ciclopropano carboxílico ópticamente activo, un complejo de cobre asimétrico y un compuesto de salicilidenoaminoalcohol ópticamente activo | |
| MD20140048A2 (ru) | Способ синтеза 3,4-диметоксибицикло¢4.2.0]окта-1,3,5-триен-7-карбонитрила и его применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей | |
| MX2017003290A (es) | Proceso para la preparacion de derivados de trifenilbuteno. | |
| MY156194A (en) | Method for producing or method for storing liquid composition containing tetrahydro-4h-1,3,5-oxadiazin-4-one | |
| MX2013011604A (es) | Metodo para la remocion del diester ciclico de un acido 2-hidroxialcanoico de un vapor. |