ES2714576T3 - Oxido de arilfósforo y sulfuro de arilfósforo espirocíclicos - Google Patents
Oxido de arilfósforo y sulfuro de arilfósforo espirocíclicos Download PDFInfo
- Publication number
- ES2714576T3 ES2714576T3 ES15814466T ES15814466T ES2714576T3 ES 2714576 T3 ES2714576 T3 ES 2714576T3 ES 15814466 T ES15814466 T ES 15814466T ES 15814466 T ES15814466 T ES 15814466T ES 2714576 T3 ES2714576 T3 ES 2714576T3
- Authority
- ES
- Spain
- Prior art keywords
- mmol
- amino
- methoxy
- phenyl
- diazaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC*CCOI(*)N Chemical compound CC*CCOI(*)N 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65615—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing a spiro condensed ring system of the formula where at least one of the atoms X or Y is a hetero atom, e.g. S
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410317076.7A CN105330698B (zh) | 2014-07-04 | 2014-07-04 | 螺环芳基磷氧化物和硫化物 |
| CN201510350019 | 2015-06-23 | ||
| PCT/CN2015/082605 WO2016000581A1 (zh) | 2014-07-04 | 2015-06-29 | 螺环芳基磷氧化物和芳基磷硫化物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2714576T3 true ES2714576T3 (es) | 2019-05-29 |
Family
ID=55018447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15814466T Active ES2714576T3 (es) | 2014-07-04 | 2015-06-29 | Oxido de arilfósforo y sulfuro de arilfósforo espirocíclicos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10053477B2 (enExample) |
| EP (1) | EP3165530B1 (enExample) |
| JP (1) | JP6487527B2 (enExample) |
| ES (1) | ES2714576T3 (enExample) |
| PL (1) | PL3165530T3 (enExample) |
| TW (1) | TWI571471B (enExample) |
| WO (1) | WO2016000581A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6487527B2 (ja) | 2014-07-04 | 2019-03-20 | チル ファーマシューティカル カンパニー リミテッド | スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ） |
| JP6717457B2 (ja) | 2017-01-23 | 2020-07-01 | シージャーズォアン サガシティ ニュー ドラッグ デベロップメント カンパニー リミテッド | Ｗｅｅ１阻害剤としての１，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン誘導体 |
| CN110944999A (zh) * | 2017-08-01 | 2020-03-31 | 勃林格殷格翰国际有限公司 | 中间体化合物和方法 |
| US20210009613A1 (en) * | 2017-12-12 | 2021-01-14 | Shenzhen Targetrx, Inc. | Arylphosphine oxides for inhibiting kinase activity |
| EP3715343B1 (en) * | 2017-12-21 | 2024-02-14 | Shenzhen TargetRx, Inc. | Diphenylaminopyrimidine compound for inhibiting kinase activity |
| WO2019201334A1 (zh) * | 2018-04-20 | 2019-10-24 | 南京明德新药研发有限公司 | 二甲基氧膦类化合物 |
| WO2020147702A1 (en) * | 2019-01-17 | 2020-07-23 | Betta Pharmaceuticals Co., Ltd | Egfr inhibitors, compositions and methods thereof |
| UY38988A (es) | 2019-12-19 | 2021-06-30 | Janssen Pharmaceutica Nv | Derivados espiráncos sustituidos de cadena lineal |
| JP7671362B2 (ja) * | 2021-07-05 | 2025-05-01 | チールー ファーマシューティカル カンパニー、リミテッド | 医薬組成物、その製造方法及び使用 |
| WO2023078411A1 (zh) * | 2021-11-05 | 2023-05-11 | 南京明德新药研发有限公司 | 氮杂螺环化合物 |
| WO2023138574A1 (zh) * | 2022-01-18 | 2023-07-27 | 齐鲁制药有限公司 | 螺环芳基磷氧化物与抗vegf抗体的药物组合 |
| WO2023138576A1 (zh) * | 2022-01-18 | 2023-07-27 | 齐鲁制药有限公司 | 螺环芳基磷氧化物与抗egfr抗体的药物组合 |
| CN118891264A (zh) * | 2022-08-01 | 2024-11-01 | 齐鲁制药有限公司 | 螺环胺类芳基磷氧化合物的晶型及其制备方法 |
| UY41082A (es) | 2024-03-28 | 2025-08-29 | Pi Industries Ltd | Compuestos bicíclicos condensados y su uso como agentes de control de plagas |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| TWI389893B (zh) * | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二（芳胺基）芳基化合物 |
| JP2011523646A (ja) | 2008-05-21 | 2011-08-18 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのリン誘導体 |
| US9273077B2 (en) * | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| CA2778265A1 (en) * | 2009-11-02 | 2011-05-05 | Abbott Laboratories | Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition |
| WO2011146945A2 (en) * | 2010-05-21 | 2011-11-24 | Cell Signaling Technology, Inc. | Alk and ros kinase in cancer |
| KR20130139999A (ko) | 2010-10-14 | 2013-12-23 | 어리어드 파마슈티칼스, 인코포레이티드 | Egfr-유도된 암의 세포 증식을 억제하는 방법 |
| FR2974088A1 (fr) | 2011-04-12 | 2012-10-19 | Pf Medicament | Composes pyrazolo[3,4-b]pyridines tri- et tetracycliques comme agent anticancereux |
| CN102731413A (zh) | 2011-04-15 | 2012-10-17 | 上海医药工业研究院 | 一种脲类化合物、其制备方法、其中间体及其应用 |
| WO2013138210A1 (en) | 2012-03-14 | 2013-09-19 | Ning Xi | Substituted cyclic compounds and methods of use |
| CA2868258A1 (en) | 2012-03-28 | 2013-10-03 | Synta Pharmaceuticals Corp. | Triazole derivatives as hsp90 inhibitors |
| JP6469567B2 (ja) * | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| US20130310340A1 (en) * | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| WO2013177092A1 (en) | 2012-05-23 | 2013-11-28 | Sunshine Lake Pharma Co., Ltd. | Substituted alkynyl pyridine compounds and methods of use |
| WO2013192512A1 (en) | 2012-06-22 | 2013-12-27 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
| WO2014002922A1 (ja) | 2012-06-26 | 2014-01-03 | アステラス製薬株式会社 | 抗癌剤の併用による癌治療方法 |
| EP2867233A1 (en) | 2012-07-03 | 2015-05-06 | Aurigene Discovery Technologies Limited | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS |
| KR101446742B1 (ko) | 2012-08-10 | 2014-10-01 | 한국화학연구원 | Ｎ2,ｎ4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| JP2015529665A (ja) | 2012-08-27 | 2015-10-08 | ツェーエムエム−フォルシュングスツェントルム フュア モレクラレ メディツィン ゲーエムベーハー | Ｍｔｈ１阻害剤としてのアミノヘテロアリール化合物 |
| JP6487527B2 (ja) | 2014-07-04 | 2019-03-20 | チル ファーマシューティカル カンパニー リミテッド | スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ） |
-
2015
- 2015-06-29 JP JP2017501154A patent/JP6487527B2/ja active Active
- 2015-06-29 ES ES15814466T patent/ES2714576T3/es active Active
- 2015-06-29 US US15/322,854 patent/US10053477B2/en active Active
- 2015-06-29 PL PL15814466T patent/PL3165530T3/pl unknown
- 2015-06-29 WO PCT/CN2015/082605 patent/WO2016000581A1/zh not_active Ceased
- 2015-06-29 EP EP15814466.7A patent/EP3165530B1/en active Active
- 2015-07-01 TW TW104121403A patent/TWI571471B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016000581A1 (zh) | 2016-01-07 |
| EP3165530B1 (en) | 2018-12-05 |
| US10053477B2 (en) | 2018-08-21 |
| US20170129909A1 (en) | 2017-05-11 |
| PL3165530T3 (pl) | 2019-07-31 |
| EP3165530A4 (en) | 2017-07-26 |
| JP6487527B2 (ja) | 2019-03-20 |
| TWI571471B (zh) | 2017-02-21 |
| EP3165530A1 (en) | 2017-05-10 |
| TW201604202A (zh) | 2016-02-01 |
| JP2017521436A (ja) | 2017-08-03 |
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