JP6487527B2 - スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ） - Google Patents

スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ） Download PDF

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JP6487527B2
JP6487527B2 JP2017501154A JP2017501154A JP6487527B2 JP 6487527 B2 JP6487527 B2 JP 6487527B2 JP 2017501154 A JP2017501154 A JP 2017501154A JP 2017501154 A JP2017501154 A JP 2017501154A JP 6487527 B2 JP6487527 B2 JP 6487527B2
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diazaspiro
amino
mmol
group
methoxy
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JP2017521436A5 (enExample
JP2017521436A (ja
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ジャオジョン ディン
ジャオジョン ディン
ミンフイ ジャン
ミンフイ ジャン
シュフイ チェン
シュフイ チェン
シル リュウ
シル リュウ
イドン ジュ
イドン ジュ
ツアンウエン ファン
ツアンウエン ファン
バオピン ジャオ
バオピン ジャオ
ロン ジャン
ロン ジャン
インイン ヤン
インイン ヤン
チンメイ ジェン
チンメイ ジェン
シャンソン ジェン
シャンソン ジェン
ハイウエン ワン
ハイウエン ワン
ジンチン フ
ジンチン フ
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チル ファーマシューティカル カンパニー リミテッド
チル ファーマシューティカル カンパニー リミテッド
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Priority claimed from CN201410317076.7A external-priority patent/CN105330698B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65615—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing a spiro condensed ring system of the formula where at least one of the atoms X or Y is a hetero atom, e.g. S

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2017501154A 2014-07-04 2015-06-29 スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ） Active JP6487527B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201410317076.7 2014-07-04
CN201410317076.7A CN105330698B (zh) 2014-07-04 2014-07-04 螺环芳基磷氧化物和硫化物
CN201510350019.3 2015-06-23
CN201510350019 2015-06-23
PCT/CN2015/082605 WO2016000581A1 (zh) 2014-07-04 2015-06-29 螺环芳基磷氧化物和芳基磷硫化物

Publications (3)

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JP2017521436A JP2017521436A (ja) 2017-08-03
JP2017521436A5 JP2017521436A5 (enExample) 2019-02-14
JP6487527B2 true JP6487527B2 (ja) 2019-03-20

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JP2017501154A Active JP6487527B2 (ja) 2014-07-04 2015-06-29 スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ）

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US (1) US10053477B2 (enExample)
EP (1) EP3165530B1 (enExample)
JP (1) JP6487527B2 (enExample)
ES (1) ES2714576T3 (enExample)
PL (1) PL3165530T3 (enExample)
TW (1) TWI571471B (enExample)
WO (1) WO2016000581A1 (enExample)

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JP6487527B2 (ja) 2014-07-04 2019-03-20 チル ファーマシューティカル カンパニー リミテッド スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ）
JP6717457B2 (ja) 2017-01-23 2020-07-01 シージャーズォアン サガシティ ニュー ドラッグ デベロップメント カンパニー リミテッド Ｗｅｅ１阻害剤としての１，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン誘導体
WO2019027860A1 (en) * 2017-08-01 2019-02-07 Boehringer Ingelheim International Gmbh INTERMEDIATE COMPOUNDS AND METHODS
JP7085242B2 (ja) * 2017-12-21 2022-06-16 深▲チェン▼市塔吉瑞生物医薬有限公司 キナーゼ活性を阻害するためのアリールホスフィンオキシド
EP3715343B1 (en) * 2017-12-21 2024-02-14 Shenzhen TargetRx, Inc. Diphenylaminopyrimidine compound for inhibiting kinase activity
JP7138768B2 (ja) * 2018-04-20 2022-09-16 ▲貴▼州伊▲諾▼其尼科技有限公司 ジメチルホスフィンオキシド化合物
WO2020147702A1 (en) * 2019-01-17 2020-07-23 Betta Pharmaceuticals Co., Ltd Egfr inhibitors, compositions and methods thereof
TW202525813A (zh) 2019-12-19 2025-07-01 比利時商健生藥品公司 經取代之直鏈螺環接衍生物
JP7671362B2 (ja) * 2021-07-05 2025-05-01 チールー ファーマシューティカル カンパニー、リミテッド 医薬組成物、その製造方法及び使用
TW202319050A (zh) * 2021-11-05 2023-05-16 大陸商南京明德新藥研發有限公司 氮雜螺環化合物
WO2023138576A1 (zh) * 2022-01-18 2023-07-27 齐鲁制药有限公司 螺环芳基磷氧化物与抗egfr抗体的药物组合
WO2023138574A1 (zh) * 2022-01-18 2023-07-27 齐鲁制药有限公司 螺环芳基磷氧化物与抗vegf抗体的药物组合
CN118891264A (zh) * 2022-08-01 2024-11-01 齐鲁制药有限公司 螺环胺类芳基磷氧化合物的晶型及其制备方法
WO2025202955A1 (en) 2024-03-28 2025-10-02 Pi Industries Ltd. Fused bicyclic compounds and their use as pest control agents

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Publication number Publication date
EP3165530A4 (en) 2017-07-26
WO2016000581A1 (zh) 2016-01-07
EP3165530A1 (en) 2017-05-10
PL3165530T3 (pl) 2019-07-31
US10053477B2 (en) 2018-08-21
EP3165530B1 (en) 2018-12-05
ES2714576T3 (es) 2019-05-29
US20170129909A1 (en) 2017-05-11
TW201604202A (zh) 2016-02-01
TWI571471B (zh) 2017-02-21
JP2017521436A (ja) 2017-08-03

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