TWI571471B - 螺環芳基磷氧化物和芳基磷硫化物 - Google Patents

螺環芳基磷氧化物和芳基磷硫化物 Download PDF

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Publication number
TWI571471B
TWI571471B TW104121403A TW104121403A TWI571471B TW I571471 B TWI571471 B TW I571471B TW 104121403 A TW104121403 A TW 104121403A TW 104121403 A TW104121403 A TW 104121403A TW I571471 B TWI571471 B TW I571471B
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Taiwan
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compound
amino
title compound
shown below
mmol
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TW104121403A
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Chinese (zh)
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TW201604202A (zh
Inventor
丁照中
張明會
陳曙輝
劉希樂
朱屹東
范傳文
趙保平
張龍
楊瑩瑩
鄭慶梅
鄭善松
萬海文
胡金清
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齊魯製藥有限公司
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Priority claimed from CN201410317076.7A external-priority patent/CN105330698B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65615—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing a spiro condensed ring system of the formula where at least one of the atoms X or Y is a hetero atom, e.g. S

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
TW104121403A 2014-07-04 2015-07-01 螺環芳基磷氧化物和芳基磷硫化物 TWI571471B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410317076.7A CN105330698B (zh) 2014-07-04 2014-07-04 螺环芳基磷氧化物和硫化物
CN201510350019 2015-06-23

Publications (2)

Publication Number Publication Date
TW201604202A TW201604202A (zh) 2016-02-01
TWI571471B true TWI571471B (zh) 2017-02-21

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TW104121403A TWI571471B (zh) 2014-07-04 2015-07-01 螺環芳基磷氧化物和芳基磷硫化物

Country Status (7)

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US (1) US10053477B2 (enExample)
EP (1) EP3165530B1 (enExample)
JP (1) JP6487527B2 (enExample)
ES (1) ES2714576T3 (enExample)
PL (1) PL3165530T3 (enExample)
TW (1) TWI571471B (enExample)
WO (1) WO2016000581A1 (enExample)

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JP6487527B2 (ja) 2014-07-04 2019-03-20 チル ファーマシューティカル カンパニー リミテッド スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ）
JP6717457B2 (ja) 2017-01-23 2020-07-01 シージャーズォアン サガシティ ニュー ドラッグ デベロップメント カンパニー リミテッド Ｗｅｅ１阻害剤としての１，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン誘導体
CN110944999A (zh) * 2017-08-01 2020-03-31 勃林格殷格翰国际有限公司 中间体化合物和方法
US20210009613A1 (en) * 2017-12-12 2021-01-14 Shenzhen Targetrx, Inc. Arylphosphine oxides for inhibiting kinase activity
EP3715343B1 (en) * 2017-12-21 2024-02-14 Shenzhen TargetRx, Inc. Diphenylaminopyrimidine compound for inhibiting kinase activity
WO2019201334A1 (zh) * 2018-04-20 2019-10-24 南京明德新药研发有限公司 二甲基氧膦类化合物
WO2020147702A1 (en) * 2019-01-17 2020-07-23 Betta Pharmaceuticals Co., Ltd Egfr inhibitors, compositions and methods thereof
UY38988A (es) 2019-12-19 2021-06-30 Janssen Pharmaceutica Nv Derivados espiráncos sustituidos de cadena lineal
JP7671362B2 (ja) * 2021-07-05 2025-05-01 チールー ファーマシューティカル カンパニー、リミテッド 医薬組成物、その製造方法及び使用
WO2023078411A1 (zh) * 2021-11-05 2023-05-11 南京明德新药研发有限公司 氮杂螺环化合物
WO2023138574A1 (zh) * 2022-01-18 2023-07-27 齐鲁制药有限公司 螺环芳基磷氧化物与抗vegf抗体的药物组合
WO2023138576A1 (zh) * 2022-01-18 2023-07-27 齐鲁制药有限公司 螺环芳基磷氧化物与抗egfr抗体的药物组合
CN118891264A (zh) * 2022-08-01 2024-11-01 齐鲁制药有限公司 螺环胺类芳基磷氧化合物的晶型及其制备方法
UY41082A (es) 2024-03-28 2025-08-29 Pi Industries Ltd Compuestos bicíclicos condensados y su uso como agentes de control de plagas

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CN103153064A (zh) * 2010-10-14 2013-06-12 阿里亚德医药股份有限公司 抑制egfr导致的癌症中细胞增殖的方法

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US9273077B2 (en) * 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
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JP2015529665A (ja) 2012-08-27 2015-10-08 ツェーエムエム−フォルシュングスツェントルム フュア モレクラレ メディツィン ゲーエムベーハー Ｍｔｈ１阻害剤としてのアミノヘテロアリール化合物
JP6487527B2 (ja) 2014-07-04 2019-03-20 チル ファーマシューティカル カンパニー リミテッド スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ）

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CN103153064A (zh) * 2010-10-14 2013-06-12 阿里亚德医药股份有限公司 抑制egfr导致的癌症中细胞增殖的方法

Also Published As

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WO2016000581A1 (zh) 2016-01-07
EP3165530B1 (en) 2018-12-05
ES2714576T3 (es) 2019-05-29
US10053477B2 (en) 2018-08-21
US20170129909A1 (en) 2017-05-11
PL3165530T3 (pl) 2019-07-31
EP3165530A4 (en) 2017-07-26
JP6487527B2 (ja) 2019-03-20
EP3165530A1 (en) 2017-05-10
TW201604202A (zh) 2016-02-01
JP2017521436A (ja) 2017-08-03

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