ES2712803T3 - Inhibidores de histona desacetilasa - Google Patents
Inhibidores de histona desacetilasa Download PDFInfo
- Publication number
- ES2712803T3 ES2712803T3 ES12751918T ES12751918T ES2712803T3 ES 2712803 T3 ES2712803 T3 ES 2712803T3 ES 12751918 T ES12751918 T ES 12751918T ES 12751918 T ES12751918 T ES 12751918T ES 2712803 T3 ES2712803 T3 ES 2712803T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- alkyl
- mmol
- salt
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 ***C(*)=C(*)C(Nc(cc(*)c(*)c1)c1N)=O Chemical compound ***C(*)=C(*)C(Nc(cc(*)c(*)c1)c1N)=O 0.000 description 1
- RUROFEVDCUGKHD-QPJJXVBHSA-N BrC/C=C/c1ccccc1 Chemical compound BrC/C=C/c1ccccc1 RUROFEVDCUGKHD-QPJJXVBHSA-N 0.000 description 1
- NCRMDLICWRYCAF-LWVORGKXSA-N CC(C)(C)OC(Nc1ccccc1NC(/C=C/c1c(C)[n](C/C=C/c2ccccc2)nc1C)=O)=O Chemical compound CC(C)(C)OC(Nc1ccccc1NC(/C=C/c1c(C)[n](C/C=C/c2ccccc2)nc1C)=O)=O NCRMDLICWRYCAF-LWVORGKXSA-N 0.000 description 1
- WNZNBJIZTLJYRD-UHFFFAOYSA-N CC(C)C(C=C1N)=CCC1NC(OC(C)(C)C)=O Chemical compound CC(C)C(C=C1N)=CCC1NC(OC(C)(C)C)=O WNZNBJIZTLJYRD-UHFFFAOYSA-N 0.000 description 1
- JAGPJBBEHGCFGM-AATRIKPKSA-N CC([n]1nc(C)c(/C=C/C(OC)=O)c1C)=O Chemical compound CC([n]1nc(C)c(/C=C/C(OC)=O)c1C)=O JAGPJBBEHGCFGM-AATRIKPKSA-N 0.000 description 1
- CGFUBILWMLNFTH-UHFFFAOYSA-N CC([n]1nc(C)c(I)c1C)=O Chemical compound CC([n]1nc(C)c(I)c1C)=O CGFUBILWMLNFTH-UHFFFAOYSA-N 0.000 description 1
- MZZXIXHKDJNBJQ-UHFFFAOYSA-N Cc([nH]nc1C)c1I Chemical compound Cc([nH]nc1C)c1I MZZXIXHKDJNBJQ-UHFFFAOYSA-N 0.000 description 1
- YGTLTZBEMQRWJF-IIXCLMFLSA-N Cc1c(/C=C/C(Nc(cccc2)c2N)=O)c(C)n[n]1C/C=C/c1ccccc1 Chemical compound Cc1c(/C=C/C(Nc(cccc2)c2N)=O)c(C)n[n]1C/C=C/c1ccccc1 YGTLTZBEMQRWJF-IIXCLMFLSA-N 0.000 description 1
- VEOALGLUCHGGQJ-GOKBKIRCSA-N Cc1c(/C=C/C(O)=O)c(C)n[n]1C/C=C/c1ccccc1 Chemical compound Cc1c(/C=C/C(O)=O)c(C)n[n]1C/C=C/c1ccccc1 VEOALGLUCHGGQJ-GOKBKIRCSA-N 0.000 description 1
- SAQXWQPSPKAOAU-SNAWJCMRSA-N Cc1c(/C=C/C(OC)=O)c(C)n[nH]1 Chemical compound Cc1c(/C=C/C(OC)=O)c(C)n[nH]1 SAQXWQPSPKAOAU-SNAWJCMRSA-N 0.000 description 1
- ZOXDZEOCTJXBRM-VAWYXSNFSA-N Cc1c(/C=C/C(OC)=O)c(C)n[n]1CCCc1ccccc1 Chemical compound Cc1c(/C=C/C(OC)=O)c(C)n[n]1CCCc1ccccc1 ZOXDZEOCTJXBRM-VAWYXSNFSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161447416P | 2011-02-28 | 2011-02-28 | |
| PCT/US2012/026874 WO2012118782A1 (en) | 2011-02-28 | 2012-02-28 | Histone deacetylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2712803T3 true ES2712803T3 (es) | 2019-05-14 |
Family
ID=46758274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12751918T Active ES2712803T3 (es) | 2011-02-28 | 2012-02-28 | Inhibidores de histona desacetilasa |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9540395B2 (enExample) |
| EP (2) | EP3524324A1 (enExample) |
| JP (3) | JP6250403B2 (enExample) |
| AU (2) | AU2012223509B2 (enExample) |
| CA (2) | CA2828524C (enExample) |
| DK (1) | DK2680694T3 (enExample) |
| ES (1) | ES2712803T3 (enExample) |
| PT (1) | PT2680694T (enExample) |
| WO (1) | WO2012118782A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2620027T3 (es) | 2008-09-03 | 2017-06-27 | Biomarin Pharmaceutical Inc. | Composiciones que incluyen derivados del ácido 6-aminohexanoico como inhibidores de HDAC |
| US8957066B2 (en) * | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US9540395B2 (en) * | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| JP6240063B2 (ja) | 2011-04-28 | 2017-11-29 | ザ ブロード インスティテュート， インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| CA2880117C (en) | 2012-07-27 | 2021-04-06 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| KR20150132345A (ko) * | 2013-03-15 | 2015-11-25 | 바이오마린 파머수티컬 인크. | Hdac 저해제 |
| WO2015058106A1 (en) * | 2013-10-18 | 2015-04-23 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
| WO2016109549A1 (en) | 2014-12-30 | 2016-07-07 | University Of Utah Research Foundation | Hdac1,2 inhibitors and methods of using the same |
| WO2017039726A1 (en) | 2015-08-28 | 2017-03-09 | Uwm Research Foundation, Inc. | Novel hdac inhibitors and methods of treatment using the same |
| CN105920604B (zh) * | 2016-06-08 | 2019-09-03 | 上海荻硕贝肯生物科技有限公司 | 用于治疗白血病的联合用药物及其在治疗白血病中的应用 |
| CN106977474B (zh) * | 2017-05-10 | 2020-04-07 | 四川大学 | 一种取代2-氰基-3-苯基呋喃-丙烯酰胺衍生物及其制备方法和用途 |
| EP3737362B1 (en) * | 2018-01-12 | 2025-10-15 | Kdac Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| GB201901559D0 (en) | 2019-02-05 | 2019-03-27 | Syngenta Crop Protection Ag | Herbicidal compositions |
| US11453661B2 (en) | 2019-09-27 | 2022-09-27 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN110981868B (zh) * | 2019-11-05 | 2021-08-31 | 中山大学 | 咪唑并吡啶类化合物、包含该化合物的药物组合物及其制备方法和用途 |
| CN113248499A (zh) * | 2021-06-07 | 2021-08-13 | 中国科学院广州生物医药与健康研究院 | 一种吲嗪类化合物的制备及应用 |
| WO2023034440A1 (en) | 2021-09-01 | 2023-03-09 | Case Western Reserve University | Treatment of neurodegenerative diseases with hdac inhibitors |
Family Cites Families (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855442A (en) | 1988-04-13 | 1989-08-08 | Monsanto Company | Substituted 3-hydroxy pyrazoles |
| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US6794392B1 (en) | 1996-09-30 | 2004-09-21 | Schering Aktiengesellschaft | Cell differentiation inducer |
| JPH11269140A (ja) | 1998-03-23 | 1999-10-05 | Mitsui Chem Inc | 分化誘導剤 |
| JPH11269146A (ja) | 1998-03-24 | 1999-10-05 | Mitsui Chem Inc | 分化誘導剤 |
| JP4405602B2 (ja) | 1998-04-16 | 2010-01-27 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | ヒストン脱アセチル化酵素阻害剤 |
| WO2000035877A1 (en) | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
| JP2000256194A (ja) | 1999-01-06 | 2000-09-19 | Mitsui Chemicals Inc | 核内レセプタ作動薬およびその効果増強剤 |
| AU3676000A (en) | 1999-04-09 | 2000-11-14 | Mochida Pharmaceutical Co., Ltd. | 4-hydroxypiperidine derivatives having antiarrhythmic effect |
| US6541661B1 (en) * | 1999-11-23 | 2003-04-01 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| WO2002018335A1 (en) | 2000-08-28 | 2002-03-07 | Yamanouchi Pharmaceutical Co., Ltd. | Cyclic amine derivatives |
| US20040142859A1 (en) | 2002-05-02 | 2004-07-22 | Steffan Joan S. | Method for treating neurodegenerative, psychiatric, and other disorders with deacetylase inhibitors |
| WO2002090534A1 (en) | 2001-05-02 | 2002-11-14 | The Regents Of The University Of California | Method for treating neurodegenerative, psychiatric and other disorders with deacetylase inhibitors |
| US6784173B2 (en) | 2001-06-15 | 2004-08-31 | Hoffmann-La Roche Inc. | Aromatic dicarboxylic acid derivatives |
| AR034897A1 (es) * | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
| US6806272B2 (en) | 2001-09-04 | 2004-10-19 | Boehringer Ingelheim Pharma Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| CA2465978C (en) * | 2001-09-14 | 2015-04-07 | Soon Hyung Woo | Inhibitors of histone deacetylase |
| JP2003137866A (ja) | 2001-11-01 | 2003-05-14 | Sankyo Co Ltd | フェニレンジアミン誘導体 |
| EA006707B1 (ru) | 2002-03-13 | 2006-02-24 | Янссен Фармацевтика Н. В. | Сульфонилпроизводные в качестве новых ингибиторов гистон-деацетилазы |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| US20040072770A1 (en) | 2002-07-03 | 2004-04-15 | Besterman Jeffrey M. | Methods for specifically inhibiting histone deacetylase-7 and 8 |
| JP2004035485A (ja) | 2002-07-04 | 2004-02-05 | Mitsui Chemicals Inc | テロメラーゼ阻害剤 |
| US20050215601A1 (en) | 2002-09-25 | 2005-09-29 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for rheumatic disease comprising benzamide derivative as active ingredient |
| KR20050074487A (ko) | 2002-10-17 | 2005-07-18 | 메틸진, 인크. | 히스톤 데아세틸라아제의 억제제 |
| WO2004039318A2 (en) | 2002-10-25 | 2004-05-13 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
| US6852748B1 (en) | 2002-10-30 | 2005-02-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide |
| TW200426138A (en) | 2002-12-10 | 2004-12-01 | Hoffmann La Roche | Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents |
| WO2004058234A2 (en) | 2002-12-27 | 2004-07-15 | Schering Aktiengesellschaft | Pharmaceutical combinations of phthalazine vegf inhibitors and benzamide hdac inhibitors |
| US7208491B2 (en) | 2003-02-07 | 2007-04-24 | Hoffmann-La Roche Inc. | N-monoacylated o-phenylenediamines |
| EP1603905A1 (en) | 2003-02-10 | 2005-12-14 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| US7030112B2 (en) | 2003-03-25 | 2006-04-18 | Bristol-Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
| TW200424187A (en) | 2003-04-04 | 2004-11-16 | Hoffmann La Roche | New oxime derivatives and their use as pharmaceutically active agents |
| GB0315203D0 (en) | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
| TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| ZA200510137B (en) | 2003-07-24 | 2007-04-25 | Leo Pharma As | Novel aminobenzophenone compounds |
| WO2005030705A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7141596B2 (en) | 2003-10-08 | 2006-11-28 | Incyte Corporation | Inhibitors of proteins that bind phosphorylated molecules |
| EP1696898B1 (en) | 2003-12-02 | 2015-11-18 | The Ohio State University Research Foundation | Zn 2+ -chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors |
| EP1541549A1 (en) | 2003-12-12 | 2005-06-15 | Exonhit Therapeutics S.A. | Tricyclic hydroxamate and benzaminde derivatives, compositions and methods |
| EP2272827A1 (en) | 2004-03-11 | 2011-01-12 | 4Sc Ag | Sulphonylpyrroles as hdac inhibitors |
| PL2156824T3 (pl) | 2004-03-25 | 2013-03-29 | Astellas Pharma Inc | Kompozycja solifenacyny lub jej soli do zastosowania w formulacji stałej |
| WO2005092899A1 (en) | 2004-03-26 | 2005-10-06 | Methylgene Inc. | Inhibitors of histone deacetylase |
| CA2567851A1 (en) | 2004-05-21 | 2006-01-05 | Merck & Co., Inc. | Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity |
| US20080234254A1 (en) | 2004-06-10 | 2008-09-25 | University Of Leeds | Inhibitors of Histone Deacetylase |
| AU2005261501A1 (en) | 2004-07-12 | 2006-01-19 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Amide derivatives as inhibitors of histone deacetylase |
| JP2008507528A (ja) | 2004-07-22 | 2008-03-13 | メルク エンド カムパニー インコーポレーテッド | 置換ピラゾール、このような化合物を含有する組成物及び使用方法 |
| US8710038B2 (en) | 2004-09-17 | 2014-04-29 | Exelixis, Inc. | Pyrazole kinase modulators and methods of use |
| JP2008516976A (ja) | 2004-10-15 | 2008-05-22 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 抗増殖活性を有するインダンアミド |
| CN100349070C (zh) | 2004-11-25 | 2007-11-14 | 同济大学 | 一种偶氮/酞菁复合单层有机光电导体及其制备方法 |
| EP1828186A1 (en) | 2004-12-13 | 2007-09-05 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
| EP1824831A2 (en) | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20080312223A1 (en) | 2004-12-30 | 2008-12-18 | Astex Therapeutics Limited | Thiazole And Isothiazole Derivatives That Modulate The Activity Of CDK, GSK And Aurora Kinases |
| EA015533B1 (ru) | 2005-03-15 | 2011-08-30 | 4Сц Аг | N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы |
| US20060223807A1 (en) | 2005-03-29 | 2006-10-05 | University Of Massachusetts Medical School, A Massachusetts Corporation | Therapeutic methods for type I diabetes |
| AU2006228957A1 (en) | 2005-04-01 | 2006-10-05 | Methylgene Inc. | Inhibitors of histone deacetylase |
| JP5054671B2 (ja) * | 2005-04-07 | 2012-10-24 | フォーエスシー アクチエンゲゼルシャフト | ヒストンデアセチラーゼインヒビターとしてのスルホニルピロール |
| AU2006240258A1 (en) * | 2005-04-20 | 2006-11-02 | Merck Sharp & Dohme Corp. | Benzothiophene derivatives |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| JP4528918B2 (ja) | 2005-06-21 | 2010-08-25 | 学校法人 関西大学 | カルボキサミド誘導体 |
| US8158825B2 (en) | 2005-06-24 | 2012-04-17 | Merck Sharp & Dohme Corp. | Modified malonate derivatives |
| CN101263121A (zh) | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | 组蛋白脱乙酰基酶抑制剂 |
| KR20080052611A (ko) | 2005-08-26 | 2008-06-11 | 메틸진 인크. | 히스톤 탈아세틸 효소의 벤조디아제핀 및 벤조피페라진유도체 억제제 |
| WO2007027855A2 (en) | 2005-09-01 | 2007-03-08 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| CN101287706A (zh) | 2005-09-21 | 2008-10-15 | 尼科梅德有限责任公司 | 作为组蛋白脱乙酰基酶抑制剂的磺酰基吡咯盐酸盐 |
| EP1928872B1 (en) | 2005-09-21 | 2012-03-14 | 4Sc Ag | Novel sulphonylpyrroles as inhibitors of hdac |
| WO2007044565A2 (en) | 2005-10-06 | 2007-04-19 | University Of Massachusetts | Composition and synthesis of new reagents for inhibition of hiv replication |
| GB0521244D0 (en) | 2005-10-19 | 2005-11-30 | Astrazeneca Ab | Benzamide compounds |
| AU2006312084A1 (en) | 2005-11-03 | 2007-05-18 | Merck Sharp & Dohme Corp. | Substituted nicotinamide compounds |
| WO2007058927A1 (en) | 2005-11-11 | 2007-05-24 | The Scripps Research Institute | Histone deacetylase inhibitors as therapeutics for neurological diseases |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| WO2007087129A2 (en) | 2006-01-12 | 2007-08-02 | Merck & Co., Inc. | Fluorinated arylamide derivatives |
| EP1973405A4 (en) | 2006-01-12 | 2011-06-01 | Merck Sharp & Dohme | HYDROXYALKYLARYLAMID DERIVATIVES |
| EP1976835A2 (en) | 2006-01-13 | 2008-10-08 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CA2631874C (en) | 2006-01-19 | 2014-11-18 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| WO2007082882A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| JP5225104B2 (ja) | 2006-01-19 | 2013-07-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体 |
| JP5225103B2 (ja) | 2006-01-19 | 2013-07-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストン・デアセチラーゼの新規なインヒビターとしてのヘテロシクリルアルキル誘導体 |
| US8114876B2 (en) | 2006-01-19 | 2012-02-14 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| AU2007221207A1 (en) * | 2006-02-28 | 2007-09-07 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
| GB0606876D0 (en) | 2006-04-05 | 2006-05-17 | Glaxo Group Ltd | Compounds |
| JP5554988B2 (ja) * | 2006-04-07 | 2014-07-23 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| US8119652B2 (en) | 2006-05-18 | 2012-02-21 | Merck Sharp & Dohme Corp. | Aryl-fused spirocyclic compounds |
| GB0614070D0 (en) | 2006-07-14 | 2006-08-23 | Glaxo Group Ltd | Compounds |
| US7981874B2 (en) | 2006-07-20 | 2011-07-19 | Merck Sharp & Dohme Corp. | Phosphorus derivatives as histone deacetylase inhibitors |
| US8653278B2 (en) | 2006-08-03 | 2014-02-18 | Georgetown University | Isoform selective HDAC inhibitors |
| JP2010502741A (ja) | 2006-09-11 | 2010-01-28 | キュリス，インコーポレイテッド | Ｐｔｋインヒビターとしての亜鉛結合部分を含む置換２−インドリノン |
| SG174772A1 (en) | 2006-09-11 | 2011-10-28 | Curis Inc | Multi-functional small molecules as anti-proliferative agents |
| EP1973872A4 (en) | 2006-12-19 | 2012-05-09 | Methylgene Inc | HISTONDEACETYLASE HEMMER AND PROPHARMAKA THEREOF |
| ATE528285T1 (de) * | 2006-12-26 | 2011-10-15 | Santen Pharmaceutical Co Ltd | Neue n-(2-aminophenyl)benzamidderivate mit harnstoffstruktur |
| WO2008084218A1 (en) | 2007-01-12 | 2008-07-17 | Boehringer Ingelheim International Gmbh | Benzazole derivatives for the treatment of inflammations |
| TW200911757A (en) | 2007-01-18 | 2009-03-16 | Takeda San Diego Inc | Crystalline forms of histone deacetylase inhibitors |
| US8030344B2 (en) | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
| BRPI0808772A2 (pt) | 2007-03-14 | 2014-08-12 | Exelixis Inc | Inibidores da via de hedgehog |
| CN103087043A (zh) | 2007-03-16 | 2013-05-08 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂 |
| CA2680517A1 (en) | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | Novel pyridinecarboxylic acid (2-aminophenyl)amide derivative having urea structure |
| WO2008123395A1 (ja) | 2007-03-28 | 2008-10-16 | Santen Pharmaceutical Co., Ltd. | ヒストン脱アセチル化酵素阻害作用を有する化合物を有効成分として含有する眼圧下降剤 |
| KR101561292B1 (ko) | 2007-04-09 | 2015-10-19 | 메틸진 인코포레이티드 | 히스톤 탈아세틸화효소의 억제제 |
| JP2010531875A (ja) | 2007-06-26 | 2010-09-30 | ギリード・サイエンシズ・インコーポレーテッド | イミダゾピリジニルチアゾリルヒストンデアセチラーゼ阻害剤 |
| AU2008269154B2 (en) | 2007-06-27 | 2014-06-12 | Merck Sharp & Dohme Llc | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| ME00962B (me) | 2007-06-29 | 2012-06-20 | Pfizer | Benzimidazolski derivati |
| WO2009015237A1 (en) | 2007-07-23 | 2009-01-29 | Syndax Pharmaceuticals, Inc. | Novel compounds and methods of using them |
| AU2008284304A1 (en) | 2007-08-09 | 2009-02-12 | Merck & Co., Inc. | Silicon derivatives as histone deacetylase inhibitors |
| WO2009024825A1 (en) | 2007-08-21 | 2009-02-26 | Astrazeneca Ab | 2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors |
| EP2203171A2 (en) | 2007-08-21 | 2010-07-07 | Merck Sharp & Dohme Corp. | Cb2 receptor ligands for the treatment of pain |
| TW200918521A (en) | 2007-08-31 | 2009-05-01 | Astrazeneca Ab | Heterocyclic amides and methods of use thereof |
| WO2009036057A1 (en) | 2007-09-10 | 2009-03-19 | Curis, Inc. | Antiproliferative agents containing a zinc binding moiety |
| CN101861151B (zh) | 2007-09-14 | 2014-08-13 | 梅特希尔基因公司 | 使用组蛋白脱乙酰基酶hdac1、hdac2和/或hdac3的选择性抑制剂和微管稳定剂的癌症组合治疗 |
| AU2008300827B2 (en) | 2007-09-19 | 2013-04-04 | 4Sc Ag | Novel tetrahydrofusedpyridines as histone deacetylase inhibitors |
| AU2008307541B2 (en) | 2007-10-01 | 2015-02-12 | Lixte Biotechnology, Inc. | HDAC inhibitors |
| JP2011500783A (ja) | 2007-10-22 | 2011-01-06 | オーキッド リサーチ ラボラトリーズ リミテッド | ヒストンデアセチラーゼ阻害剤 |
| EP2060565A1 (en) | 2007-11-16 | 2009-05-20 | 4Sc Ag | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases |
| US20100292320A1 (en) | 2007-12-14 | 2010-11-18 | Gilead Colorado, Inc. | Benzofuran anilide histone deacetylase inhibitors |
| WO2009086012A1 (en) | 2007-12-20 | 2009-07-09 | Curis, Inc. | Aurora inhibitors containing a zinc binding moiety |
| EP2100882A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts |
| SG192439A1 (en) | 2008-06-27 | 2013-08-30 | Novartis Ag | Organic compounds |
| WO2010009139A2 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Imidazolyl pyrimidine inhibitor compounds |
| WO2010009155A2 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Fused heterocyclyc inhibitor compounds |
| EP2303841A1 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| MX2011001090A (es) | 2008-07-28 | 2011-03-15 | Gilead Sciences Inc | Compuestos de inhibidor de desacetilasa de histona de cicloalquilideno y heterocicloalquilideno. |
| ES2620027T3 (es) | 2008-09-03 | 2017-06-27 | Biomarin Pharmaceutical Inc. | Composiciones que incluyen derivados del ácido 6-aminohexanoico como inhibidores de HDAC |
| TW201014856A (en) | 2008-09-05 | 2010-04-16 | Elan Pharm Inc | N-sulfonamido polycyclic pyrazolyl compounds |
| US8202866B2 (en) | 2008-09-17 | 2012-06-19 | Hoffmann-La Roche Inc. | Ortho-aminoanilides for the treatment of cancer |
| TW201016676A (en) | 2008-10-03 | 2010-05-01 | Astrazeneca Ab | Heterocyclic derivatives and methods of use thereof |
| US20110212943A1 (en) | 2008-10-15 | 2011-09-01 | Orchid Research Laboratories Limited | Novel bridged cyclic compounds as histone deacetylase inhibitors |
| PL2349245T3 (pl) | 2008-10-29 | 2017-07-31 | Istituto Superiore di Sanità | Leczenie utajonego zakażenia wirusem hiv-1 za pomocą auranofiny lub tritlenku diarsenu |
| KR20110117194A (ko) | 2009-02-23 | 2011-10-26 | 에프. 호프만-라 로슈 아게 | 암 치료를 위한 신규한 오르토-아미노아미드 |
| KR101145345B1 (ko) | 2009-04-24 | 2012-07-09 | 계명대학교 산학협력단 | 세포증식 억제제로서 유용한 2-싸이오-4-아미노 피리미딘 유도체 및 그 제조방법 |
| JP5807971B2 (ja) | 2009-04-27 | 2015-11-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｘｃｒ３受容体アンタゴニスト |
| US8362249B2 (en) | 2009-04-27 | 2013-01-29 | Boehringer Ingelheim International Gmbh | CXCR3 receptor antagonists |
| WO2010127152A2 (en) | 2009-04-29 | 2010-11-04 | Irm Llc | Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors |
| JP5713999B2 (ja) | 2009-05-15 | 2015-05-07 | コリア リサーチ インスティテュート オブ ケミカル テクノロジー | アミド化合物、その製造方法及びそれを含む薬学組成物 |
| US8211901B2 (en) | 2009-05-22 | 2012-07-03 | Shenzhen Chipscreen Biosciences Ltd. | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
| EP2440519A1 (en) | 2009-06-08 | 2012-04-18 | Gilead Sciences, Inc. | Alkanoylamino benzamide aniline hdac inihibitor compounds |
| AU2010259042A1 (en) | 2009-06-08 | 2011-12-15 | Gilead Sciences, Inc. | Cycloalkylcarbamate benzamide aniline HDAC inhibitor compounds |
| CN101648922B (zh) | 2009-08-20 | 2011-08-31 | 苏州东南药物研发有限责任公司 | 苯甲酰胺类组蛋白去乙酰酶抑制剂及其用途 |
| WO2012016081A2 (en) * | 2010-07-30 | 2012-02-02 | The Regents Of The University Of California | Method and therapeutic for the treatment and regulation of memory formation |
| US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) * | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
-
2012
- 2012-02-28 US US13/823,708 patent/US9540395B2/en not_active Expired - Fee Related
- 2012-02-28 ES ES12751918T patent/ES2712803T3/es active Active
- 2012-02-28 CA CA2828524A patent/CA2828524C/en not_active Expired - Fee Related
- 2012-02-28 PT PT12751918T patent/PT2680694T/pt unknown
- 2012-02-28 EP EP18214838.7A patent/EP3524324A1/en not_active Withdrawn
- 2012-02-28 WO PCT/US2012/026874 patent/WO2012118782A1/en not_active Ceased
- 2012-02-28 CA CA3061239A patent/CA3061239A1/en not_active Abandoned
- 2012-02-28 AU AU2012223509A patent/AU2012223509B2/en not_active Ceased
- 2012-02-28 JP JP2013556793A patent/JP6250403B2/ja not_active Expired - Fee Related
- 2012-02-28 DK DK12751918.9T patent/DK2680694T3/en active
- 2012-02-28 EP EP12751918.9A patent/EP2680694B1/en not_active Not-in-force
-
2017
- 2017-02-08 AU AU2017200850A patent/AU2017200850B2/en not_active Ceased
- 2017-08-24 JP JP2017161679A patent/JP2018012718A/ja active Pending
-
2018
- 2018-12-26 JP JP2018242538A patent/JP2019065037A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017200850A1 (en) | 2017-02-23 |
| AU2012223509A1 (en) | 2013-09-19 |
| JP2014514261A (ja) | 2014-06-19 |
| EP2680694A4 (en) | 2014-09-03 |
| JP2018012718A (ja) | 2018-01-25 |
| CA3061239A1 (en) | 2012-09-07 |
| WO2012118782A1 (en) | 2012-09-07 |
| EP2680694B1 (en) | 2019-01-02 |
| JP6250403B2 (ja) | 2017-12-20 |
| US20140051680A1 (en) | 2014-02-20 |
| EP2680694A1 (en) | 2014-01-08 |
| EP3524324A1 (en) | 2019-08-14 |
| JP2019065037A (ja) | 2019-04-25 |
| AU2017200850B2 (en) | 2018-09-06 |
| PT2680694T (pt) | 2019-03-14 |
| AU2012223509B2 (en) | 2016-11-10 |
| CA2828524C (en) | 2020-01-07 |
| CA2828524A1 (en) | 2012-09-07 |
| DK2680694T3 (en) | 2019-03-25 |
| US9540395B2 (en) | 2017-01-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2712803T3 (es) | Inhibidores de histona desacetilasa | |
| ES2780693T3 (es) | Inhibidores de la histona deacetilasa | |
| ES2680224T3 (es) | Inhibidores de HDAC | |
| US10981933B2 (en) | Histone deacetylase inhibitors | |
| HK40010651A (en) | Histone deacetylase inhibitors | |
| HK1193944B (en) | Histone deacetylase inhibitors | |
| HK1193944A (en) | Histone deacetylase inhibitors | |
| NZ711592B2 (en) | Histone deacetylase inhibitors | |
| HK1218067B (en) | Histone deacetylase inhibitors |