ES2712803T3 - Inhibidores de histona desacetilasa - Google Patents
Inhibidores de histona desacetilasa Download PDFInfo
- Publication number
- ES2712803T3 ES2712803T3 ES12751918T ES12751918T ES2712803T3 ES 2712803 T3 ES2712803 T3 ES 2712803T3 ES 12751918 T ES12751918 T ES 12751918T ES 12751918 T ES12751918 T ES 12751918T ES 2712803 T3 ES2712803 T3 ES 2712803T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- alkyl
- mmol
- salt
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 ***C(*)=C(*)C(Nc(cc(*)c(*)c1)c1N)=O Chemical compound ***C(*)=C(*)C(Nc(cc(*)c(*)c1)c1N)=O 0.000 description 1
- RUROFEVDCUGKHD-QPJJXVBHSA-N BrC/C=C/c1ccccc1 Chemical compound BrC/C=C/c1ccccc1 RUROFEVDCUGKHD-QPJJXVBHSA-N 0.000 description 1
- NCRMDLICWRYCAF-LWVORGKXSA-N CC(C)(C)OC(Nc1ccccc1NC(/C=C/c1c(C)[n](C/C=C/c2ccccc2)nc1C)=O)=O Chemical compound CC(C)(C)OC(Nc1ccccc1NC(/C=C/c1c(C)[n](C/C=C/c2ccccc2)nc1C)=O)=O NCRMDLICWRYCAF-LWVORGKXSA-N 0.000 description 1
- WNZNBJIZTLJYRD-UHFFFAOYSA-N CC(C)C(C=C1N)=CCC1NC(OC(C)(C)C)=O Chemical compound CC(C)C(C=C1N)=CCC1NC(OC(C)(C)C)=O WNZNBJIZTLJYRD-UHFFFAOYSA-N 0.000 description 1
- JAGPJBBEHGCFGM-AATRIKPKSA-N CC([n]1nc(C)c(/C=C/C(OC)=O)c1C)=O Chemical compound CC([n]1nc(C)c(/C=C/C(OC)=O)c1C)=O JAGPJBBEHGCFGM-AATRIKPKSA-N 0.000 description 1
- CGFUBILWMLNFTH-UHFFFAOYSA-N CC([n]1nc(C)c(I)c1C)=O Chemical compound CC([n]1nc(C)c(I)c1C)=O CGFUBILWMLNFTH-UHFFFAOYSA-N 0.000 description 1
- MZZXIXHKDJNBJQ-UHFFFAOYSA-N Cc([nH]nc1C)c1I Chemical compound Cc([nH]nc1C)c1I MZZXIXHKDJNBJQ-UHFFFAOYSA-N 0.000 description 1
- YGTLTZBEMQRWJF-IIXCLMFLSA-N Cc1c(/C=C/C(Nc(cccc2)c2N)=O)c(C)n[n]1C/C=C/c1ccccc1 Chemical compound Cc1c(/C=C/C(Nc(cccc2)c2N)=O)c(C)n[n]1C/C=C/c1ccccc1 YGTLTZBEMQRWJF-IIXCLMFLSA-N 0.000 description 1
- VEOALGLUCHGGQJ-GOKBKIRCSA-N Cc1c(/C=C/C(O)=O)c(C)n[n]1C/C=C/c1ccccc1 Chemical compound Cc1c(/C=C/C(O)=O)c(C)n[n]1C/C=C/c1ccccc1 VEOALGLUCHGGQJ-GOKBKIRCSA-N 0.000 description 1
- SAQXWQPSPKAOAU-SNAWJCMRSA-N Cc1c(/C=C/C(OC)=O)c(C)n[nH]1 Chemical compound Cc1c(/C=C/C(OC)=O)c(C)n[nH]1 SAQXWQPSPKAOAU-SNAWJCMRSA-N 0.000 description 1
- ZOXDZEOCTJXBRM-VAWYXSNFSA-N Cc1c(/C=C/C(OC)=O)c(C)n[n]1CCCc1ccccc1 Chemical compound Cc1c(/C=C/C(OC)=O)c(C)n[n]1CCCc1ccccc1 ZOXDZEOCTJXBRM-VAWYXSNFSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161447416P | 2011-02-28 | 2011-02-28 | |
| PCT/US2012/026874 WO2012118782A1 (en) | 2011-02-28 | 2012-02-28 | Histone deacetylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2712803T3 true ES2712803T3 (es) | 2019-05-14 |
Family
ID=46758274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12751918T Active ES2712803T3 (es) | 2011-02-28 | 2012-02-28 | Inhibidores de histona desacetilasa |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9540395B2 (OSRAM) |
| EP (2) | EP3524324A1 (OSRAM) |
| JP (3) | JP6250403B2 (OSRAM) |
| AU (2) | AU2012223509B2 (OSRAM) |
| CA (2) | CA3061239A1 (OSRAM) |
| DK (1) | DK2680694T3 (OSRAM) |
| ES (1) | ES2712803T3 (OSRAM) |
| PT (1) | PT2680694T (OSRAM) |
| WO (1) | WO2012118782A1 (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2735593C (en) | 2008-09-03 | 2017-08-15 | Repligen Corporation | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| JP6250403B2 (ja) | 2011-02-28 | 2017-12-20 | バイオマリン ファーマシューティカル インク | ヒストン脱アセチル化酵素阻害剤 |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) * | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| EP2712655B1 (en) | 2011-04-28 | 2019-12-18 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| JP6337255B2 (ja) | 2012-07-27 | 2018-06-06 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | ヒストンデアセチラーゼの阻害剤 |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| BR112015023399A8 (pt) * | 2013-03-15 | 2019-12-03 | Biomarin Pharm Inc | inibidores de hdac, seu uso e composição farmacêutica |
| WO2015058106A1 (en) * | 2013-10-18 | 2015-04-23 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
| US20180021331A1 (en) | 2014-12-30 | 2018-01-25 | University Of Utah Research Foundation | Hdac1,2 inhibitors and methods of using the same |
| US11149062B2 (en) | 2015-08-28 | 2021-10-19 | Uwm Research Foundation, Inc. | HDAC inhibitors and methods of treatment using the same |
| CN105920604B (zh) * | 2016-06-08 | 2019-09-03 | 上海荻硕贝肯生物科技有限公司 | 用于治疗白血病的联合用药物及其在治疗白血病中的应用 |
| CN106977474B (zh) * | 2017-05-10 | 2020-04-07 | 四川大学 | 一种取代2-氰基-3-苯基呋喃-丙烯酰胺衍生物及其制备方法和用途 |
| US12128018B2 (en) | 2018-01-12 | 2024-10-29 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (HDAC3) inhibitor and an immunotherapy agent for the treatment of cancer |
| GB201901559D0 (en) | 2019-02-05 | 2019-03-27 | Syngenta Crop Protection Ag | Herbicidal compositions |
| AR120040A1 (es) | 2019-09-27 | 2022-01-26 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
| CN110981868B (zh) * | 2019-11-05 | 2021-08-31 | 中山大学 | 咪唑并吡啶类化合物、包含该化合物的药物组合物及其制备方法和用途 |
| CN113248499A (zh) * | 2021-06-07 | 2021-08-13 | 中国科学院广州生物医药与健康研究院 | 一种吲嗪类化合物的制备及应用 |
| US20250000847A1 (en) | 2021-09-01 | 2025-01-02 | Case Western Reserve University | Treatment of neurodegenerative diseases with hdac inhibitors |
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| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
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| JPH11269140A (ja) | 1998-03-23 | 1999-10-05 | Mitsui Chem Inc | 分化誘導剤 |
| JPH11269146A (ja) | 1998-03-24 | 1999-10-05 | Mitsui Chem Inc | 分化誘導剤 |
| JP4405602B2 (ja) | 1998-04-16 | 2010-01-27 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | ヒストン脱アセチル化酵素阻害剤 |
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- 2012-02-28 CA CA3061239A patent/CA3061239A1/en not_active Abandoned
- 2012-02-28 WO PCT/US2012/026874 patent/WO2012118782A1/en not_active Ceased
- 2012-02-28 CA CA2828524A patent/CA2828524C/en not_active Expired - Fee Related
- 2012-02-28 EP EP18214838.7A patent/EP3524324A1/en not_active Withdrawn
- 2012-02-28 US US13/823,708 patent/US9540395B2/en not_active Expired - Fee Related
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- 2012-02-28 DK DK12751918.9T patent/DK2680694T3/en active
- 2012-02-28 PT PT12751918T patent/PT2680694T/pt unknown
- 2012-02-28 EP EP12751918.9A patent/EP2680694B1/en not_active Not-in-force
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| AU2012223509A1 (en) | 2013-09-19 |
| EP2680694A4 (en) | 2014-09-03 |
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| AU2017200850B2 (en) | 2018-09-06 |
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| AU2012223509B2 (en) | 2016-11-10 |
| PT2680694T (pt) | 2019-03-14 |
| CA3061239A1 (en) | 2012-09-07 |
| EP2680694B1 (en) | 2019-01-02 |
| JP2019065037A (ja) | 2019-04-25 |
| US9540395B2 (en) | 2017-01-10 |
| EP2680694A1 (en) | 2014-01-08 |
| JP2018012718A (ja) | 2018-01-25 |
| DK2680694T3 (en) | 2019-03-25 |
| AU2017200850A1 (en) | 2017-02-23 |
| JP2014514261A (ja) | 2014-06-19 |
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