ES2709495T3 - Modulación de la expresión del transductor de señales y activador de la transcripción 3 (stat3) - Google Patents

Modulación de la expresión del transductor de señales y activador de la transcripción 3 (stat3) Download PDF

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Publication number
ES2709495T3
ES2709495T3 ES12763390T ES12763390T ES2709495T3 ES 2709495 T3 ES2709495 T3 ES 2709495T3 ES 12763390 T ES12763390 T ES 12763390T ES 12763390 T ES12763390 T ES 12763390T ES 2709495 T3 ES2709495 T3 ES 2709495T3
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Prior art keywords
stat3
isis
cells
antisense
certain embodiments
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Spanish (es)
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Eric E Swayze
Susan M Freier
Robert A Macleod
Youngsoo Kim
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
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    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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ES12763390T 2011-04-01 2012-03-30 Modulación de la expresión del transductor de señales y activador de la transcripción 3 (stat3) Active ES2709495T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161471015P 2011-04-01 2011-04-01
US201161471045P 2011-04-01 2011-04-01
US201161471001P 2011-04-01 2011-04-01
US201161471035P 2011-04-01 2011-04-01
US201161558308P 2011-11-10 2011-11-10
US201161558316P 2011-11-10 2011-11-10
PCT/US2012/031642 WO2012135736A2 (en) 2011-04-01 2012-03-30 Modulation of signal transducer and activator of transcription 3 (stat3) expression

Publications (1)

Publication Number Publication Date
ES2709495T3 true ES2709495T3 (es) 2019-04-16

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ES12763390T Active ES2709495T3 (es) 2011-04-01 2012-03-30 Modulación de la expresión del transductor de señales y activador de la transcripción 3 (stat3)

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Country Link
US (4) US8816056B2 (enExample)
EP (2) EP2697243B1 (enExample)
JP (1) JP5943993B2 (enExample)
KR (2) KR20190092590A (enExample)
CN (2) CN103562215B (enExample)
AU (1) AU2012236206C1 (enExample)
BR (1) BR112013024768B1 (enExample)
CA (1) CA2831915C (enExample)
CL (1) CL2013002773A1 (enExample)
CO (1) CO6821885A2 (enExample)
CY (1) CY1121460T1 (enExample)
DK (1) DK2697243T3 (enExample)
DO (1) DOP2013000216A (enExample)
EA (2) EA201792185A3 (enExample)
EC (1) ECSP13012909A (enExample)
ES (1) ES2709495T3 (enExample)
GT (1) GT201300232A (enExample)
HR (1) HRP20182169T1 (enExample)
HU (1) HUE042173T2 (enExample)
IL (2) IL228569A (enExample)
LT (1) LT2697243T (enExample)
ME (1) ME03317B (enExample)
MX (1) MX340086B (enExample)
MY (1) MY163004A (enExample)
NI (1) NI201300101A (enExample)
PE (2) PE20181518A1 (enExample)
PH (1) PH12013502049A1 (enExample)
PL (1) PL2697243T3 (enExample)
PT (1) PT2697243T (enExample)
RS (1) RS58489B1 (enExample)
SG (1) SG193504A1 (enExample)
SI (1) SI2697243T1 (enExample)
SM (1) SMT201900060T1 (enExample)
WO (1) WO2012135736A2 (enExample)
ZA (1) ZA201308153B (enExample)

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