SI2697243T1 - Modulacija izražanja pretvornika signala in aktivatorja transkripcije 3 (STAT3) - Google Patents

Modulacija izražanja pretvornika signala in aktivatorja transkripcije 3 (STAT3)

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Publication number
SI2697243T1
SI2697243T1 SI201231497T SI201231497T SI2697243T1 SI 2697243 T1 SI2697243 T1 SI 2697243T1 SI 201231497 T SI201231497 T SI 201231497T SI 201231497 T SI201231497 T SI 201231497T SI 2697243 T1 SI2697243 T1 SI 2697243T1
Authority
SI
Slovenia
Prior art keywords
stat3
activator
transcription
modulation
expression
Prior art date
Application number
SI201231497T
Other languages
English (en)
Inventor
Eric E. Swayze
Susan M. Freier
Robert A. Macleod
Youngsoo Kim
Original Assignee
Ionis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals, Inc. filed Critical Ionis Pharmaceuticals, Inc.
Publication of SI2697243T1 publication Critical patent/SI2697243T1/sl

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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SI201231497T 2011-04-01 2012-03-30 Modulacija izražanja pretvornika signala in aktivatorja transkripcije 3 (STAT3) SI2697243T1 (sl)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201161471001P 2011-04-01 2011-04-01
US201161471035P 2011-04-01 2011-04-01
US201161471045P 2011-04-01 2011-04-01
US201161471015P 2011-04-01 2011-04-01
US201161558316P 2011-11-10 2011-11-10
US201161558308P 2011-11-10 2011-11-10
PCT/US2012/031642 WO2012135736A2 (en) 2011-04-01 2012-03-30 Modulation of signal transducer and activator of transcription 3 (stat3) expression
EP12763390.7A EP2697243B1 (en) 2011-04-01 2012-03-30 Modulation of signal transducer and activator of transcription 3 (stat3) expression

Publications (1)

Publication Number Publication Date
SI2697243T1 true SI2697243T1 (sl) 2019-05-31

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US (4) US8816056B2 (sl)
EP (2) EP3466960A3 (sl)
JP (1) JP5943993B2 (sl)
KR (2) KR20190092590A (sl)
CN (2) CN103562215B (sl)
AU (1) AU2012236206C1 (sl)
BR (1) BR112013024768B1 (sl)
CA (1) CA2831915C (sl)
CL (1) CL2013002773A1 (sl)
CO (1) CO6821885A2 (sl)
CY (1) CY1121460T1 (sl)
DK (1) DK2697243T3 (sl)
DO (1) DOP2013000216A (sl)
EA (2) EA201792185A3 (sl)
EC (1) ECSP13012909A (sl)
ES (1) ES2709495T3 (sl)
GT (1) GT201300232A (sl)
HR (1) HRP20182169T1 (sl)
HU (1) HUE042173T2 (sl)
IL (2) IL228569A (sl)
LT (1) LT2697243T (sl)
ME (1) ME03317B (sl)
MX (1) MX340086B (sl)
MY (1) MY163004A (sl)
NI (1) NI201300101A (sl)
PE (2) PE20181518A1 (sl)
PL (1) PL2697243T3 (sl)
PT (1) PT2697243T (sl)
RS (1) RS58489B1 (sl)
SG (1) SG193504A1 (sl)
SI (1) SI2697243T1 (sl)
WO (1) WO2012135736A2 (sl)
ZA (1) ZA201308153B (sl)

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