DOP2013000216A - Modulacion de la expresion del transductor de señales y activador de la transcripcion 3 (stat3) - Google Patents

Modulacion de la expresion del transductor de señales y activador de la transcripcion 3 (stat3)

Info

Publication number
DOP2013000216A
DOP2013000216A DO2013000216A DO2013000216A DOP2013000216A DO P2013000216 A DOP2013000216 A DO P2013000216A DO 2013000216 A DO2013000216 A DO 2013000216A DO 2013000216 A DO2013000216 A DO 2013000216A DO P2013000216 A DOP2013000216 A DO P2013000216A
Authority
DO
Dominican Republic
Prior art keywords
expression
stat3
modulation
signal transducer
transcription activator
Prior art date
Application number
DO2013000216A
Other languages
English (en)
Spanish (es)
Inventor
Eric E Swayze
Susan M Freier
Youngsoo Kim
Robert A Macleod
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of DOP2013000216A publication Critical patent/DOP2013000216A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
DO2013000216A 2011-04-01 2013-09-27 Modulacion de la expresion del transductor de señales y activador de la transcripcion 3 (stat3) DOP2013000216A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161471015P 2011-04-01 2011-04-01
US201161471045P 2011-04-01 2011-04-01
US201161471001P 2011-04-01 2011-04-01
US201161471035P 2011-04-01 2011-04-01
US201161558308P 2011-11-10 2011-11-10
US201161558316P 2011-11-10 2011-11-10

Publications (1)

Publication Number Publication Date
DOP2013000216A true DOP2013000216A (es) 2013-12-15

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DO2013000216A DOP2013000216A (es) 2011-04-01 2013-09-27 Modulacion de la expresion del transductor de señales y activador de la transcripcion 3 (stat3)

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US (4) US8816056B2 (enExample)
EP (2) EP2697243B1 (enExample)
JP (1) JP5943993B2 (enExample)
KR (2) KR20190092590A (enExample)
CN (2) CN103562215B (enExample)
AU (1) AU2012236206C1 (enExample)
BR (1) BR112013024768B1 (enExample)
CA (1) CA2831915C (enExample)
CL (1) CL2013002773A1 (enExample)
CO (1) CO6821885A2 (enExample)
CY (1) CY1121460T1 (enExample)
DK (1) DK2697243T3 (enExample)
DO (1) DOP2013000216A (enExample)
EA (2) EA201792185A3 (enExample)
EC (1) ECSP13012909A (enExample)
ES (1) ES2709495T3 (enExample)
GT (1) GT201300232A (enExample)
HR (1) HRP20182169T1 (enExample)
HU (1) HUE042173T2 (enExample)
IL (2) IL228569A (enExample)
LT (1) LT2697243T (enExample)
ME (1) ME03317B (enExample)
MX (1) MX340086B (enExample)
MY (1) MY163004A (enExample)
NI (1) NI201300101A (enExample)
PE (2) PE20181518A1 (enExample)
PH (1) PH12013502049A1 (enExample)
PL (1) PL2697243T3 (enExample)
PT (1) PT2697243T (enExample)
RS (1) RS58489B1 (enExample)
SG (1) SG193504A1 (enExample)
SI (1) SI2697243T1 (enExample)
SM (1) SMT201900060T1 (enExample)
WO (1) WO2012135736A2 (enExample)
ZA (1) ZA201308153B (enExample)

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