ES2699879T3 - Composición cosmética basada en ácido hialurónico, método de preparación y uso de la misma - Google Patents
Composición cosmética basada en ácido hialurónico, método de preparación y uso de la misma Download PDFInfo
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- ES2699879T3 ES2699879T3 ES14816108T ES14816108T ES2699879T3 ES 2699879 T3 ES2699879 T3 ES 2699879T3 ES 14816108 T ES14816108 T ES 14816108T ES 14816108 T ES14816108 T ES 14816108T ES 2699879 T3 ES2699879 T3 ES 2699879T3
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- hyaluronic acid
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- polyethylene oxide
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- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
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Landscapes
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- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Artificial Filaments (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ2013-820A CZ308492B6 (cs) | 2013-10-25 | 2013-10-25 | Kosmetická kompozice na bázi kyseliny hyaluronové, způsob její přípravy a použití |
| PCT/CZ2014/000120 WO2015058734A1 (en) | 2013-10-25 | 2014-10-24 | Cosmetic composition based on hyaluronic acid, method of preparation and use thereof |
Publications (1)
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| ES2699879T3 true ES2699879T3 (es) | 2019-02-13 |
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| ES14816108T Active ES2699879T3 (es) | 2013-10-25 | 2014-10-24 | Composición cosmética basada en ácido hialurónico, método de preparación y uso de la misma |
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| EP (1) | EP3060195B1 (https=) |
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| US9687439B1 (en) * | 2016-01-21 | 2017-06-27 | Elc Management Llc | Methods and compositions for treating aged skin |
| CN105832600A (zh) * | 2016-04-07 | 2016-08-10 | 景东旭 | 余甘子补水美白面膜贴 |
| CN105997657A (zh) * | 2016-06-21 | 2016-10-12 | 安徽诚亚生物科技有限公司 | 一种保湿美白中药组合物 |
| BR112019014732A2 (pt) * | 2017-01-23 | 2020-03-10 | Afyx Therapeutics A/S | Método para a preparação de fibras eletrofiadas com um alto teor de uma substância bioadesiva |
| RU2019125715A (ru) | 2017-01-23 | 2021-02-24 | Афикс Терапьютикс А/С | Способ изготовления двухслойного продукта на основе электроспряденных волокон |
| JP6951111B2 (ja) * | 2017-04-24 | 2021-10-20 | 第一工業製薬株式会社 | ナノファイバー及びそれを用いたフィルタ、並びにそれらの製造方法 |
| WO2018237218A1 (en) | 2017-06-23 | 2018-12-27 | The Procter & Gamble Company | COMPOSITION AND METHOD FOR ENHANCING SKIN APPEARANCE |
| CN107875090A (zh) * | 2017-11-22 | 2018-04-06 | 苏州祖原堂纳米科技有限公司 | 一种含肽修护面膜 |
| KR102566764B1 (ko) * | 2018-02-14 | 2023-08-11 | 주식회사 엘지화학 | 보습용 조성물, 마스크 팩, 화장품 및 이의 제조방법 |
| KR20210011964A (ko) | 2018-07-03 | 2021-02-02 | 더 프록터 앤드 갬블 캄파니 | 피부 병태를 치료하는 방법 |
| ES1288669Y (es) * | 2018-12-03 | 2022-06-22 | Contipro As | Kit que contiene una preparacion activa biologicamente |
| US20220354752A1 (en) | 2019-10-08 | 2022-11-10 | Nanolayr Limited | Nanofibre matrix made of natural polymers with natural functional ingredients for cosmetic products |
| RU2715231C1 (ru) * | 2019-10-14 | 2020-02-26 | Сергей Николаевич Таргонский | Косметическая маска-пленка для ухода за кожей лица с витаминами в липосомах |
| IT202000002833A1 (it) * | 2020-02-13 | 2021-08-13 | Bakel S R L | Procedimento di elettrofilatura |
| CN115038827A (zh) | 2020-02-13 | 2022-09-09 | 贝克尔有限公司 | 基于待静电纺丝的聚合物的天然组合物及其制备方法 |
| IT202000002827A1 (it) * | 2020-02-13 | 2021-08-13 | Bakel S R L | Composizione da elettrofilare |
| CN115066519A (zh) | 2020-02-13 | 2022-09-16 | 贝克尔有限公司 | 静电纺丝天然聚合物的方法 |
| IT202000002836A1 (it) * | 2020-02-13 | 2021-08-13 | Bakel S R L | Prodotto cosmetico |
| CZ308812B6 (cs) * | 2020-04-09 | 2021-06-02 | Contipro A.S. | Pentapeptid odvozený od kaseinu a kompozice, která jej zahrnuje a jejich topické použit |
| JP7552066B2 (ja) * | 2020-04-28 | 2024-09-18 | Ｔｏｐｐａｎホールディングス株式会社 | 生体組織貼付用フィルムおよび転写シート |
| WO2021234945A1 (ja) * | 2020-05-22 | 2021-11-25 | 北越コーポレーション株式会社 | ナノネットワーク及びその製造方法 |
| CN115843238B (zh) | 2020-06-01 | 2025-06-10 | 宝洁公司 | 改善维生素b3化合物渗透到皮肤中的方法 |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| CN111759749A (zh) * | 2020-06-30 | 2020-10-13 | 太仓淼品源材料科技有限公司 | 一种新型的玻尿酸面膜及其制备方法和使用方法 |
| CN111793854B (zh) * | 2020-08-13 | 2023-03-10 | 山东华熙海御生物医药有限公司 | 一种透明质酸纤维材料及其制备方法 |
| IT202100002891A1 (it) * | 2021-02-10 | 2022-08-10 | Saati Spa | Composizioni polimeriche per la realizzazione di membrane nanofibrose per applicazioni cosmetico-medicali e procedimento per la loro realizzazione |
| JP7818798B2 (ja) * | 2021-07-30 | 2026-02-24 | 国立大学法人福井大学 | ヒアルロン酸塩含有微細ファイバーの製造方法 |
| CZ2023120A3 (cs) * | 2023-03-28 | 2024-09-18 | Contipro A.S. | Způsob přípravy vláken a zařízení k provádění tohoto způsobu |
| CN117045847B (zh) * | 2023-09-06 | 2025-10-17 | 广州岳铧医疗科技有限公司 | 一种用于促进创面愈合的透明质酸功能性敷料及其制备方法 |
Family Cites Families (20)
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|---|---|---|---|---|
| RU2195262C2 (ru) * | 1999-08-13 | 2002-12-27 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Фармакологическое средство на основе гиалуроновой кислоты, обладающее антимикробным, ранозаживляющим и противовоспалительным действием |
| JP2004051521A (ja) | 2002-07-18 | 2004-02-19 | Katakura Chikkarin Co Ltd | 不織布に乾燥化粧品成分を含有した化粧料 |
| US20060246137A1 (en) * | 2003-07-30 | 2006-11-02 | Laurence Hermitte | Complex matrix for biomedical use |
| US7235295B2 (en) * | 2003-09-10 | 2007-06-26 | Laurencin Cato T | Polymeric nanofibers for tissue engineering and drug delivery |
| US7662332B2 (en) * | 2003-10-01 | 2010-02-16 | The Research Foundation Of State University Of New York | Electro-blowing technology for fabrication of fibrous articles and its applications of hyaluronan |
| JP2006182750A (ja) | 2004-12-27 | 2006-07-13 | Bio Meito:Kk | 凍結乾燥化粧品およびその製造方法 |
| JP2008179629A (ja) * | 2006-12-27 | 2008-08-07 | Snt Co | 化粧用シート |
| WO2009011944A2 (en) * | 2007-04-11 | 2009-01-22 | Drexel University | Fibrous mats containing chitosan nanofibers |
| CZ2007299A3 (cs) | 2007-04-24 | 2009-02-04 | Cpn Spol. S R. O. | Príprava nanovláken z polysacharidu a jejich smesí s polyvinylalkoholem |
| US20100018641A1 (en) | 2007-06-08 | 2010-01-28 | Kimberly-Clark Worldwide, Inc. | Methods of Applying Skin Wellness Agents to a Nonwoven Web Through Electrospinning Nanofibers |
| JP2009041117A (ja) | 2007-08-06 | 2009-02-26 | Nisshinbo Ind Inc | 多糖類ナノファイバー |
| JP5600005B2 (ja) * | 2007-09-05 | 2014-10-01 | 太陽化学株式会社 | 水溶性電界紡糸シート |
| KR100910241B1 (ko) | 2007-10-02 | 2009-07-31 | 주식회사 에이엠오 | 식물성 천연 추출물 또는 식물성 천연 정유를 함유하는나노섬유 및 이의 제조방법 |
| CZ303471B6 (cs) * | 2007-10-03 | 2012-10-03 | Contipro Biotech S.R.O. | Prípravek pro hojení ran a prevenci adheze bandáže na ránu obsahující chitosan-glukan |
| US9233080B2 (en) | 2008-03-27 | 2016-01-12 | Agigma, Inc. | Compositions and methods for the delivery of agents |
| US20110111012A1 (en) * | 2009-11-12 | 2011-05-12 | Hemcon Medical Technologies, Inc. | Nanomaterial wound dressing assembly |
| KR20110110482A (ko) | 2010-04-01 | 2011-10-07 | 중앙대학교 산학협력단 | 비타민이 함유된 히알우론산 나노섬유 |
| JP2013049927A (ja) * | 2011-08-30 | 2013-03-14 | Shinshu Univ | 生体適合性を有するナノ繊維及びその製造方法並びに創傷被覆材 |
| JP5871594B2 (ja) * | 2011-12-07 | 2016-03-01 | シンワ株式会社 | 化粧用シート |
| KR101454421B1 (ko) * | 2012-10-25 | 2014-11-03 | 주식회사 아모그린텍 | 자가 용융형 나노섬유로 구성된 미용시트 및 그 제조방법 |
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| CZ2013820A3 (cs) | 2015-05-06 |
| EP3060195B1 (en) | 2018-09-26 |
| WO2015058734A1 (en) | 2015-04-30 |
| EP3060195A1 (en) | 2016-08-31 |
| DK3060195T3 (en) | 2019-01-14 |
| PL3060195T3 (pl) | 2019-03-29 |
| CZ308492B6 (cs) | 2020-09-23 |
| JP6783654B2 (ja) | 2020-11-11 |
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