ES2690319T3 - Hemólisis diferencial de una muestra de sangre completa - Google Patents

Hemólisis diferencial de una muestra de sangre completa Download PDF

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Publication number
ES2690319T3
ES2690319T3 ES07725792.1T ES07725792T ES2690319T3 ES 2690319 T3 ES2690319 T3 ES 2690319T3 ES 07725792 T ES07725792 T ES 07725792T ES 2690319 T3 ES2690319 T3 ES 2690319T3
Authority
ES
Spain
Prior art keywords
sample
analyte
whole blood
red blood
hemolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07725792.1T
Other languages
English (en)
Spanish (es)
Inventor
Uwe Kobold
Thomas Duelffer
Rupert Herrmann
Herbert Von Der Eltz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2690319T3 publication Critical patent/ES2690319T3/es
Active legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/603—Construction of the column end pieces retaining the stationary phase, e.g. Frits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
ES07725792.1T 2006-06-06 2007-06-04 Hemólisis diferencial de una muestra de sangre completa Active ES2690319T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06011604 2006-06-06
EP06011604 2006-06-06
PCT/EP2007/004923 WO2007140961A1 (en) 2006-06-06 2007-06-04 Differential hemolysis of a whole blood sample

Publications (1)

Publication Number Publication Date
ES2690319T3 true ES2690319T3 (es) 2018-11-20

Family

ID=37081679

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07725792.1T Active ES2690319T3 (es) 2006-06-06 2007-06-04 Hemólisis diferencial de una muestra de sangre completa

Country Status (7)

Country Link
US (1) US7951598B2 (https=)
EP (1) EP2032979B1 (https=)
JP (1) JP5156738B2 (https=)
CN (1) CN101467036B (https=)
CA (1) CA2649633C (https=)
ES (1) ES2690319T3 (https=)
WO (1) WO2007140961A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7952067B2 (en) * 2008-10-06 2011-05-31 Quest Diagnostics Investments Incorporated Methods for detecting vitamin C by mass spectrometry
US9371509B2 (en) * 2009-09-02 2016-06-21 Roche Diagnostics Operations, Inc. Reagents for lysis of bacterial cells
JP5249905B2 (ja) * 2009-10-29 2013-07-31 株式会社日立ハイテクノロジーズ 臨床検査システム及び臨床検査法方法
US20110217777A1 (en) * 2010-03-02 2011-09-08 Teixeira Rodrigo E Process for the Extraction of Lipids from Microalgae Using Ionic Liquids
EP2567395B1 (en) * 2010-05-07 2019-12-18 UT-Battelle, LLC System and method for extracting a sample from a surface
JP5452383B2 (ja) * 2010-06-15 2014-03-26 株式会社日立ハイテクノロジーズ 生体試料前処理方法及び装置
CN103124793B (zh) * 2010-08-11 2014-12-31 协和梅迪克斯株式会社 糖化血红蛋白的测定方法
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
US8519330B2 (en) 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
US8637813B2 (en) 2010-10-01 2014-01-28 Ut-Battelle, Llc System and method for laser assisted sample transfer to solution for chemical analysis
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012054639A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US9891149B2 (en) 2011-08-08 2018-02-13 Thermo Fisher Scientific Oy Method and apparatus for automated analysis
FI20115785A0 (fi) 2011-08-08 2011-08-08 Thermo Fisher Scientific Oy Menetelmä ja laite automaattiseen analyysiin
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
JP6694509B2 (ja) * 2015-12-18 2020-05-13 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 自動化された臨床診断システムおよび方法
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
CN107561170B (zh) * 2016-07-02 2021-07-30 山东新时代药业有限公司 一种坦西莫司中间体的分析检测方法
CN106770747A (zh) * 2016-12-09 2017-05-31 广州迈达康医药科技有限公司 一种他克莫司制剂评价方法
JP7376361B2 (ja) * 2017-03-07 2023-11-08 エフ． ホフマン－ラ ロシュ アーゲー 免疫調節マクロライドのための安定な配合物
WO2022051443A1 (en) * 2020-09-03 2022-03-10 Bio-Rad Laboratories, Inc. Preparation of nucleated rbc (nrbc) analogs for use as reference hematology controls in automated hematology analyzers
CN113325171B (zh) * 2021-08-02 2021-12-21 天津康博尔生物基因技术有限公司 检测人体红细胞叶酸含量的试剂盒、检测方法及用途
CN113776903A (zh) * 2021-08-27 2021-12-10 深圳市希莱恒医用电子有限公司 一种前处理试剂的制备方法、前处理试剂及前处理方法
WO2025119902A1 (en) * 2023-12-04 2025-06-12 F. Hoffmann-La Roche Ag Hemoglobin determination methods and systems
WO2026052704A1 (en) 2024-09-05 2026-03-12 Roche Diagnostics Gmbh Extraction of macrocyclic analytes

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2410033C2 (de) 1974-03-02 1975-09-11 Merck Patent Gmbh, 6100 Darmstadt Isolierung von in lipophilen Lösungsmitteln löslichen Inhaltstoffen wäßriger Lösungen
US4286963A (en) * 1979-11-23 1981-09-01 Coulter Electronics, Inc. Differential lymphoid-myeloid determination of leukocytes in whole blood
US4529705A (en) * 1983-06-06 1985-07-16 Coulter Electronics, Inc. Reagent for combined diluting and lysing whole blood
US4751179A (en) 1984-05-31 1988-06-14 Coulter Electronics, Inc. Method and reagents for differential determination of four populations of leukocytes in blood
CA1339952C (en) * 1984-10-29 1998-07-14 William J. Knowles Immunoassays for denatured protein analytes, particularly hb alc, and monoclonal antibodies thereto
DE3446826A1 (de) 1984-12-21 1986-06-26 Günter Horst 7927 Sontheim Röhm Backenspannfutter fuer drehmaschinen zur bearbeitung von werkstuecken unter mehreren bearbeitungsachsen
IL85532A (en) 1987-03-13 1992-03-29 Coulter Electronics Method and lytic reagent system for isolation,identification and/or analysis of leukocytes from whole blood samples
US5292663A (en) 1987-11-30 1994-03-08 Sekisui Kagaku Kogyo Kabushiki Kaisha Method of treating blood containing labile glycosylated hemoglobin A1C
JPH0774799B2 (ja) * 1988-04-28 1995-08-09 積水化学工業株式会社 血中成分の測定法
US5316951A (en) 1991-06-07 1994-05-31 Carver Jr Edward L Method for the improved determination of white blood cell subpopulations
DE4300412A1 (de) * 1993-01-09 1994-07-14 Behringwerke Ag Hydrophobe Adsorbentien und ihre Verwendung zur Absorption von Lipoproteinen
US6043032A (en) * 1993-09-22 2000-03-28 Tosoh Corporation Method of extracting nucleic acids and method of detecting specified nucleic acid sequences
US5416026A (en) * 1993-10-04 1995-05-16 I-Stat Corporation Method for detecting the change in an analyte due to hemolysis in a fluid sample
US5506103A (en) * 1993-11-16 1996-04-09 Hybridon, Inc. Method for detecting charged oligonucleotides in biological fluids
US5817518A (en) 1995-12-18 1998-10-06 Coulter International Corp. Reagent and method for differential determination of leukocytes in blood
DE69625581T2 (de) 1996-03-07 2003-09-25 Coulter International Corp., Miami Cyanidfreies Reagenz und Verfahren zur Bestimmung von Hämoglobin und Leukozytendifferenzierung
US6451609B1 (en) 1996-05-30 2002-09-17 The Cleveland Clinic Foundation Method of detecting gynecological carcinomas
US5882934A (en) 1997-01-21 1999-03-16 Coulter International Corp. Composition and method for hemoglobin and cell analysis
JPH10248828A (ja) 1997-03-10 1998-09-22 Nissho Corp 溶血管
JPH1123547A (ja) * 1997-07-09 1999-01-29 Tokuyama Sekisui Ind Corp 液体クロマトグラフ用サンプリングループ及び液体クロマトグラフ
US5935857A (en) 1997-08-01 1999-08-10 Coulter International Corp. Blood diluent
US5874310A (en) 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of nucleated red blood cells
WO1999064480A1 (en) 1998-06-12 1999-12-16 Waters Investments Limited Novel ion exchange porous resins for solid phase extraction and chromatography
JP3315657B2 (ja) * 1998-06-22 2002-08-19 積水化学工業株式会社 液体クロマトグラフィー用フィルター、液体クロマトグラフィー用カラム及びヘモグロビン類の測定方法
WO1999067647A1 (en) 1998-06-24 1999-12-29 Chen & Chen, Llc Multi-layer testing column
JP3429709B2 (ja) * 1998-08-07 2003-07-22 積水化学工業株式会社 安定型ヘモグロビンＡ１ｃの測定方法
EP1103812B1 (en) * 1998-08-07 2015-11-18 Sekisui Chemical Co., Ltd. Method for determining hemoglobins
JP4391733B2 (ja) * 1998-08-07 2009-12-24 積水化学工業株式会社 ヘモグロビン類の測定方法
JP3429679B2 (ja) * 1998-08-07 2003-07-22 積水化学工業株式会社 安定型ヘモグロビンＡ１ｃの測定方法
DE19937187A1 (de) 1999-08-06 2001-03-01 Qiagen Gmbh Automatisierte Proteinreinigung im Multiwellformat durch Vakuumfiltration
EP1404875A1 (en) * 2001-06-08 2004-04-07 ChemoMetec A/S A method and a system for counting cells from a plurality of species
JP2003207497A (ja) * 2002-01-10 2003-07-25 Sekisui Chem Co Ltd 溶離液と溶血試薬及びヘモグロビン類の測定方法
US6723236B2 (en) 2002-03-19 2004-04-20 Waters Investments Limited Device for solid phase extraction and method for purifying samples prior to analysis

Also Published As

Publication number Publication date
CA2649633C (en) 2012-11-27
EP2032979B1 (en) 2018-07-18
EP2032979A1 (en) 2009-03-11
WO2007140961A1 (en) 2007-12-13
US7951598B2 (en) 2011-05-31
CN101467036A (zh) 2009-06-24
JP5156738B2 (ja) 2013-03-06
US20090253210A1 (en) 2009-10-08
CA2649633A1 (en) 2007-12-13
HK1134135A1 (en) 2010-04-16
JP2009540274A (ja) 2009-11-19
CN101467036B (zh) 2013-06-19
WO2007140961A8 (en) 2008-11-06

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