CA2649633C - Differential hemolysis of a whole blood sample - Google Patents

Differential hemolysis of a whole blood sample Download PDF

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Publication number
CA2649633C
CA2649633C CA2649633A CA2649633A CA2649633C CA 2649633 C CA2649633 C CA 2649633C CA 2649633 A CA2649633 A CA 2649633A CA 2649633 A CA2649633 A CA 2649633A CA 2649633 C CA2649633 C CA 2649633C
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CA
Canada
Prior art keywords
sample
analyte
whole blood
red blood
hemolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2649633A
Other languages
English (en)
French (fr)
Other versions
CA2649633A1 (en
Inventor
Uwe Kobold
Thomas Duelffer
Rupert Herrmann
Herbert Von Der Eltz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2649633A1 publication Critical patent/CA2649633A1/en
Application granted granted Critical
Publication of CA2649633C publication Critical patent/CA2649633C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/603—Construction of the column end pieces retaining the stationary phase, e.g. Frits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
CA2649633A 2006-06-06 2007-06-04 Differential hemolysis of a whole blood sample Active CA2649633C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06011604 2006-06-06
EP06011604.3 2006-06-06
PCT/EP2007/004923 WO2007140961A1 (en) 2006-06-06 2007-06-04 Differential hemolysis of a whole blood sample

Publications (2)

Publication Number Publication Date
CA2649633A1 CA2649633A1 (en) 2007-12-13
CA2649633C true CA2649633C (en) 2012-11-27

Family

ID=37081679

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2649633A Active CA2649633C (en) 2006-06-06 2007-06-04 Differential hemolysis of a whole blood sample

Country Status (7)

Country Link
US (1) US7951598B2 (https=)
EP (1) EP2032979B1 (https=)
JP (1) JP5156738B2 (https=)
CN (1) CN101467036B (https=)
CA (1) CA2649633C (https=)
ES (1) ES2690319T3 (https=)
WO (1) WO2007140961A1 (https=)

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US20110217777A1 (en) * 2010-03-02 2011-09-08 Teixeira Rodrigo E Process for the Extraction of Lipids from Microalgae Using Ionic Liquids
EP2567395B1 (en) * 2010-05-07 2019-12-18 UT-Battelle, LLC System and method for extracting a sample from a surface
JP5452383B2 (ja) * 2010-06-15 2014-03-26 株式会社日立ハイテクノロジーズ 生体試料前処理方法及び装置
CN103124793B (zh) * 2010-08-11 2014-12-31 协和梅迪克斯株式会社 糖化血红蛋白的测定方法
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
US8519330B2 (en) 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
US8637813B2 (en) 2010-10-01 2014-01-28 Ut-Battelle, Llc System and method for laser assisted sample transfer to solution for chemical analysis
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012054639A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US9891149B2 (en) 2011-08-08 2018-02-13 Thermo Fisher Scientific Oy Method and apparatus for automated analysis
FI20115785A0 (fi) 2011-08-08 2011-08-08 Thermo Fisher Scientific Oy Menetelmä ja laite automaattiseen analyysiin
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
JP6694509B2 (ja) * 2015-12-18 2020-05-13 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 自動化された臨床診断システムおよび方法
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
CN107561170B (zh) * 2016-07-02 2021-07-30 山东新时代药业有限公司 一种坦西莫司中间体的分析检测方法
CN106770747A (zh) * 2016-12-09 2017-05-31 广州迈达康医药科技有限公司 一种他克莫司制剂评价方法
JP7376361B2 (ja) * 2017-03-07 2023-11-08 エフ． ホフマン－ラ ロシュ アーゲー 免疫調節マクロライドのための安定な配合物
WO2022051443A1 (en) * 2020-09-03 2022-03-10 Bio-Rad Laboratories, Inc. Preparation of nucleated rbc (nrbc) analogs for use as reference hematology controls in automated hematology analyzers
CN113325171B (zh) * 2021-08-02 2021-12-21 天津康博尔生物基因技术有限公司 检测人体红细胞叶酸含量的试剂盒、检测方法及用途
CN113776903A (zh) * 2021-08-27 2021-12-10 深圳市希莱恒医用电子有限公司 一种前处理试剂的制备方法、前处理试剂及前处理方法
WO2025119902A1 (en) * 2023-12-04 2025-06-12 F. Hoffmann-La Roche Ag Hemoglobin determination methods and systems
WO2026052704A1 (en) 2024-09-05 2026-03-12 Roche Diagnostics Gmbh Extraction of macrocyclic analytes

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Also Published As

Publication number Publication date
EP2032979B1 (en) 2018-07-18
EP2032979A1 (en) 2009-03-11
WO2007140961A1 (en) 2007-12-13
US7951598B2 (en) 2011-05-31
CN101467036A (zh) 2009-06-24
JP5156738B2 (ja) 2013-03-06
US20090253210A1 (en) 2009-10-08
CA2649633A1 (en) 2007-12-13
HK1134135A1 (en) 2010-04-16
JP2009540274A (ja) 2009-11-19
CN101467036B (zh) 2013-06-19
ES2690319T3 (es) 2018-11-20
WO2007140961A8 (en) 2008-11-06

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