ES2688621T3 - Métodos para seleccionar polipéptidos resistentes a proteasa - Google Patents
Métodos para seleccionar polipéptidos resistentes a proteasa Download PDFInfo
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- ES2688621T3 ES2688621T3 ES09764259.9T ES09764259T ES2688621T3 ES 2688621 T3 ES2688621 T3 ES 2688621T3 ES 09764259 T ES09764259 T ES 09764259T ES 2688621 T3 ES2688621 T3 ES 2688621T3
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
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- C—CHEMISTRY; METALLURGY
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- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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| PCT/EP2009/066395 WO2010063818A2 (en) | 2008-12-05 | 2009-12-04 | Methods for selecting protease resistant polypeptides |
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| US8685895B2 (en) * | 2008-12-05 | 2014-04-01 | Carolyn Enever | Methods for selecting protease resistant polypeptides |
| US9012609B2 (en) | 2010-08-13 | 2015-04-21 | Glaxosmithkline Intellectual Property Development Limited | Anti-serum albumin binding variants |
| KR20130055663A (ko) * | 2010-08-20 | 2013-05-28 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 개선된 항-혈청 알부민 결합 변이체 |
| EP2866029B1 (en) * | 2012-06-22 | 2017-05-03 | Olympus Corporation | Method for preparing sample containing pancreatic juice component, and kit for storing biological sample containing pancreatic juice component at room temperature |
| AU2014290229A1 (en) * | 2013-07-15 | 2016-02-18 | North Carolina State University | Protease-resistant peptide ligands |
| JP6422977B2 (ja) * | 2013-08-30 | 2018-11-14 | エイプリルバイオ カンパニー リミテッド | 抗血清アルブミンｆａｂエフェクター部分融合コンストラクト、およびその製造方法 |
| WO2016191659A1 (en) * | 2015-05-28 | 2016-12-01 | Bio-Rad Laboratories, Inc. | Affinity ligands and methods relating thereto |
| TWI726889B (zh) * | 2015-06-10 | 2021-05-11 | 英商梅迪繆思有限公司 | 蛋白酶抗性之脂化肽 |
| JP6766253B2 (ja) * | 2017-03-28 | 2020-10-07 | 森永乳業株式会社 | 新規ビフィドバクテリウム属細菌 |
| KR20210143766A (ko) * | 2019-02-26 | 2021-11-29 | 트위스트 바이오사이언스 코포레이션 | Glp1 수용체에 대한 변이체 핵산 라이브러리 |
| US11584781B2 (en) * | 2019-12-30 | 2023-02-21 | Eligo Bioscience | Chimeric receptor binding proteins resistant to proteolytic degradation |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| US12391762B2 (en) | 2020-08-26 | 2025-08-19 | Twist Bioscience Corporation | Methods and compositions relating to GLP1R variants |
| US12122817B2 (en) * | 2020-09-22 | 2024-10-22 | Serpentide Inc. | Long-lasting GLP1 analogue drug for type-2 diabetes |
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| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| WO1989007142A1 (en) | 1988-02-05 | 1989-08-10 | Morrison Sherie L | Domain-modified constant region antibodies |
| EP1997891A1 (en) | 1988-09-02 | 2008-12-03 | Dyax Corporation | Generation and selection of recombinant varied binding proteins |
| ATE92107T1 (de) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| DE69132531T2 (de) | 1990-12-06 | 2001-09-13 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Verbindungen und ihre Verwendung in einer binären Synthesestrategie |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
| US5702892A (en) | 1995-05-09 | 1997-12-30 | The United States Of America As Represented By The Department Of Health And Human Services | Phage-display of immunoglobulin heavy chain libraries |
| CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| DK1801214T3 (da) | 1997-07-07 | 2011-01-24 | Medical Res Council | In vitro sorteringsfremgangsmåde |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| ATE380865T1 (de) | 1998-05-13 | 2007-12-15 | Domantis Ltd | Phagen-display-selektionssystem für korrekt gefaltete proteine |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| JP2003523742A (ja) | 2000-02-03 | 2003-08-12 | ドマンティス リミテッド | コンビナトリアルタンパク質ドメイン |
| DK1355942T3 (da) | 2000-12-07 | 2008-11-17 | Lilly Co Eli | GLP-1-fusionsproteiner |
| WO2002095076A2 (en) * | 2001-05-23 | 2002-11-28 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Modified polypeptides having protease-resistance and/or protease-sensitivity |
| DK1412384T3 (da) | 2001-06-28 | 2008-04-28 | Novo Nordisk As | Stabil formulering af modificeret GLP-1 |
| WO2003076567A2 (en) | 2002-03-05 | 2003-09-18 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| EP3299393A1 (en) | 2002-11-08 | 2018-03-28 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| TW200526254A (en) | 2003-09-19 | 2005-08-16 | Novo Nordisk As | Novel GLP-1 derivatives |
| PT1737962E (pt) | 2004-03-24 | 2010-12-03 | Domantis Ltd | Sequência líder universal gas1 |
| CA2589800A1 (en) * | 2004-12-02 | 2006-06-08 | Domantis Limited | Bispecific domain antibodies targeting serum albumin and glp-1 or pyy |
| MX2009003400A (es) * | 2006-10-03 | 2009-04-28 | Cadila Healthcare Ltd | Compuestos antidiabeticos. |
| GB0724331D0 (en) * | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
| EP2259802A1 (en) * | 2008-03-31 | 2010-12-15 | Glaxo Group Limited | Drug fusions and conjugates |
| US8685895B2 (en) * | 2008-12-05 | 2014-04-01 | Carolyn Enever | Methods for selecting protease resistant polypeptides |
| EA027866B1 (ru) * | 2009-02-19 | 2017-09-29 | Глэксо Груп Лимитед | Улучшенные связывающие сывороточный альбумин варианты |
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2009
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2017
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| CA2745448A1 (en) | 2010-06-10 |
| CN102307897B (zh) | 2016-01-20 |
| JP2012510803A (ja) | 2012-05-17 |
| ZA201103575B (en) | 2012-01-25 |
| US20110229458A1 (en) | 2011-09-22 |
| EP2364326A2 (en) | 2011-09-14 |
| SG194383A1 (en) | 2013-11-29 |
| US20140187750A1 (en) | 2014-07-03 |
| IL212923A0 (en) | 2011-07-31 |
| AU2009324037B2 (en) | 2015-07-30 |
| KR101740066B1 (ko) | 2017-05-25 |
| EP2364326B1 (en) | 2018-07-04 |
| US8685895B2 (en) | 2014-04-01 |
| US20180088128A1 (en) | 2018-03-29 |
| BRPI0922772A2 (en) | 2018-11-06 |
| CA2745448C (en) | 2018-09-18 |
| CN102307897A (zh) | 2012-01-04 |
| WO2010063818A3 (en) | 2010-08-12 |
| EA026508B1 (ru) | 2017-04-28 |
| WO2010063818A2 (en) | 2010-06-10 |
| US10466252B2 (en) | 2019-11-05 |
| MX2011005874A (es) | 2011-06-27 |
| AU2009324037A1 (en) | 2010-06-10 |
| JP2015231380A (ja) | 2015-12-24 |
| EA201170762A1 (ru) | 2011-12-30 |
| BRPI0922772B1 (pt) | 2021-09-08 |
| KR20110102397A (ko) | 2011-09-16 |
| JP5840498B2 (ja) | 2016-01-06 |
| US10302655B2 (en) | 2019-05-28 |
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